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DEVELOPMENT OF LIPID BASED FORMULATION OF A POORLY WATER SOLUBLE DRUG

Journal Name:

  • Advance Research in Pharmaceuticals and Biologicals

Publication Year:

  • 2013

Key Words:

Author NameUniversity of Author
Abstract (2. Language): 
The present work was aimed to formulate a self emulsifying drug delivery system of lornoxicam and evaluating its in-vitro potential. The solubility of lornoxicam was determined in different oils, surfactants and cosurfactants. Pseudo ternary phase diagrams were used to evaluate the micro emulsification existence area, and the release rate of the drug was investigated using an in-vitro dissolution test. Formulations were prepared in by simple mixing at 40°C. The formulations were evaluated for parameters like macroscopic evaluation, visual assessment, self emulsification, transmittance test, droplet size, zeta potential and particle size distribution. From the solubility study, comparatively better solubility was seen in Triacetin (oil), Tween 80 (surfactant) and Capryol micro express (co-surfactant). Droplet size ranged between 18 and 24 nm. Formulations were clear and almost near to 100% transmittance after dilution with water. More than 90 % of the active was released in 20 min. as compared to pure drug.
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