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SIÇANLARDA DENEYSEL BAKIR UYGULAMASININ OKSİDAN VE ANTİOKSİDAN SİSTEMLER ÜZERİNE ETKİLERİ

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Even though copper is necessary trace element for the organism, some recent studies report that copper may have some oxidative damage effects. Oxidative damage of copper has been reported in recent studies even though it is necessary for organism as a trace element. Present study has been planned to determine the oxidative effects of copper on blood and the defense system. Design.- In this study Wistar albino type female rats weighting 200-250g were used. The control (n=9) and experimental groups (n=9) were fed normal diet and water, the experimental group also received copper in their drinking water for nine weeks. After experimental period serum copper concentrations, erythrocyte superoxide dismutase (SOD) activity and glutathione (GSH) levels and plasma malondialdehyde (MDA) concentrations were measured in both group. Results.- MDA concentrations and SOD activities of experimental group were found higher than controls (p<0.05) and GSH concentration in experimental group was found to be lower than control group animals (p<0.05). Conclusion.- The results of this study may show that copper may lead to increase in lipid peroxidation and SOD activity and GSH levels may also be decreased by effect of copper in blood.
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Abstract (Original Language): 
Çalışmamız bakırın oksidatif ve defans sistemleri üzerindeki etkisini araştırmak amacıyla planlandı. Deney hayvanı olarak ağırlıkları 200-250 gr arasında değişen Wistar albino türü dişi sıçanlar kullanıldı. Kontrol sıçanlar normal diyet ve su ile beslenirken, deney grubunun içme sularına dokuz hafta süreyle bakır ilave edildi. Deney süresi sonunda her iki grubun serum bakır konsantrasyonu, SOD aktivitesi ve GSH düzeyleri ve plazma MDA konsantrasyonları ölçüldü. Bakır konsantrasyonu, MDA düzeyi ve SOD aktivitesinin deney grubunda kontrol grubuna göre yüksek olduğu saptandı (p<0.05). GSH düzeyi deney grubunda kontrol grubuna göre düşük bulundu (p<0.05). Çalışmanın sonucu olarak bakır uygulamasının kanda lipid peroksidasyonunu ve SOD enzim aktivitesini arttırdığını, GSH düzeyini azalttığını söyleyebiliriz.
FULL TEXT (PDF): 
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  • 4
185-187
  • Turkish

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