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SYNERGISTIC POTENTIATING ANTI-ANXIETY ACTIVITIES OF WITHANIA AND ALPRAZOLAM BY LICORICE

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Alprazolam is the most commonly used allopathic remedy for the management of anxiety. Several drugs like Withania, Valerian & Centella are the leading herbs for the management of anxiety. Magnesium hydroxide when given alone shows laxative property at all does but if it is given along with Licorice it enhances CNS activity of magnesium salt and produces hypnosis instead of laxation. Hence in the present study attempts have been made to screen possible synergistic potentiating anti-anxiety activity of Withania and Alprazolam with Licorice in elevated plus maze and dark light exploration model. In elevated plus maze model time spent in open arm and number of cross entries were increased significantly when Withania extract or Alprazolam were given along with Licorice. To conclude, if Withania or Alprazolam is given in combination with Licorice, there is enhancement of their anti-anxiety activities in mice. The synergism in the anti-anxiety activity may be due to differences in their mechanism of action or there may be increased BBB permeability of Withania and Alprazolam by Licorice because of its triterpenoid nature or may be due to inhibition of certain enzymes responsible for metabolism of Withania and Alprazolam.
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PDF icon arastrmx_160852_2_pp_264-267.pdf
  • 3
264-267
  • English

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