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CANDİDA ALBİCANS’DA MANNAN: ÇEŞİTLİ ÖZELLİKLERİ VE ÖNEMİ

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2004

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Candida albicans is both a commensal and opportunistic pathogen of humans. The outermost cellular structure, the cell wall play an essential role in the interactions with the host. Most of biological functions related to pathogenicity and virulence reside in the fungal cell wall. Mannoproteins, the major cell wall components of Candida albicans are a significant source of antigens. Both the carbohydrate and protein moieties are able to trigger immune response. The carbohydrate and/or protein parts may also be the candidal adhesin to bind host ligands and may contribute to hydrophobic interactions. Mannoprotein was demonstrated to cause haemolysis promoting the disruption of human red blood cells as well as to prevent phagocytosis. This review will adress the significanse features of Candida albicans cell wall mannoproteins.
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Abstract (Original Language): 
Candida albicans insanda hem kommensal hem de patojen olarak bulunabilen bir mantardır.Hücre yapısının en dışında bulunan hücre duvarı konak ile ilişkide önemli bir rol oynar. Patojenlik ve virulans ile ilgili biyolojik fonksiyonların bir çoğu hücre duvarında yerleşiktir. Candida albicans’ın başlıca hücre duvarı bileşenleri olan mannoproteinler önemli bir antijen kaynağıdır, hem karbonhidrat hem de protein kısımları bağışık yanıtı uyandırabilir. Karbonhidrat ve/veya protein kısımları Candida’yı konağın ligandlarına bağlayan adezinler olarak da işlev görebilirler ve hidrofobik etkileşime katılabilirler. Mannoproteinlerin insan kırmızı kan hücrelerini tahrip ederek hemolize yol açtıkları ve fagositozu önledikleri de gösterilmiştir. Bu yazıda Candida albicans’ın hücre duvarı mannoproteinlerinin önemli özellikleri gözden geçirilecektir.
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  • 1
37-42
  • Turkish

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