TREATING RHEUMATOID ARTHRITIS WITH MEDICINAL HERBS - AN UP-TO-DATE COMPILATION OF HERBAL DRUGS USED FOR TREATING THE DISEASE

1. Development of the guideline, Rheumatoid Arthritis
National clinical guideline for management and
treatment in adults Published by Royal College of
physician pp. 3 (2009).
2. B. Singh, V. B. Pandey, V. K. Joshi, S. S. Gambhir. Antiinflammatory
studies on Polygonum glabrum,
Journal of Ethnopharmacology 19(3): 255–267
(1987).
Ghulam et al., ARPB, 2014; Vol 4 (II) ISSN 2250-0774
(REVIEW ARTICLE)
682 | P a g e w w w . a r p b . i n f o
3. S. Singh, R. Sharma, G. Singh, A. Koul, A. Khajuria, V.
K. Gupta, P. Koul. Anti-inflammatory and antiarthritic
activity of the rhizome extract of
Polygonum viviparum L. Peer Reviewed Journal on
Complementary Medicine and Drug Discovery 1(4):
225-232 (2011).
4. I. V. Kumar, B. N. Paul, R. Asthana, A. Saxena, S.
Mehrotra, G. Rajan. Swertia chirayita mediated
modulation of interleukin-1beta, interleukin-6,
interleukin-10, interferon-gamma, and tumor
necrosis factor-alpha in arthritic mice,
Immunopharmacol Immunotoxicol 25(4): 573-83
(Nov 2003).
5. J. N. Sharma, K. C. Srivastava, E. K. Gan. Suppressive
effects of eugenol and ginger oil on arthritic rats,
Pharmacology 49(5): 314-8 (Nov 1994).
6. S. Deodhar, R. Sethi, R. Srimal. Preliminary study on
antirheumatic activity of curcumin, Indian J. Med.
Res. 71: 632–634 (1980).
7. H. Hossein. H. Younesi. Antinociceptive and antiinflammatory
effects of Crocus sativus L. stigma
and petal extracts in mice, BMC Pharmacology 2: 7
(2002).
8. B. N. Paul, A. K. Saxena. Depletion of TNF-α in mice
by Nyctanthes arbortristis , J. Ethnopharmacol.
56: 153 (1997).
9. V. Deshpande, V. M. Jadhav, V. J. Kadam. In-vitro
anti-arthritic activity of Abutilon indicum (Linn.)
sweet, Journal of Pharmacy Research: 2 (4), 644-
645 (2009).
10. P. M. Mazumder, A. Mondal, D. Sasmal, S. Arulmozhi,
P. Rathinavelusamy. Evaluation of antiarthritic and
immunomodulatory activity of Barleria lupulina,
Asian Pacific Journal of Tropical Biomedicine
S1400-S1406 (December 2012).
11. P. Jaijesh, K. K. Srinivasan, A. Kumar, S. Govindan, C.
A. Mohammed, R. S. Kumar, S. N. Narayanan, P. A.
Maloor. Anti-Arthritic activity of the plant
Tinospora cordifolia willd. Journal of Herbal
Medicine and Toxicology 5 (1), 11-16 (2011).
12. P. H. Trivedi, N. L. Pathak, G. Mahendra, K. Gavaniya,
A. Patel, D. H. Trivedi, N. M. Panchal. Aegle
marmelos suppresses inflammation and cartilage
destruction in collagen-induced arthritic rat,
International Journal of Pharmaceutical Research &
Development 3(4): 38 – 45.
13. G. R. Patel, N. L. Pathak, D. J. Rathod, D. L. Patel, R. U.
Thaker. Methanolic fruits extract of randia
dumetorum suppresses inflammation and cartilage
Destruction in collagen-induced arthritic rat,
International Journal of Pharmaceutical Research &
Development 4(03): 192 -196 (May-2012).
14. S. Umar, M. Asif, M. Sajad, Md. Meraj Ansari, U.
Hussain, W. Ahmad, S. A. Siddiqui, S. Ahmad and H.
A. Khan. Anti-inflammatory and antioxidant activity
of Trachyspermum ammi seeds in collagen induced
arthritis in rats, International Journal of Drug
Development & Research 4 (1): 210-219 (2012).
15. M. Duwiejua, I. J. Zeitlin, P. G. Waterman, A. I. Gray.
Anti-inflammatory Activity of Polygonum
bistorta, Guaiacum officinale and Hamamelis
virginiana in Rats, Journal of Pharmacy and
Pharmacology 46 (4): 286–290 (April 1994).
16. J. H. Han , W. Koh, H. J. Lee, E. O. Lee, S. J. Lee, J. H.
Khil, J. T. Kim, S. J. Jeong, S. H. Kim. Analgesic and
anti-inflammatory effects of ethyl acetate fraction of
Polygonum cuspidatum in experimental animals,
Immunopharmacol Immunotoxicol 34(2): 191-5
(2012).
