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FORMULATION AND EVALUATION OF BILAYER TABLET OF METOPROLOL SUCCINATE AS A CONTROLLED RELEASE AND AMLODIPINE AS A IMMEDIATE RELEASE

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
The objective of present work is to develop double layer tablet of Amlodipine as immediate and Metoprolol succinate as controlled release tablet by using HPMC as a release controlling agent. Medium and high viscosity grade used to prepare Matrix tablet. The tablets prepared by wet granulation method, well subjected to physical characterization and invitro drug release studies. The invitro drug release was carried out using USP apparatus at 50rpm in 500ml of Phosphate buffer medium (pH 6.2). The drug release rate was strongly influenced by the type of polymers and the concentration of polymer. The drug release of HPMC, Ethyl cellulose and drug release was inversely correlated. To analyze the release mechanism, Kosmeyer and Pepaas equation, Higuchi, first order model were used.
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  • 4
338-341
  • English

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