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LİPOMATÖZ TÜMÖR SERİMİZİN DAĞILIMI VE YENİ TANIMLANAN LİPOMATÖZ

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Abstract (2. Language): 
Lipomatous tumors make up the largest group of the mesenchymal tumors. In the past ten years significant changes have been made on the classification of the lipomatous tumors. In this report, we aimed to evaluate the histopathological and clinical aspects of lipomatous tumors diagnosed at our department between 1988 and 1999 according to these changes. Methods.- Lipomatous tumors diagnosed at Istanbul University Cerrahpasa Faculty of Medicine between 1988 and 1999, have been classified according to Enzinger and Weiss’ classification. The cases were evaluated by age, sex, localization average diameter, largest diameter and multiplicity criteria. Results.- Out of the 843 lipomatous tumors, 799 were benign and 44 were malignant. 630 cases were classified as lipoma (75%), 83 cases as angiolipoma (10%), 52 cases as fibrolipoma (6%), 11 cases as infiltrating lipoma (1,3%), 10 cases as spindle cell lipoma (1%), 2 cases as giant lipoma (0,2%), 2 cases as angiomyolipoma (0,2%), 3 cases as lipoblastoma (0,3%), 1 case as plemorphic lipoma (0,1%), 1 case as myxolipoma (0,1%), 1 case as atypic lipoma (0,1%) and 1 case as myolipoma (0,1%). All groups showed correlation with the literature for the criteria of age, sex, localization, average diameter, largest diameter and multiplicity. Number of cases of simple lipomas with multiple location was similar with that of Enzinger’s series. The maximum diameter and infiltrative margin in spindle cell lipomas, and maximum diameter in angiolipomas differed from the current literature. Recently described entities were discussed.
Abstract (Original Language): 
Lipomatöz tümörler mezenkimal tümörlerin en yaygın grubudur. Son yıllarda lipomatöz tümörlerin sınıflamasında belirgin değişiklikler Temmuz-Eylül 2003 LİPOMATÖZ TÜMÖRLER; ÜSTÜNDAĞ VE DERVİŞOĞLU 125 olmuştur. Çalışmamızda on bir yıllık lipomatöz tümör serimizi bazı klinik ve morfolojik özellikleriyle değerlendirip, bulgularımızı diğer serilerle karşılaştırmayı ve ayırıcı tanı kriterlerini yeni literatür bilgileriyle tartışmayı amaçladık. 1988-1999 yılları arasında Cerrahpaşa Tıp Fakültesi Patoloji Anabilim Dalı’nda tanı almış lipomatöz tümörler Enzinger ve Weiss’in sınıflamasına göre sınıflandırıldı. Olgular yaş, cinsiyet, yerleşim yeri, ortalama çap, en büyük çap, multipl olma özelliklerine göre değerlendirildi. Serimizde 843 lipomatöz tümör saptandı. Bunların 799’u benign, 44’ü maligndi. Benign tümörlerde 630 olgu lipom (%75), 83 olgu angiolipom (%10), 52 olgu fibrolipom (%6), 11 olgu infiltran lipom (%1,3), 10 olgu spindle cell lipom (%1), 2 olgu dev lipom (%0,2), 2 olgu angiofibrolipom (%0,2), 2 olgu angiomyolipom (%0,2), 3 olgu lipoblastom (%0,3) 1 olgu pleomorfik lipom (%0,1), 1 olgu miksolipom (%0,01), 1 olgu atipik lipom (%0,1), 1 olgu myolipom (%0,01) olarak sınıflandırıldı. Olgularımız kendi gruplarına göre yaş, cinsiyet, yerleşim yeri, ortalama çap, maksimum çap, multipl olma özelliklerine göre diğer serilerle karşılaştırıldı. Basit lipomlarda multipl olgu sayımız Enzinger’in serisine yakın bulundu. Bu grupta en büyük çap 40 cm ile genel literatür bulgularından büyük bulundu. Spindle cell lipomlarda en büyük çap ve infiltratif sınır, angiolipomlarda en büyük çap genel literatür bulgularından farklı olarak değerlendirildi. Yeni tanımlanan lipomatöz tümörler literatür bilgileriyle sunuldu.
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REFERENCES

References: 