17. Y. Yang, T. Yu, H. J. Jang, S. E. Byeon, S. Y. Song, B. H.
Lee, M. H. Rhee, T. W. Kim, J. Lee, S. Hong, J. Y. Cho.
In vitro and in vivo anti-inflammatory activities of
Polygonum hydropiper methanol extract, J
Ethnopharmacol 31, 139 (2): 616-25 (2012).
18. T. Xuelian, S. D. Laurie, P. E. Lipsky. Effect of an
Extract of the Chinese Herbal
Remedy Tripterygium Wilfordii Hook F on
Human Immune Responsiveness, Arthritis &
Rheumatism 1274–1281: 10 (October 1991).
19. F. Yu, R. Li, R. Wang. Inhibitory effects of the
Gentiana macrophylla (Gentianaceae) extract on
rheumatoid arthritis of rats, J Ethnopharmacol
95(1): 77-81 (2004).
20. John A. O. Ojewole. Antinociceptive, antiinflammatory
and antidiabetic effects of
Bryophyllum pinnatum (Crassulaceae) leaf aqueous
extract, Journal of Ethnopharmacology 99(1): 13–
19 (May 2005).
21. G. Kweifío-Okai. Antiinflammatory activity of a
Ghanaian antiarthritic herbal preparation: II,
Journal of Ethnopharmacology 33(1–2): 129–133
(May–June 1991).
22. John A. O. Ojewole. Evaluation of the analgesic, antiinflammatory
and anti-diabetic properties
of Sclerocarya birrea (A. Rich.) Hochst stem-bark
aqueous extract in mice and rats, Phytotherapy
Research 18(8): 601–608 (August 2004).
23. S. Ekambaram, S. S. Perumal and V. Subramanian.
Evaluation of antiarthritic activity of Strychnos
potatorum Linn seeds in Freund's adjuvant
induced arthritic rat model, BMC Complementary
and Alternative Medicine 1186/1472-6882-10-
56 (2010).
Ghulam et al., ARPB, 2014; Vol 4 (II) ISSN 2250-0774
(REVIEW ARTICLE)
683 | P a g e w w w . a r p b . i n f o
24. Su-Mei Li, Xian-Wen Yang, Yun-Heng Shen, Lin
Feng, Yue-Hu Wang, Hua-Wu, Zeng, Xiao-Hua
Liu, Jun-Mian Tian, Ya-Na Shi, Chun-Lin Long, Wei-
Dong Zhang. Chemical constituents
of Aeschynanthus bracteatus and their weak antiinflammatory
activities, Phytochemistry 69(11):
2200–2204 (August 2008).
25. R. Rajendran and E. Krishnakumar. Anti-Arthritic
Activity of Premna serratifolia Linn., Wood
against Adjuvant Induced Arthritis Avicenna, J Med
Biotechnol 2 (2): 101–106 (2010).
26. Y. Ueki, S. Miyake, Y. Tominaga, K. Eguchi. Increased
nitric oxide levels in patients with rheumatois
arthritis, J. Rheumatol 230: 230–236 (1996).
27. J. Sharma, K. Srivastava, E. Gan. Suppressive effects
of eugenol and ginger oil arthritic rats,
Pharmacology 49: 314–318 (1994).
28. A. Cohen, J. Goldman. Bromelain therapy in
rheumatoid arthritis, Pennsylvania Med J 67: 27–30
(1964).
29. R. Agarwal, V. Rangari. Anti-inflammatory and antiarthritic
activities of lupeol and 19α-H lupeol
isolated from Strobilanthus
callosus and Strobilanthus ixiocephala roots, Ind. J.
Pharm 35: 384–387 (2003).
30. X. L. Tao, S. Ying, Y. Dong. A prospective, controlled,
double-blind, cross study of Tripterigium
wilfodii Hook F in treatment of rheumatoid
arthritis, Chin. Med. J 102: 327–332 (1989).
31. D. Chamundeeswari, J. Vasantha, S. Gopalakrishnan,
E. Sukumar. Free radical scavenging activity of the
alcoholic extract of Trewia polycarpa roots in
arthritic rats, J. Ethnopharmacol 88: 51–56 (2003).
32. M. Kim, J. Yi, M. Sung, H. Kim, S. Hong, H Min.
Madimadi, Korean folk medicine, blocks TNF-α, IL-
1β, and IL-8 production by activated human
immune cells, Cytokines 25: 179–186 (2004).
