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SEKS HORMONLARININ DİŞİ TAVŞANLARDA MESANE FONKSİYONLARI ÜZERİNE ETKILERİ: ÜRODİNAMİ ÇALIŞMASI

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2004

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
We previously reported the effects of different sex hormones on bladder urodynamics in male rabbits. The aim of this study was to investigate the effects of different sex hormones on bladder urodynamics in female rabbits. Methods.- Mature female New Zealand white nonpregnant rabbits were studied in five groups. G-I: Sham operation {laparotomy (L)} + intramuscular 0.9% NaCl injection. G-II: L + Estrogen. G-III: L + Bilateral Oopherectomy (BO) + Estrogen. G-IV: L + BO + Progesterone. G-V: L + BO + Testosterone. Baseline urodynamic findings were recorded and the blood sex hormone levels were measured. All rabbits underwent urodynamic investigations on the 5th, 10th and 30th postinjection days. Blood levels of estrogen, progesterone and testosterone were also measured during the follow-up period. Results.- Blood levels of hormones were found increased on the 5th and 10th days after the injection, but decreased to normal level on the 30th day. There were no significant changes in bladder capacity and compliance in G-I. The bladder capacity and compliance were found to be increased in G-II and G-III on the 5th and 10th days (p<0.05). There were no significant changes in G-IV. There was an insignificant decline (p>0.05) in the bladder capacity and compliance on the 10th day in G-V. Conclusion.- There was a slight decrease in the bladder capacity and the compliance of the female rabbits after progesterone and testosterone injections. Contrary to this, there was an increase in the bladder capacity and the compliance correlated with the high blood level of estrogen hormone.
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Abstract (Original Language): 
Farklı seks hormonlarının kullanımı ile me-sanede, ürodinamik olarak kapasite ve kompli-ans değişiklikleri olmaktadır. Bu çalışmanın amacı, daha önce erkek tavşanlarda yaptığımız çalışmanın devamı olarak, seks hormonlarının dişi tavşan mesanesi üzerindeki ürodinamik etkilerini araştırmaktır. Çalışmamızda hamile olmayan Yeni Zelanda tipi beyaz dişi tavşanlar kullanıldı. Denekler beş ayrı gruba ayrıldı. G-I: Laparatomi (L) + %0,9NaCl. G-II: L + Östro-jen. G-III: L + Bilateral Ooferektomi (BO) + Östrojen. G-IV: L+BO+Progesteron. G-V: L + BO + Testesteron. Başlangıç kan seks hormon seviye tayini ve ürodinami uygulandı. Gruplar-da bütün deneklerin hormon enjeksiyonunu ta-kip eden 5. 10. ve 30. günlerde ürodinamik in-celemeleri tekrarlanarak kapasite ve komplians değerleri kaydedildi. Ayrıca takip süresince kan östrojen, progesteron ve testesteron seviye-leri düzenli olarak ölçüldü. Bulgular: Verilen tedaviler ile deneklerde 5. ve 10. günlerde kan hormon düzeylerinde artma saptanmış, bu de-ğerler 30. günün sonunda normal seviyelerine dönmüşlerdir. G-I: mesane kapasitesi ve komp-liansta belirgin bir değişiklik saptanmadı. G-II ve III: 5. ve 10. günlerde istatistiksel anlamlı mesane kapasite ve komplians artışı saptandı (p<0,005). G–IV: Komplians ve kapasite deği-şiklik saptanmadı. G-V: 10. günde mesanede kapasite ve komplians düştü, ancak bu düşüş istatistiksel olarak anlamlı değildi (p>0,005). Sonuç: Dişi tavşanlarda progesteron ve testos-teron uygulaması mesane kapasite ve kompli-ans değerlerinde hafifçe düşmeye, buna karşın östrojen ise artışa neden olmaktadır.
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http://www.ctf.edu.tr/dergi/online/2004v35/s2/a3.pdf
  • Turkish

REFERENCES

References: 

