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HERBAL APPROCHES FOR EPILEPSY: A REVIEW

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Abstract (2. Language): 
The epilepsies are common and frequently devastating disorders, affecting approximately 2.5 million people in the United States alone. More than 40 distinct forms of epilepsy have been identified. Epileptic seizures often cause transient impairment of consciousness, leaving the individual at risk of bodily harm and often interfering with education and employment. Therapy is symptomatic in that available drugs do not inhibit seizures, but neither effective prophylaxis nor cure is available. Compliance with medication is a major problem because of the need for long-term therapy together with unwanted effects of many drugs. Although many treatments are available, much effort is being devoted to novel approaches. Many of these approaches centre on elucidating the genetic causes and the cellular and molecular mechanisms by which a normal brain becomes epileptic, insights that promise to provide molecular targets for both symptomatic and preventive therapies.
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REFERENCES

References: 

1. M. L. Scheuer, T. A. Pedley. The evaluation and
treatment of seizures, New Engl J Med. 8(2): 1468-
1474 (1990).
2. P. Kamboj, I. Singh, N. Mahadevan, G. Chaudhary.
Anticonvulsants from nature, Pharmacology Review
3(5): 108–117 (2009).
Raj et al., ARPB, 2014; Vol 4 (III) ISSN 2250-0774
(REVIEW ARTICLE)
750 | P a g e w w w . a r p b . i n f o
3. A. G. Gilman, T. W. Rall, A. S. Nies, P. Taylor.
Goodman and Gilman’s The Pharmacological Basis
of Therapeutics, 8th Ed., New York, Pergamon Press,
1991, 3(9): pp. 436–438.
4. R. J. Porter, B. S. Meldrum. Antiepileptic drug, In:
Katzung BG, Basic and Clinical Pharmacology, 6th
Ed. London, Prentice Hall Inc. Ltd. 1995, 4(9) pp.
361-363.
5. R. L. Carasso, S. Yehuda and R. Frommer. The
anticonvulsant and thermal effects of various
cannabinoids in rats, Int J Neuroscience 8(2): 65–69
(1978).
6. G. Sierra-Paredas. Recent advances in the
neurochemistry of epilepsy, Eur Neurol Review
3(1): 96–98 (2008).
7. Y. K. Gupta, J. Malhotra, B. George, S. K. Kulkarni.
Methods and consideration for experimental
evaluation of antiepileptic drugs, Indian J Physiol
Pharmacology 43(1): 25–43 (1999).
8. E. N. Bum, G. S. Taiwe, L. A. Nkainsa, F. C. Moto, P. F.
Seke Etet, I. R. Hiana, T. Bailabar Rouyatou, P. Seyni,
A. Rakotonirina, S. V. Rakotonirina. Validation of
anticonvulsant and sedative activity of six medicinal
plants, Epilepsy Behav. 14(3): 454–458 (2009).
9. A. Ameri, J. Gleitz, T. Peters. Inhibition of neuronal
activity in rat hippocampal slices by aconitum
alkaloids, Brain Research 738(1): 154–157 (1996).
10. A. Ameri. Inhibition of rat hippocampal excitability
by the aconitum alkaloids, 1-benzoylnapelline, but
not by napelline, Eur J Pharmacology 335(2/3):
145–152 (1997).
11. A. Ameri. Inhibition of stimulus-triggered and
spontaneous epileptiform activity in rat
hippocampal slices by aconitum alkaloid
mesaconitine, Eur J Pharmacology 342(2/3): 183–
191 (1998).
12. R. Jayaraman, T. Anitha, V. D. Joshi. Analgesic and
anticonvulsant effects of Acorus calamus roots in
mice, International Journal of Pharm Tech Research
2(1): 552–555 (2010).
13. J. F. Liao, S. Y. Huang, Y. M. Jan, L. L. Yu, C. F. Chen.
Central inhibitory effects of water extract of Acori
graminei rhizoma in mice, J Ethnopharmacology
61(3): 185–193 (1998).
