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ÇAPRAZ TASARIMIN KLİNİK ARAŞTIRMALARDA UYGULANMASI

APPLICATION OF CROSSOVER DESIGN IN CLINICAL RESEARCHES

Journal Name:

  • Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi

Publication Year:

  • 2006

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The crossover design describes experiments with treatments administered in sequence to each experimental unit. A treatment is administered to an experimental unit for a specific period of time after which another treatment is administered to the same unit. The treatments are successively administered to the unit until it has received all treatments. The most popular crossover design is the 2-sequence, 2-period, 2-treatment crossover design. Crossover designs have been the most popular designs of choice in many clinical and pharmaceutical trials. The aim of this paper is to scrutinize the basic information about crossover designs, to explain how to use crossover designs in clinical researches, and to inform about crossover design application and its results realized on one of the clinical trial.
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Abstract (Original Language): 
Çapraz tasarım, her bir deney birimine belirli bir sıra ile uygulanan denemeleri içeren deneyleri açıklamaktadır. Bu tasarımda bir deneme, belirli bir zaman periyodunda bir deney birimine uygulandıktan sonra aynı birime bir sonraki periyotta başka bir deneme uygulanmaktadır. Denemeler deneyin uygulandığı birim, tüm denemeleri alıncaya kadar ardışık olarak uygulanır. En yaygın çapraz tasarım türü 2-sıra, 2-periyot, 2-deneme çapraz tasarımdır. Çapraz tasarımlar, çok sayıda klinik ve farmakolojik denemelerde seçilen en yaygın tasarımlar olmuştur. Bu makalenin amacı çapraz tasarımlar hakkındaki temel bilgileri gözden geçirmek, çapraz tasarımların klinik araştırmalarda nasıl uygulandığını açıklamak, ve bir klinik denemede gerçekleştirilen çapraz tasarım uygulaması ve sonuçları hakkında bilgi vermektir.
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  • 3
51-64
  • Turkish

REFERENCES

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