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COMPARATIVE STUDY OF MICROEMULSION BASED GEL: HYDROGEL AND ORGANOGEL

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
The objective of the present investigation was to develop and evaluate microemulsion based gel for the topical delivery. Clobetasol propionate (CP) was taken as model drug for the study. The optimized microemulsion was incorporated in gelling agent hydrogel (carbopol 934 P) and organogel (alkatrene granules). Both the gels were evaluated for their potential to gel the microemulsion by varying their concentration without affecting its structure. The gels were compared by performing evaluation parameters such as rheological parameters, spreadability, in vitro and ex vivo permeation study. Optimized microemulsion based gel of alkatrene granules was found to exhibit significant as compared to Carbopol 934 P gel. The in vitro and ex vivo permeation results showed higher permeation and retention of alkatrene gel. Thus the present study indicates that microemulsion based alkatrene gel can be a promising vehicle for the topical delivery of drugs based on the compatibility of microemulsion system with gel.
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  • 1
384-388
  • English

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