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TİP 2 DİYABETLİ HASTALARDA C VİTAMİNİ UYGULAMASININ ERİTROSİT GLUTATYON VE HBA1C DÜZEYLERİ ÜZERİNE ETKİSİ

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2000

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Diabetes mellitus (DM) has some complications. Oxidative stress plays an important role in the creation of these complications. At the other hand vitamin C plays nonenzymatic antioxidant role in the organisms. The goal of our study was to compare glycosylated haemoglobin (HbA1c) and glutathione (GSH) levels of the 20 type 2 DM patients taking vitamin C with the 20 type 2 DM patients taking placebo. The amount of HbA1c by chromatographic elution and glutathione were measured by using capillary electrophoresis technique at the first day, first month and second month. Results.- After usage of vitamin C for one month, the values of HbA1c were decreased significantly but GSH levels were still without a significant difference. After usage of vitamin C for two months, the values of HbA1c were decreased significantly and GSH levels were increased significantly. After one and two months usage of placebo, the values of both HbA1c and GSH were still without a significant difference. Conclusion.- Comparison of the vitamin C taking group with the plasebo receiving group showed that these findings and results must be considered as positive effect of the vitamin C to the patients. This is because of the decreasing of the glycosylated haemoglobin and increasing of the glutathione levels. The glutathione levels are all found as in lower value when compared with non chromatographic method. This is because of the exact molecular prediction and measurement of the species.
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Abstract (Original Language): 
Antioksidan vitaminler insulin salgı- lanmasının regülasyonunda önemli bir role sahiptir. Doğal bir antioksidan olan GSH ve antioksidan vitaminler diyabetin komplikasyonlarından olan serbest radikal oluşumunu engelleyebilmektedir. Diyabetes mellitus glukoz homeostazisinin bozulması ile ortaya çıkan bir hastal ıktır. Tip 2 Diyabetin komplikasyonlar ından birisi HbA1c yüzdesinin artması- dır. Diğer bir komplikasyon ise serbest radikal oluşumunun artmasıdır. GSH ve C vitamini diyabetle artan oksidatif hasara karşı hücreleri koruyabilmektedirler. Çalışmamızda tip 2 diyabetli hastalarda C vitaminin HbA1c ve GSHdüzeyleri üzerine olan etkisinin incelenmesi amaç- landı. Yaşları 40-60 arasında olan 20 tip 2 diyabetli C vitamini alan, aynı sayıda ve yaşta olan ve tip 2 diyabetli plasebo kullanan kontrol grubu karşılaştırıldı. HbA1c tayini Helena HbA1c kiti ile, GSH düzeyleri kapiller elektroforez yöntemi ile yap ıldı. C vitamini kullanan Diyabetik hastalarda C vitamini kullanmadan önceki duruma göre 30. gün ve 60. gün sonunda HbA1c düzeylerinde anlamlı bir azalma ve GSH düzeylerinde anlamlı bir artma bulunmuştur. Plasebo verilen hastalarda her iki paremetrede de anlamlı bir fark görülmemiştir. Sonuç olarak C vitamini verilmesinin antioksidan etkiyi arttırdığı ve nonenzimatik glikozillenmeyi azalttığı, bu nedenle de koruyucu etkisinin olduğu kanatine varılmıştır.
FULL TEXT (PDF): 
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  • 4
211-215
  • Turkish

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