14. L. Chen, W. P. Liao. Changes of amino acid content in
hippocampus of epileptic rats treated with volatile
oil of Acorus tatarinowii, Zhongguo Zhong Yao Za
Zhi, 29(7): 670–673 (2004).
15. F. F. Perazzo, J. C. Carvalho, J. E. Carvalho, V. L.
Rehder. Central properties of the essential oil and
the crude ethanol extract from aerial parts of
Artemisia annua L., Pharmacology Research 48(5):
497–502 (2003).
16. J. Guo, C. Xue, J. Duan, D. Qian, Y. Tang, Y. You.
Anticonvulsant, antidepressant-like activity of
Abelmoschus manihot ethanol extract and its
potential active components in vivo, Phytomedicine,
46(3): 82-89 (2011).
17. S. B. Vohora, S. A. Shah, P.C. Dandiya. Central
nervous system studies on an ethanol extract of
Acorus calamus rhizomes, J Ethnopharmacology
28(1): 53–62 (1990).
18. D. X. Zhou, Z. X. Bao, X. S. Wu. Anticonvulsant action
of ethanolic extract of Acorus gramineus Soland,
Chinese Journal of Modern Applied Pharmacy
31(6): 510-515 (1999).
19. M. Sankari, V. Chitra, P. Silambujanaki, D. Raju.
Anticonvulsant activity of ethanolic extract of Aegle
marmelos (Leaves) in mice, International Journal of
Pharm Tech Research 2(1): 640–643 (2010).
20. A. K. Haruna. Depressant and anticonvulsant
properties of the root decoction of Afrormosia
laxiflora (Leguminosae), Phytother Research (1):
57–59 (2000).
21. N. Balakrishnan, S. Kumar, A. Balasubramaniam, B.
Sangameswaran, M. Chaurey. Antiepileptic activity
of Alangium salvifolium leaf extracts, Herbal Tech
Industry 31(6): 20–30 (2010).
22. V. S. Kasture, S. B. Kasture, S. C. Pal. Anticonvulsant
activity of Albizzia lebbeck leaves, Indian J Exp
Biology 35(1): 78–80 (1996).
23. J. Aldarmaa, Z. Liu, J. Long, X. Mo, J. Ma, J. Liu. Anticonvulsant
effect and mechanism of Astragalus
mongholicus extract in vitro and in vivo: protection
against oxidative damage and mitochondrial
dysfunction, Neurochem Research 35(1): 33–41
(2010).
24. V. S. Kasture, C. T. Chopde, V. K. Deshmukh.
Anticonvulsive activity of Albizzia lebbeck, Hibiscus
rosa sinesis and Butea monosperma in
experimental animals, J Ethnopharmacology 71(1–
2): 65–75 (2000).
25. M. T. Buznego, H. Pérez-Saad. Acute effect of an
extract of Ambrosia paniculata (Willd.) O. E. Schultz
(mugwort) in several models of experimental
epilepsy, Epilepsy Behav. 5(6): 847–851 (1997).
26. J. Aldarmaa, Z. Liu, J. Long, X. Mo, J. Ma, J. Liu. Anticonvulsant
effect and mechanism of Ann0na
diversifolia extract in vitro and in vivo: protection
against oxidative damage and mitochondrial
dysfunction, Neurochem Research 35(1): 33–41
(2010).
Raj et al., ARPB, 2014; Vol 4 (III) ISSN 2250-0774
(REVIEW ARTICLE)
751 | P a g e w w w . a r p b . i n f o
27. I. Singh, M. Singh, T. Singh, K. V. Bijjem, A. N. Kalia.
Anticonvulsant potential of Anisomeles malabarica
leaves against experimentally induced convulsions
in rats, Int J Green Pharm. 4(3): 199–205 (2010).
28. M. E. Gonzalez-Trujano, A. Navarrete, B. Reyes, E.
Cedillo-Portugal, E. Hong. Anticonvulsant properties
and bio-guided isolation of palmitone from leaves of
Annona diversifolia, Planta Med. 67(2): 136–141
(2006).
