Buradasınız

Anasayfa » Content

Anesteziye Tavşanlarda Santral Serotoninin Solunum Düzenlemesindeki Rolü

The Role of Central Serotonin on Respiratory Regulation in Anaesthetized Rabbits.

Journal Name:

  • Cerrahpaşa Tıp Dergisi

Publication Year:

  • 2006

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
In the present study, we aimed to investigate the effect of central exogenous serotonin (5-HT) on ventilation during normoxia and hypoxia. The experiments were performed in peripheral chemoreceptors intact rabbits anesthetized with urethane (400 mg/kg I.V) and alpha-chloralose (40 mg/kg I.V). For intracerebroventricular (ICV) administration of serotonin (5-HT), a cannula was placed intracerebroventricularly to the left lateral ventricle with stereotaxy. Respiratory frequency (f/min), tidal volume (VT), ventilation minute volume (VE) and systemic arterial blood pressure (BP) were recorded and mean arterial pressure was calculated (MAP). ICV administration of 5-HT (20 μg/kg) caused an increased in f/dk ,VT and VE. After ICV administration of 5-HT, breathing of hypoxic gas mixture (8 % O2 - 92 % N2) produced an increase in hypoxic respiratory responses. ICV ketanserin administration (5-HT2A/2C receptor antagonist, 10 (g/kg), in rabbits caused a decrease in f/min, VT, and VE. ICV ketanserin also prevented the stimulatory effect of 5-HT on ventilation during normoxia. In conclussion, the results of this study show that 5-HT increases ventilation during normoxia and hypoxia via 5-HT2 receptors.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-anesteziye-tavsanlarda-santral-serotoninin-solunum-duzenlemesindeki-rolu.pdf
  • 3
98 - 102
  • Turkish

REFERENCES

References: 

1. Herman JK, O'Halloren KD, Mitchell GS, and et al.
Methysergide augments the acute, but not thesustained,
hypoxic ventilatory response in goat. Respir
Physiol 1999; 118: 25-37.
2. Richter DW, Manzke T, Wilken B, and et al. Serotonin
receptors: guardians of stable breathing. Trends Mol
Med 2003; 9: 542-548.
3. Richter DW, Schmidt-Garcon P, Pierrefiche O, and
et al. Neurotransmitters and neuromodulators controlling
the hypoxic respiratory response in anaesthetized
cats. J Physiol 1999; 514: 567-578. .
4. Lambert GA, Friedman E, Buchweitz E, and et al.
Involvement of 5-hydroxytryptamine in the central
of respiration, blood pressure and heart rate in the
anaesthetized rat. Neuropharmacol 1978; 17: 807-813.
5. Lindsay AD, Feldman JL. Modulation of respiratory
activity of neonatalrat phrenic motoneuronesby
serotonin. J Physiol 1993; 461: 213-233. .
6. Cayetanot F, Bodineau L, Frugiere A. 5-HT acting
on 5-HT1/2 receptors does not participate in the in
vitro hypoxic respiratory depression. Neurosci Res
2001; 41: 71-78.
7. Bodineau L, Cayetanot F, Marlot D, and et al. Endogenous
5-HT1/2 systems and the newborn rat respiratory
control a comparative in vivo and in vitro
study. Respir. Physiol. Neurobiol 2004; 141: 47-57..
8. Lin LS, Lin MT. Hypothalamic serotonin release and
raised blood pressure after raphe nuclei stimulation
in rats. Brain Res Bull 1996; 39: 305-309. .
9. Lindsay AD, Feldman JL. Modulation of respiratory
activity of neonatalrat phrenic motoneuronesby
serotonin. J Physiol 1993; 461: 213-233. .
10. fiahin G, Terzio¤lu M. The influence of chronic hypoxia
on erytyrocytic 2.3 diphospho glycreate and
the sensitivity of peripheral chemoreceptors of rabbits.
Cerrahpafla Med Rev 1985; 4: 46-56. .
11. Millhorn DE, Elridge FL, Waldrop TG, and et al.
Centrally and peripherally administired 5-http have
opposite effects on respiration. Brain Res 1983; 264:
349-354.
12. Lalley PM, Benecka R, Bischoff AM, and et al. Nucleus
raphe obscurus evokes 5-HT-1A receptor-mediatedmodulationof
respiratory neurons. Brain Res 1997;
747: 156-159.
13. Richter DW, Lalley PM, Pierrefiche O, and at al.
Intracellular signal pathways controlling respiratory
neurons. Respir Physiol 1997; 110: 113-123. .
14. Underwood MD, Arango V, Bakalian Y, and et al.
Dorsal raphe nucleus serotoninergic neurons innervate
the rostral ventrolateral medulla in rat. Brain
Res 1999; 824: 45-55.
15. Iwahori Y, Ikegaya Y, Matsuki N. Hyperpolarization-
Activated current Ih in nucleus of solitary tract neurons:
Regional difference in serotonergic modulation.
Jpn J Pharmacol 2002; 88: 459-462. .
16. Oruç T, Terzio¤lu M, fiahin G, and et al. Response
of the central respiratory control mechanism to hyperoxia
and hypoxia. Bull Europ Physiopath Resp 1982;
18: 439-447.
17. Pena F, Ramirez JM. Endogenous activation of serotonin-
2A receptors is required for respiratory rhythm
generation in vitro. J Neurosci 2002; 22: 11055-
11064.
18. N'Diaye A, Sevoz CC, Nosjean A, and et al. Stimulation
of 5-HT2 recept›rs in the nucleus tractus solitarius
enhances NMDA receptors-mediated reflexevoked
bradycardiac responses in the rat. Auton
Neurosci 2001; 92: 45-55.

Thank you for copying data from http://www.arastirmax.com