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ELEKTRİKLE UYARILAN İZOLE KOBAY VE FARE SOL ATRİYUMU VE SIÇAN DİYAFRAMININ KASILMASI ÜZERİNE KALSİTONİN’İN ETKİLERİ

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Abstract (2. Language): 
Although the regulatory role of calcitonin released from the parafolicular cells of thyroid gland and its essential role in the haemoestasis of blood Ca2+ was well documented, its effects on the physiological functions of tissues except bones is not yet fully established. Therefore, the aim of this study was to explore, how calcitonin acts on the contractile activity of heart and striated muscle. Design and Results.- Experiments were carried out on the isolated electrically driven left atria of guinea-pigs and mice and phrenic nervediaphragm preparations of rats. In the electrically driven guinea-pig left atria (1 Hz, 2 msec, 2x threshold voltage), contractility was depressed by ampule calcitonin (Miacalcic) in a dosedependent manner at concentrations in range of 0.25-4 μg/ml. This effect of ampule calcitonin was weaker with respect to those produced by the solvent being in the same amount. Especially at 2 and 4μg/ml of ampule calcitonin, the contractile response was biphasic, e.g. an initial short-lived positive inotropic effect was preceding the main negative inotropic one. Theophylline (0.5 mM), atropine (2 μg/ml) and methylene blue (2 μg/ml) antagonized ampule calcitonin nonsignificantly, whereas the effect of solvent remained unaltered. Verapamil (0.5 μg/ml), however, augmented the negative inotropic effect of both ampule calcitonin and the solvent. In the phrenic nerve-diaphragm preparation, although contractions induced by direct electrical stimulation (0.1 Hz, 5 msec, 2x threshold voltage) was depressed by ampule calcitonin dosedependently in a concentration range of 1-8 μg/ ml, contractions induced by nerve stimulation (0.1 Hz, 1 msec, 2x threshold voltage) was augmented over a concentration of 4 μg/ml. Conclusion.- Depending on these findings, it was concluded that calcitonin has a stimulatory effect on the contractile function of heart and striated muscle which is masked by the solvent and that cAMP, cGMP and Ca2+ channels all appeared to involve in the cardiac effects of the test agent.
Abstract (Original Language): 
Tiroid bezi parafoliküler hücrelerinden salgılanan ve kan Ca2+ homeostazında ö- nemli rol oynayan kalsitonin’in kalb ve çizgili kas kasılması üzerine etkileri araştırılmıştır. Elektrikle uyarılan kobay solatriyumlannda (1 Hz, 2 msn, 2x eşik voltaj) ampul kalsitonin (Miacalcic) 0.25-4 μg/ml konsantrasyon aralığında kasılmayı doza-bağımlı bir şekilde deprese etmiştir. Ampul kalsitonin’in bu etkisi, eşit hacimde solventin oluşturduğu etkiden daha zayıftır. Özellikle, 2 ve 4 μg/ml konsantrasyonlarda etki bifazikleşmektedir, yani asıl negatif inotropik etkiye kısa ömürlü pozitif intropik bir etki öncülük etmektedir. Teofilin (0.5mM), atropin (2 μg/ml) ve metilen mavisi (2 μg/ml) solventin etkisini değiştirmediği halde, ampul kalsitonin’i anlamsız da olsa antagonize etmiştir. Verapamil (0.5 μg/ml) ise, hem solvent ve hem de ampul kalsitonin’in negatif inotropik etkisini artırmıştır. Frenik sinir-diyafram pre paratõnda ampul kalsitonin 1-8 μg/ml konsantrasyon aralığında direkt elektriksel uyarıya bağlı kasılmayı (0.1 Hz, 5 msn, 2x eşik voltaj) doza bağımlı olarak deprese ederken, sinirsel uyarıya bağlı kasılmada (0.1 Hz, 1 msn, 2x eşik voltaj) 4 μg/ml’den sonra artma yapmıştır. Bu bulgulara dayanarak, kalsitonin’in kasılmayı artırıcı bir etkisi olduğu, bu etkinin solvent tarafından maskelendiği ve kalpte kalsitonin’in etkisinde cAMP, cGMP ve Ca2+ kanallarının bir rolü olabileceği sonucuna varılmıştır.
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