29. M. E. Gonzalez-Trujano, E. Tapia, L. Lopez-Meraz, A.
Navarrete, A. Reyes-Ramirez, A. Martinez.
Anticonvulsant effect of Annona diversifolia Saff.
and palmitone on penicillin-induced convulsive
activity, A behavioral and EEG study in rats.
Epilepsia 47(11): 1810–1817 (2006).
30. M. E. Gonzalez-Trujano, L. López-Meraz, A. Reyes-
Ramírez, M. Aguillón, A. Martínez. Effect of repeated
administration of Annona diversifolia Saff. (Ilama)
extracts and palmitone on rat amygdala kindling,
Epilepsy Behav. 16(4): 590–595 (2009).
31. A. K. Saluja, P. D. Santani. Pharmacological screening
of an ethanol extract of defatted seeds of Annona
squamosa, Int J Pharmacognosy 32(2): 154–162
(1994).
32. D. Kaushik, A. Tripathi, R. Tripathi, M. Ganachari, S.
A. Khan. Anticonvulsant activity of Bacopa
monniera in rodents, Braz J Pharm Science 45(4):
643–649 (2009).
33. A. Krishnakumar, P. M. Abraham, J. Paul, C. S.
Paulose. Down-regulation of cerebellar 5-HT (2C)
receptors in pilocarpine-induced epilepsy in rats:
therapeutic role of Bacopa monnieri extract, J
Neurol Science 284(1–2): 124–128 (2009).
34. A. Krishnakumar, M. S. Nandhu, C. S. Paulose.
Upregulation of 5-HT2C receptors in hippocampus
of pilocarpine-induced epileptic rats: antagonism by
Bacopa monnieri, Epilepsy Behav. 16(2): 225–230
(2009).
35. R. Solomonia, N. Kuchiashvili, A. Berulava, V.
Pkhakadze, N. Trapaidze, M. Zhvania, I. Abesadze, H.
Kojima, N. Dalakishvili. Purification and
identification of components of the Aquilegia
vulgaris extract fraction exhibiting anti-epileptic
activity, J Biol Phys Chem. 4(4): 185–192 (2004).
36. S. M. M. Vasconcelos, S. R. Lima, P. M. Soares, A. M. S.
Assreuy, F. C. F. de Sousa, R. F. G. Lobato, G. S.
Vasconcelos, T. Santi-Gadelha, E. H. S. Bezerra, B. S.
Cavada, M. C. A. Patrocínio. Anticonvulsant effects of
some medicinal plants, Epilepsy Behav. 15(3): 291–
293 (2009).
37. A. S. Abdul-Ghani, S. G. El-lati, A. I. Sacaan, M.S.
Suleiman, R. M. Amin. Anticonvulsant effects of
some arab medicinal plants, Pharm Biology 25(1):
39–43 (1987).
38. N. S. Vyawahare, S. L. Bodhankar. Anticonvulsant
activity of Cedrus deodara in mice, Indian J Pharm
Science 71(2): 131–134 (2009).
39. T. C. de Lima, G. S. Morato, R. N. Takahashi.
Evaluation of the central properties of Calesia
cormendalin, Planta Med. 59(4): 326–329 (1993).
40. J. Aldarmaa, J. Liu, J. Long, O. Nyamdalai, J. Ariunaa.
Antioxidant and anticonvulsant effects of medicinal
herbs, Mongolian Academy of Sciences 1(4): 4–15
(2010).
41. A. Jalsrai, G. Grecksch, A. Becker. Evaluation of the
effects of Clitoria ternatea Bunge saponin extract on
central nervous system functions, J
Ethnopharmacology 131(3): 544–549 (2010).
42. J. Tortoriello, L. Aguilar-Santamaría. Evaluation of
the calcium-antagonist, antidiarrhoeic and central
nervous system activities of Cotyledon orbiculata, J
Ethnopharmacology 53(3): 157–163 (1996).

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