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NON-HODGKİN LENFOMADA RADYOTERAPİ VE KEMOTERAPİ SONUCU GÖRÜLEN MİKRODONTİ: 2 OLGU SUNUMU

MICRODONTIA ASSOCIATED WITH THE USE OF RADIOTHERAPY AND CHEMOTHERAPY OF A NON-HODGKIN LYMPHOMA: REPORT OF TWO CASES

Journal Name:

  • Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 2012

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
One of the childhood malignancies can be defined as non-Hodgkin lymphomas. These are known as the third most common malignancies in children and adolescents. Burkitt's lymphoma is a poorly differentiated rare and aggressive type of non- Hodgkin's lymphoma. Clinically, this disease occurs mostly in children. The incidence peaks between ages 3-8 years. It is well known that using chemotherapy and radiotherapy procedures could improve the survival rate of these malignant diseases. However, treatments may cause deleterious effects. Dentofacial abnormalities are known as the most common longterm side effects after the usage of chemotherapy and/or radiotherapy procedures in growing patients. These disturbances can be seen in different ways such as arrested root development, disturbances in enamel formation, discolorations, microdontia, anodontia, altered tooth eruption and mandibulary/maxillary hypoplasia. Mainly, several factors such as age, treatment time, radiation dose/ duration time of chemotherapy may effect the outcomes of these side effects. In such studies, dental disturbances have been shown in children who were treated before the ages of 5-6 years. This article reports the long-term alterations on dental development in two patients who had been treated with antineoplastic therapy at the age of 3-6 years. Chemotherapy and radiotherapy procedures were used together. Microdontia and arrested root development were detected in premolar teeth for both patients at follow up periods. These case reports indicated that children who had been exposed to the chemotherapy and/or radiotherapy procedures might have an increased risk of having developmental dental disturbances and should be carefully followed up during the developing dentition.
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Abstract (Original Language): 
Çocukluk döneminde görülen malignensilerden birisi non-Hodgkin lemfoma olarak adlandırılabilir. Bunlar çocukluk ve ergenlik döneminde 3. en sık görülen malignensilerdir. Burkitt lemfoma zor teşhis edilen, nadir ve agresif bir non-Hodgkin lemfomadır. Klinik olarak, bu hastalık en çok çocuklarda görülür. İnsidansı 3-8 yaş arasında zirve yapar. Kemoterapi ve radyoterapi işlemlerinin bu malignant hastalıklarda sağ kalım oranını yükselttiği iyi bilinmektedir. Ancak, tedaviler zararlı etkiler de yapabilmektedir. Dentofasiyal anomaliler büyüme çağındaki hastalarda kemoterapi ve/veya radyoterapi kullanımı sonrası en çok görülen yan etki olarak bilinmektedir. Bu bozukluklar kök gelişiminin durması, mine oluşumunda bozukluk, renklenmeler, mikrodonti, anodonti, diş sürmesinde bozukluk ve mandibuler/maksiler hipoplazi gibi değişik şekillerde görülebilir. Aslında hastanın yaşı, tedavi zamanı, kemoterapinin ve radyasyonun dozu/süresi gibi birkaç faktör bu yan etkilerin sonuçlarını etkileyebilir. Bu tür çalışmalarda, 5-6 yaşından önce tedavi edilen çocuklarda dental bozukluklar gösterilmiştir. Bu makale 3-6 yaş arasında antineoplastik terapiyle (kemoterapi-radyoterapi) tedavi edilen 2 hastada dental gelişimdeki uzun dönem değişiklikler bildirilmektedir. Takip periyotlarında her iki hastada premolar dişlerinde mikrodonti ve kök gelişiminde durma tespit edilmiştir. Bu vaka raporları kemoterapi ve/veya radyoterapi işlemlerine maruz kalan hastaların gelişimsel diş bozuklukları yönünden artmış bir riske sahip olduklarını ve gelişim sırasında dentisyonun dikkatlice takip edilmesine işaret etmektedir.
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  • 1
77-82
  • Turkish

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