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LİZENSEFALİ VE OTİZM: OLGU SUNUMU

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2005

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Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Lissencephaly is one of the most severe developmental brain malformations caused by incomplete neuronal migration, and characterized by loss of the normal gyral patterns in the cerebral hemispheres, prominent disorganization of the cerebral cortical cytoarchitecture, and generally associated with profound neurologic deficits and epilepsy. Affected patients usually exhibit severe delay in cognitive development and refractory epileptic seizures. Neuronal migration anomalies are important in the differential etiological diagnosis of cognitive dysfunctions including symptomatic autism. In this report, we present a case diagnosed as isolated diffuse lissencephaly, who admitted with the complaints of mental-motor retardation, and autistic disorder.
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Abstract (Original Language): 
Lizensefali, intrauterin beyin gelişiminin migrasyon döneminde görülen en ağır sorunla-rından biri olup, serebral hemisferlerde normal girus paterninin kaybı, serebral kortikal mima-rinin dizorganizasyonu, sıklıkla eşlik eden ağır nörolojik defisit ve nöbetlerle şekillenen ağır gelişimsel beyin anomalisidir. Etkilenen kişi-lerde çoğunlukla ağır mental rötardasyon ve di-rençli epilepsi nöbetleri görülür. Nöronal mig-rasyon anomalileri otizm de dahil olmak üzere çeşitli düzeylerde bilişsel etkilenmenin etiyolo- Ocak-Mart 2005 LİZENSEFALİ VE OTİZM; BENBİR VE KORKMAZ 53 jik ayırıcı tanısında önemli bir yer tutmaktadır. Bu yazıda, epilepsi, motor-mental rötardasyon ve otistik bozukluk şikayetleri ile başvuran izo-le yaygın lizensefali olgusu sunulmaktadır.
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  • 1
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  • Turkish

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