33. T. Hiramitsu, T. Yasuda, H. Ito, M. Shimizu, S. Julovi,
T. Kakinuma, M. Akiyoshi, M. Yoshida, T. Nakamura.
Intercellular adhesion molecule-1 mediates the
inhibitory effects of hyaluronan on interleukin-1
{beta}-induced matrix metalloproteinase
production in rheumatoid synovial
fibroblasts viadown-regulation of NF-{kappa} B and
p38, Rheumatology (Oxford) 45: 824–832 (2006).
34. J. Sylvester, A. Liacini, W. Li, F. Dehnade, M.
Zafarullah. Tripterygium wilfordii Hook F extract
suppresses proinflammatory cytokine-induced
expression of matrix metalloproteinase genes in
articular chondrocytes by inhibiting activating
protein-1 and nuclear factor-kappa B activities, Mol.
Pharmacol 59: 1196–1205 (2001).
35. Y. Tong, X. Zhang, W. Zhao, Y. Zhang, J. Lang, Y. Shi,
W. Tan, M. Li, Y. Zhang, L. Tong, H. Lu, L. Lin, L. Ding.
Anti-angiogenic effects of Shiraiachrome A, a
compound isolated from a chinese folk medicine
used to treat rheumatoid arthritis, Eur J Pharmacol
494: 101–109 (2004).
36. F. Yu, F. Yu, R. Li, R. Wang. Inhibitory effects of
the Gentiana macrophylla extract on rheumatoid
arthritis of rats, J. Ethnopharmacol 95: 77–81
(2004).
37. R. Zhang, Z. G. Liu, C. Li, et al. Du-Zhong (Eucommia
ulmoides Oliv.) cortex extract prevent OVXinduced
osteoporosis in rats, Bone 45(3): 553–559
(2009).
38. H. Hu, B. Hang, P. Wang. Anti-inflammatory effect of
radix Angelicae sinensis, Zhongguo Zhong Yao Za
Zhi 16(11): 684-6, 704 (Nov 1991).
39. http://www.healthline.com/natstandardcontent/re
hmannia
40. http://herbalhealthforall.com/wpcontent/uploads/
2012/10/Arthritis-Pain-Relief-Herbs.pdf
41. V. Babushetty, C. M. Sultanpur. Evaluation of Anti-
Arthritis Activity of Asystasia Dalzelliana Leaves,
International Journal of Pharmaceutical & Biological
Archives 3: 377-382 (2012).
42. N. Manocha, S. K. Chandra, V. Sharma, B.
Sangameswaran, M. Saluja. Anti-rheumatic and
antioxidant activity of extract of stem bark of Ficus
bengalensis, Research Journal of Chemical Sciences
1: 2-8 (2011).
43. N. K. Mishra, S. Bstia, G. Mishra, K. A. Chowdary, S.
Patra. Anti-arthritic activity of Glycyrrhiza glabra,
Boswellia serrata and their synergistic activity in
combined formulation studied in freund’s adjuvant
induced arthritic rats, J Pharm Educ Res 2: 92-98
(2011).
44. S. Tripathy, S. P. Sahoo, D. Pradhan, S. Sahoo, D. K.
Satapathy. Evaluation of anti arthritic potential
of Hybanthus enneaspermus, African Journal of
Pharmacy and Pharmacology 3: 611-614 (2009).
45. J. Paval, S. K. Kaitheri, B. K. Potu, S. Govindan, R. S.
Kumar, S. N. Narayanan, et al. Anti-arthritic
potential of the plant Justicia gendarussa Burm F,
Clinics 64: 357-360 (2009).
46. K. J. Kore, R. V. Shete, N. V. Desai. Anti-Arthritic
activity of Hydroalcoholic extract of Lawsonia
Innermis, International Journal of Drug
Development & Research 3: 217-224 (2011).
47. P. T. Purushoth, P. Panneerselvam, R. Vijaykumar,
Clement, Atlee, W. S. Balasubramanian. Antiinflammatory,
anti arthritis and analgesic effect of
ethanolic extract of whole plant of Merremia
Ghulam et al., ARPB, 2014; Vol 4 (II) ISSN 2250-0774
(REVIEW ARTICLE)
684 | P a g e w w w . a r p b . i n f o
Emarginata Burm. F, Central European Journal of
Experimental Biology 1(3): 94-99 (2012).
48. S. R. Yende, V. D. Sannapuri, N. S. Vyawahare and U.
N. Harle. Antirheumatoid Activity of Aqueous
Extract of Piper Longum on Freunds Adjuvant-
Induced Arthritis in Rats, IJPSR 1(9): (2010).
49. S. R. Arote, P. G. Yeole. Screening of Methanolic
Extract of Pongamia Pinnata Leaves for its
Antiarthritic and Analgesic Activity, Asian Journal of
Biomedical and Pharmaceutical Sciences 1: 16-23
(2011).