1. Enzinger FM, Weiss SW. Soft Tissue Tumors. Third
edition. Missouri, Mosby, 1995; 381-466.
2. Fletcher CDM. Diagnostic Histopathology of Tumors.
Second edition London, Churchill Livingstone,2000;
1478-1480.
3. John SJ. Disorders Soft Tissue. Diagnostic Surgical
Pathology. Ed. Stephen S. Sternberg. Third edition.
Philadelphia. Lippincott Williams&Wilkins, 1999; 148-
149.
4. Hunt SJ, Santa Cruz DJ, Barr RJ: Celluler angiolipoma.
Am J Surg Pathol 1990; 14: 75-81.
5. Kanik AB, Oh CH, Bhawan J. Cellular angiolipoma. Am
J Dermatopathol 1995; 17: 312-315.
6. Meis JM, Enzinger FM. Myolipoma of soft tıssue. Am J
Surg Pathol 1991; 15: 121-125.
7. Michal M. Retroperitoneal myolipoma. A tumour
mimicking retroperitoneal angiomyolipoma and
liposarcoma with myosarcomatous differentiation.
Histopathology 1994; 25: 86-88
8. Mentzel T. Lipomatous tumors of the skin and soft tissue.
New entities and concepts
Pathologe 2000; 21: 441-448. (Review)
9. Enzinger FM, Harvey DA. Spindle cell lipoma. Cancer
1975; 36: 1852-1859.
10. Domanski HA, Carlen B, Jonsson K, Mertens F,
Akerman M. Distinct cytologic features of spindle cell
lipoma. A cytologic-histologic study with clinical,
radiologic, electron microscopic, and cytogenetic
correlations.Cancer 2001; 93: 381-389.
11. Sciot K, Polito P. Lesions of 13q may occur
independently of deletion of 16q in spindle
cell/pleomorfic lipomas. Histopathology 1997; 31: 222-
225.
12. ShmookierBM, Usar MC. Pleomorfic lipoma: A benign
tumor simulating liposarcoma: A clinicopathologic
analysis of 48 cases. Cancer 1981; 47: 126-133.
13. Chen CM, Lo LJ, Wong HF. Congenital infiltrating
lipomatosis of the face: case report and literature review.
Chang Gung Med J 2002; 25: 194-200.
14. Evans HA, Donnelly LF, Johnson ND, Blebea JS, Stern
PJ. Fibrolipoma of the median nerve. MRI Clin Radiol
1997; 52: 304-307. (Abstract)
15. Milgram JW. Massive fibrolipoma of a toe. J Foot Ankle
Surg 1997; 38: 223-226. (Abstract)
16. Kershisnik W, McCarthy DJ, O’Donnell E.
Angiofibrolipoma. A histologic variant of the lipoma.J
Am Pediatr Med Assoc 1986; 76: 67-70.
17. Argenyi ZB, Piette WW, Goeken JA.Cutaneous
angiomyolipoma: A light- microscopic
immunohistochemical, and electron microscopic study.
Am J Dermatopathol 1991; 13: 497-502.
18. Buyukbabani N, Tetikyurt S, Ozturk AS. Cutaneous
angiomyolipoma: report of two cases with emphasis on
HMB-45 utilitity. J Eur Acad Dermatol Venereal 1998;
11: 151-154.
19. Barnard M, Lajoe G. Angiomyolipoma:
Immunohistochemical and ultrastructural study of 14
cases. Ultrastruct Pathol 2001; 25: 21-29.
20. Miller GG, Yanchar NL. Lipoblastoma and liposarcoma
children: An analysis of 9 cases and rewiew of the
literature. Can J Surg 1998; 41: 455-458.
CERRAHPAŞA TIP DERGİSİ Cilt (Sayı) 34 (3)
126
21. Mai KT, Yazdi HM, Collins JP. Vascular Myxolipoma
(AngioMyxolipoma) of the spermatic cord. Am J Surg
Pathol 1995; 20: 1272-1276.
22. Peulve P, Thomine E, Hemet J. Cytogenetic analysis of a
rare case of pediatric myxolipoma. Am Genet 1990; 33:
22-24.
23. Kilpatrick SE, Doyon J. Clinicopathologic spectrum of
myxoid and round cell liposarcoma: A Study of 395
cases. Cancer 1996; 77: 1450-1458.
24. Mentzel T. Cutaneous lipomatous neoplasms. Semin
Diagn Pathol 2001; 18: 250-257.
25. Guillou L, Coindre JM. Newly described adipocytic
lesions. Semin Diagn Pathol 2001; 18: 238-249.
26. Nielsen GP, O'Connell JX, Dickersin GR, Rosenberg AE.
Chondroid lipoma, a tumor of white fat cells. A brief
report of two cases with ultrastructural analysis. Am J
Surg Pathol 1995; 19: 1272-1276.
27. Marshall-Taylor C, Fanburg- Smith JC. Fibrohistiocytic
lipoma: twelve cases of previously undescribed benign
fatty tumor. Ann Diagn Pathol 2000; 4: 354-360.
28. Evans HL, Soule EH, Winkelmann RK.Atypical lipoma,
atypical intramuscular lipoma, and well differentiated
retroperitoneal liposarcoma: A reappraisal of 30 cases
formerly classified as well differentiated liposarcoma.
Cancer 1979; 43: 574-584.
29. Dei Tos AP: Liposarcoma: New entities and evolving
concepts. Ann Diagn Pathol 2000; 4: 252-266.
30. Challis D. Atypical subcutaneous fatty tumors. Adv Anat
Pathol 2000; 7: 94-99. (Review)
31. Allen PW, Strungs I, MacCormac LB. Atypical
subcutaneous fatty tumors: a review of 37 referred cases.
Pathology 1998; 30: 123-135.
32. Laurino L, Furlanetto A, Orvieto E, Del Tos AP. Welldifferentiated
liposarcoma (atypical lipomatous tumors).
Semin Diagn Pathol 2001; 18: 258-262. (Review)
33. Dei Tos AP, Mentzel T, Fletcher CD. Primary
liposarcoma of the skin: a rare neoplasm with unusual
high grade features. Am J Dermatopathol 1998; 20: 332-
338.

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