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İNSAN TÜKÜRÜĞÜNÜEKİ PEROKSİDAZ VE TİOSlYANATIN DİŞ ÇÜRÜĞÜ VE ÇÜRÜĞE NEDEN OLAN BAKTERİLERLE İLİŞKİSİ

PEROXIDASE AND THIO CYAN ATE OF HUMAN W1IOLK SALIVA IN RELATION TO DENTAL CARIES AND CAKIOGENİC BACTERIA

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Abstract (2. Language): 
Human saliva contains an antimicrohiaf system comprised of salivary peroxidazc, ıhiocyanate and hydrogen peroxidase. The oxidation of thiocyanatc by hydrogen peroksidasc calaly/.ed by salivary peroxidase, yielding the antimicrobial agent hypothiocyanitc. Several studies have suggested that the pcrotsdation reaction serves at least two important functions in the human mouth. The products of the reaction inhibit bacterial growth and metabolism and reaction prevents the accumulation by hydrogen peroxide excreted by many strain of oral streptococci . Twenty four male and twenty six women examined and analyzed the stimulated flow rate, pHt buffer capacity, pcroAİdaze and thiocyanatc and number of mutans streptococci (S.mutans) and Lactobacilli- Statistically analyses showed correlations between peroxidase and stimulated flow rate (>005) but no correlation found between peroxidase, and DMF, buffer capacity, number of S.mııtans and İactobacilli (>0.05). On the other hand, statistically analyses showed no correlaion found between thiocyanatc and DMF, stimulated flow rate, buffer capacity and laetobacil Q0.Q5).
Abstract (Original Language): 
İnsan tükürüğü hidrojen peroksid, tiosiyanat vc peroksidi içeren bir anlimikrobial sisteme sahiptir. Tükürük peroksidaz^ tiosiyanalın hidrojen peroksid tarafından bir anlimikrobial ajan olan hi potiosi yanala d ön üşmesini katalizler. Yapjlan çalışmalar peroksidaz reaksiyonunun oral kavitede en az iki büyük role sahip olduğunu desteklemektedir. Reaksiyon ürünleri bakterilerin büyümesini ve metabolizmasını inhibe eder vc oral streptokoklarının ürcltiğ hidrojen peroksidin akCimülasyunıtnu önler. Çatışmamızda 24 erkek ve 26 kadm muayene edilerek uyarılmış tükürük akış hızı, tamponlama kapasitesi, peroksidaz, tiosiyanat vc streptokok mutans (S.ımıtans), laktobasil düzeyi analiz edildi. Peroksidaz ile uyarılmış akış hızı arasında istatistiksel bir ilişki tesbit edildi (>0-05), ancak peroksidaz ile DMF, tamponlama kapasitesi, Sjmıtans ve laktobasil düzeyi arasında bir ilişki tespit edilemedi (>0.05). Aynı şekilde tiosiyanat ile DMF, S.mutans, uyanlmLŞ tükürük akjş hı/.ı, tamponlama kapasitesi vc laktobasil düzeyi arasında bir ilişki saptanamadı O0.05)
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