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ACORUS CALAMUS LINN.RHIZOMES EXTRACT FOR ANTIDEPRESSANT ACTIVITY IN MICE MODEL

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Abstract (2. Language): 
The aim of the present study was to evaluate the antidepressant activity of aqueous-ethanolic extract of Acorus Calamus, by forced swimming test (FST) and tail suspension test (TST). Acorus Calamus rhizomes extract (ACE) in doses 75mg/kg and 150 mg/kg was administered once daily for 15 days to young male Swiss albino mice to study the immobility periods of control and treated mice. The antidepressant effect of extract was compared with standard drug Lofepramine (15 mg/kg) administered for 15 days. The possible mechanism of action was explored by coadministration Doxazosin (selective α1-adrenergic blocking agents) with the extract for studying the plasma corticosterone levels. Pretreatment with ACE (75mg/kg and 150 mg/kg orally, for 15 days) significantly reduced the immobility time in both FST and TST, indicating antidepressant activity. The extract did not show significant effect on locomotor activity in mice. Doxazosin significantly attenuated the extract induced antidepressant effect. The doses of ACE significantly decreased corticosteroid levels, a measure for evaluating antidepressant activity as compared to control group. The results indicated the antidepressant effect of ACE normalizing the over-activity of hypothalamicpituitary- arenal (HPA) axis system and through interaction with adrenergic and dopaminergic systems.
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