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DOXORUBICIN VE DAUNOBİCİNİN ERİTROSİT VE LOKOSITLER ÜZERİNDEKİ SİTOTOKSİK ETKİLERİ

CYTOTOXIC EFFECTS OF DOXORUBICIN AND DAUNORUBICIN ON ERYTHROCYTES AND LEUKOCYTES

Journal Name:

  • Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

Publication Year:

  • 1996

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Cytotoxic effects of doxorubicin and uamıurübicifı on erythrocytes and leukocytes in vitro were investigated ultrastnicturaliy. A remarkable effect induced by both drugs on the shape of erythrocytes was detected. With doxorubicin, predominance of acanthocytes and in addition discocyte, echinotype, stomatocyte, spherostomatocyte, schizocyte and keratocyte shapes were seen. With daiinomycin stomatocytes were detected. With both agents, in erythrocytes sometimes plasma membrane was not observed and there electron dense material of erythrocyte was protruded out. Irregularity of plasma membranes of leukocytes was observed. There was projections from plasma membranes of these cells. Debris of cells were observed in intercellular spaces
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Abstract (Original Language): 
Doxorubicinin vç daunorubi cinin eritrosit ve lokositler üzerindeki sitatoksik etkileri ultrasütrüktfirel olarak incelendi. Her iki ajan eritrositlerin şeklinde belirgin değişiklikler oluşturdu. Doxorubicin uygulanması ile akantositler başta olmak üzere diskosit, ekinotip, sitomatosU+ sferostomatosit, şizosiı ve keratositler izlendi. Daunomicin ile stomatosıtler izlendi. Her iki ajanla eritrositlerin plazma membranları bazen izlenmiyordu ve bu alanlardan eritrositin elektron-yoğun İçeriğinin dışarıya taştığı gözlendi. Lökositîerin plazma membranında düzensizlik mevcuttu. Bu hücrelerin plazma membranlannda uzantılar izlendi.' İntersellüler alanlarda hücre artıklar gözlendi
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  • 2
51-54
  • Turkish

REFERENCES

References: 

1. Haskell CM. Drugs used in cancer chemotherapy. In: Haskell CM(ed). Cancer Treatment Philadelphia: WB Saunders, 1990: 44-102.
2. Barabas K, Sizansky JA, Faulk WP. Transferrin conjugates of adriamycin arc cytotoxic without intercalating nuclear DNA. Helv Med Acta 1992; 267(13):
9439-42.
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Ataltlrk Üniv.Dis Hek,Fak.Derg. Cilt:6 Say*:2 Sayfa: .51-54,1996
EŞREFOĞLU, SELÎMOĞLU
3. Bull BS, Breton-Gorius J, Beutler E. Morphology of erythron. In Williams WJ, Meutler E, Erslev AJ, Lichtman MA (eds). Hematology: New-York, St Louis: McGraw-Hill, 1991: 297-316,
4. Diociaiuti M, Molinari A, Catcabrini A, Atancia G. Electron energy loss spectroscopy analyses of adriamycin -plasma membrane interaction. Int J Psychophysiol. 1991; 164; 95-106.
5. Arancia G, Molinari A, Ciateri P.Calcabrini A, Silvestri Isacchi G. Differential effects of Adriamycin and daunomycin of the cell shape and pla&ma membrane ultrasiructure of human erythrocytes. Inst Phys Conf Ser No:93 Volume 3, Chapter 17 EUREM 88, York, England, 1988.
6. O'Keefe DA, Schaeffer DJ. Hematologic toxicosis associated with doxorubicin administration in cats. J Charles Tweed Int Found L992; 6(5): 276-82.
7. Oum'hamed Z, Joly P, Brpglio C, Dufer J, Desplaces A, Study of erythroid differentiation of K 562 cells resistans to adriamycin. Ann Pharm Fr. 1993; 51(5): 239-349.
8- Roobis AR, Fawhtrop DC. Mechanisms of cell injury. In: McGee JO, Isaacson, Wright (eds). Oxford Textbook of Pathology: Oxford University Press, 1992: 183.
9. Awasthi S, Sharma R. Awasthi VC, Belli JA, Frenkel EP. The relationship of doxorubicin binding to membrane lipids with drug resistance. John Hopkins Nurses Alumn Mag. 1992; 63(2): 109-16.
10. el-Mofty MM, Sakr SA, OSman SI, Daebees AY,Toulan BA. Effects of adriamycin on the morphology of the erythrocytes and blood parameters of the toad Bufo regulars. Schweiz Z Med Traumato! 1992; 2(3): 151-5.

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