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AKUT İSKEMİK STROKTA SERUM NÖRON-SPESİFİK ENOLAZ’IN PROGNOSTİK DEĞERİ

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The aim of the study was to see whether the serum neuron specific enolase (NSE) levels, as a noninvasive technique could be utilized to determine the morbidity at early stage after acute ischemic stroke. Design.- In the present study, 40 patients with acute ischemic stroke and 20 ages and gender matched volunteer were investigated. Serum NSE levels at 48th hours, fifth days, and tenth days were analyzed and simultaneous clinical status according to Scandinavian stroke scale was examined and infarct volumes at 48th hours were measured. Results and Conclusion.- There was a statistically significant difference in serum NSE values at 48th hours and fifth days of whole patient group (22,51±7.05 ng/ml, 13,1±4,76 ng/ml, respectively) compared to those of control group (8.54±2,58 ng/ml), ( p<0.001, p<0.01, respectively). However there was no statistically significant difference between the patients and controls at 10 days (p<0.01). So, it was thought that NSE had 94% sensitivity and 80% specifity for acute ischemic stroke. There were positive correlation among NSE levels and infarct volumes, and negative correlation among NSE levels and clinical status.
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Abstract (Original Language): 
Bu çalışmanın amacı, akut iskemik strok sonrası morbiditenin erken dönemde belirlenmesinde serum Nöron Spesifik Enolaz (NSE) düzeyinin noninvazif bir yöntem olarak kulanılıp kullanılamayacağını araştırmaktır. Bu çalışmaya akut iskemik stroklu 40 hasta ve yaş ve cinsiyet özellikleri uyumlu 20 gönüllü alınmıştır. Çalışma grubunun strok sonrası 48. saat, 5. ve 10. günlerdeki serum NSE düzeyleri ile eş zamanlı Scandinavian Strok Skalası’na göre klinik durumları ve 48. saatteki infarkt volümleri belirlendi. Tüm hastaların 48. saatteki ve beşinci gündeki serum NSE değerleri ile (sırasıyla; 22,51± 7,05 ng/ml, 13,1±4,76 ng/ml) kontrol grubunun serum NSE değerleri (8,54±2,58 ng/ml) arasında istatistiksel olarak anlamlı fark bulundu (sırasıyla p<0.001, p<0.01). Onuncu gündeki serum NSE değerleri ile kontrol grubunun serum NSE değerleri arasında ise istatistiksel anlamlılık mevcut değildi (p>0.05). Serum NSE seviyeleri ile İnfarkt volümü arasında anlamlı pozitif ilişki, serum NSE değerleri ile klinik durum arasında ise anlamlı negatif ilişki gözlendi. NSE’nin akut stroklu hastalarda sensitivitesi %94 ve spesifitesi %80 olarak bulundu.
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  • 2
81-85
  • Turkish

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