1. Batra SC, Iosif CS. Female urethra: a target for estrogen action. J Urol .1982; 129: 418-420.
2. Fantl JA, Wyman JF, Anderson RL, Matt DW, Bump RC. Postmenopausal urinary incontinence: Comparison between non-estrogen supplemented women. Obstet Gynecol. 1988; 71: 823- 828.
3. Iosif C S, Batra S, Ek A, Astedt B. Estrogen receptors in the human female lower urinary tract. Am J Obstet Gynecol. 1981; 141: 817-820.
4. Karram MM, Yeko TR, Sauer MV, Bhatia NN. Urodynamic changes following hormonal replacement therapy in women with premature ovarian failure. Obstet Gynecol. 1989; 74: 208- 211.
5. Raz S, Zeigler M, Caine M. The effect of progesterone on the adrenergic receptors of the urethra. Br J Urol. 1972; 45: 131- 135.
6. Salmon UJ, Walter RI, Geist SH. The use of estrogens in the treatment of dysuria and incontinence in postmenopausal women. Am J Obstet Gynecol .1941; 42: 845- 848.
7. Celayir S, Ilçe Z, Danişmend N. The effects of male sex hormones on urodynamics in childhood: Intersex patients are a natural model. Pediatr Surg Int. 2000; 16: 502- 505.
8. Celayir S, Ilçe Z, Balcı H, Altuğ T. Testesteron’un dişi tavşan mesanesi üzerindeki etkileri: Mesanenin cinsiyeti üzerine bir ön çalışma Pediatrik Cerrahi Dergisi. 2000; 14: 58- 62.
9. Anderson GF, Navarro SP. The response of autonomic receptors to castration and testosterone in the urinary bladder of the rabbit. J Urol. 1988; 140: 885- 889.
10. Cundiff GW, Harris RL, Coates KW, Bump RC. Clinical predictors of urinary incontinence in women. Am J Obstet Gynecol. 1997; 177: 262-267.
11. Levin RM, Ruggieri MR, Wein AJ. Identification of receptor subtypes in the rabbit and human urinary bladder by selective radio-ligand binding. J Urol. 1988; 139: 844- 848.
12. Levin RM, Shofer FS, Wein AJ. Estrogen-induced alterations in the autonomic responses of the rabbit urinary bladder. J Pharmacol Exp Ther. 1980; 215: 614- 618.
13. Morita T, Masuda H, Tosaka A, Ishizaka K, Tsujii T, Kondo S. Sex differences in function of b-adrenoceptors in rabbit urinary bladder. J Urol. 1998; 159: 555.
14. Morita T, Latifpour J, O’Hollaren B, Wheeler MA, Weiss RM. Sex difference in function and distribution of a-1 and a-2 adrenoceptors in rabbit urethra. Am J Physiol. 1987; 252: 1124- 1129
15. Ekström J, Iosif CS, Malmberg L. Effects of long term treatment with estrogen and progesterone on in vitro muscle responses of the female rabbit urinary bladder and urethra to autonomic drugs and nerve stimulation. J Urol . 1993; 150: 1284-1288.
16. Iosif S. Stress incontinence during pregnancy and in puerperium. Int J Gynaecol Obstet. 1981; 19: 13- 15.
17. Habib M, Krasnopolsky L, Gaafar S, Levin RM. Comparative studies on urethral function. World J Urol . 1996; 14: 388- 392.
18. Rosenzweig BA, Bolina PS, Birch L, Moran C, Marcovici I, Prins GS. Location and concentration of estrogen, progesterone, and androgen receptors in the bladder and urethra of the rabbit. Neurourol Urodyn. 1995; 14: 87- 96.
19. Celayir S, Kılıç N, Söylet Y, Büyükünal SNC. Urodynamic findings in rabbit bladder. Pediatrik Cerrahi Dergisi. 1996; 10: 71-73.
20. Fantl JA, Cardozo L, McClish DK. The hormones and urogenital therapy committee. Estrogen therapy in the management of urinary incontinence in postmenopausal women: A meta-analysis. First report of the hormones and urogenital therapy committee. Obstet Gynaecol. 1994; 83: 12-18.
21. Pacchioni D, Revelli A, Casetta G. Immunohistochemical detection of estrogen and progesterone receptors in the normal urinary bladder and in pseudomembranous trigonitis. J Endocrinol Invest. 1992; 15: 719-725.
22. Salmon UJ, Walter RI, Geist SH. The use of estrogens in the treatment of dysuria and incontinence in postmenopausal women. Am J Obstet Gynecol .1941; 42: 845- 848.
23. Celayir S, Ilçe Z, Dervisoglu S. The Sex Hormone Receptors in Bladder in Childhood - I: Preliminary Report in Male Subjects. Eur J Pediatr Surg. 2002; 12: 312-317.
24. Wolf H, Wandt H, Jonat W. Immunohistochemical evidence of estrogen and progesterone receptors in the female lower urinary tract and comparison with the vagina. Gynecol Obstet Invest. 1991; 32: 227- 231.

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