Buradasınız

Anasayfa » Content

DEVELOPMENT OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF CEFIXIME AND LINEZOLID IN TABLET DOSAGE FORM

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2013

Key Words:

Author Name
Abstract (2. Language): 
A simple, accurate, precise and sensitive UV spectrophotometric method is developed for the simultaneous estimation of Cefixime and Linezolid in tablet dosage form. The method is based on the First order derivative method. In first order derivative method, the quantification was achieved by 247.6 nm (zero crossing point of linezolid) and 236.6 nm (zero crossing point of cefixime) over the concentration range of 2-30 μg/ml respectively for estimation of cefixime and linezolid in tablet dosage form. The correlation coefficient of cefixime and linezolid were found to be 0.9992 and 0.9995 respectively. The method was validated for linearity, accuracy and precision as per ICH guidelines and hence can be used for the quantitative analysis of commercially available dosage form.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastrmx_160852_3_pp_366-369.pdf
  • 1
366-369
  • English

REFERENCES

References: 

1. United States Pharmacopoeia-30 and National
Formulary-25, Vol. 2, The United States
Pharmacopoeia Convention Inc., USA, 2007, pp 680.
2. Indian Pharmacopoeia. Government of India,
Ministry of Health and Family Welfare; The Indian
Pharmacopoeia Commission, Ghaziabad, 2010, Vol-
1, 2, pp. 1012-1013, 1580-1592.
3. J. Maryadele. Merk index, An Encyclopaedia of
Chemicals, Drugs, and Biologicals. Merck Research
Laboratories, Division of MERCK & CO INC.,
Whitehouse Station, NJ, USA, 2006, pp. 315, 954.
4. S. C. Sweetman. Martindale: The complete drug
reference. London pharmaceutical press, London,
2002, pp. 172-3, 226-3.
5. M. V. Attimarad, B. E. Dhubiab, I. A. Alhaider and A.
B. Nair. Simultaneous determination of moxifloxacin
and cefixime by first and ratio first derivative
ultraviolet spectrophotometry, Chemistry Central
Journal. 6(1): 105 (2012).
6. V. Shah and H. Raj. Development and validation of
derivative spectroscopic method for simultaneous
estimation of cefixime trihydrate and azithromycin
dihydrate in combined dosage form, Int. J. Pharm.
Sci. Res. 3(6): 1753-1760 (2012).
7. P. B. Shah and K. Pundarikakshudu.
Spectrophotometric, difference spectroscopic and
high-performance liquid chromatographic methods
for the determination of cefixime in pharmaceutical
formulations, Journal of AOAC international 89(4):
987-94 (2006).
8. A. Khan, Z. Iqbal, M. I. Khan, K. Javed, A. Khan, L.
Ahmad, Y. Shah and F. Nasir. Simultaneous
determination of cefdinir and cefixime in human
plasma by RP-HPLC/UV detection method: Method
development, optimization, validation, and its
Dharti et al., ARPB, 2013; Vol 3 (I) ISSN 2250-0774
(RESEARCH ARTICLE)
369 | P a g e w w w . a r p b . i n f o
application to a pharmacokinetic study, Journal of
Chromatography B 879: 2423– 2429 (2011).
9. P. Prashanthi, A. Mateti, P. Vanitha, M. K.
Thimmaraju and N. Raghunandan. Development
and validation of UV spectrophotometric method
for the Estimation of Linezolid in bulk and
pharmaceutical formulation, International Journal
of Pharmacy and Pharmaceutical Science Research
2(3): 57-60 (2012).
10. K. J. Prasanti and B .S. Sundar. A validated RP-HPLC
method for the determination of linezolid in
pharmaceutical dosage forms, International Journal
of Pharma and Bio Sciences 3(3): 44–51 (2012).
11. D. A. Skoog and J. J. Leqary. Principle of
Instrumental Analysis, Thomson Asia Pvt. Ltd;
Singapore, 2007, pp. 13-15, 418-23.
12. G. H. Jeffery, J. Bassett, J. Mendham and R. C. Denney.
Vogel’s Textbook of Quantitative Chemical Analysis,
Adison Wesley Longman Ltd., 1996, pp. 216-20.
13. A. G. Davidson, A. H. Beckett and J. B. Stenlake.
Practical Pharmaceutical Chemistry, New Delhi, CBS
Publishers, 2007, part-2, pp. 275-300.
14. D. A. Skoog, D. M. West, F. J. Holler and S. R. Crouch.
Fundamentals of Analytical Chemistry, Thomson
Asia Pvt. Ltd., 2004, pp. 973-74.
15. ICH Harmonised Tripartite Guideline, “Q2 (R1):
Validation of Analytical Procedures: Text and
Methodology”, 2005. Available from
URLhttp://www.ich.org/fileadmin/Public_Web_Site
/ICH_Products/Guidelines/Quality/Q2_R1/Step4/Q
2_R1 Guideline.pdf

Thank you for copying data from http://www.arastirmax.com