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FORMULATION AND IN-VITRO CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF CISAPRIDE

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Abstract (2. Language): 
In the present work, an attempt has been made to develop a self emulsifying formulation of cisapride to increase its solubility and bioavailability. Cisapride is practically insoluble in water, sparingly soluble in methanol, and soluble in acetone and it is highly lipophilic drug. SEDDS or self-emulsifying oil formulations (SEOF) are defined as isotropic mixtures of natural or synthetic oils, solid or liquid surfactants or alternatively, one or more hydrophilic solvents and cosolvents/ surfactants. In this study we prepared 7 different formulations of cisapride with varying concentration of oil, surfactant and cosurfactant and evaluated all the formulations for various parameter. From the study it was concluded that Formulation no. 4 has good emulsification property with uniform globule size and satisfactory in- vitro drug release profile.
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