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Başarılı Perkütan Transluminal Koroner Anjiyoplastinin QT Dispersiyonu Üzerine Etkisi ve Restenozla Değişimi

Effect of Successful Percutaneous Transluminal Coronary Angioplasty on QT Dispersion and Changes with Restenosis

Journal Name:

  • Fırat Tıp Dergisi

Publication Year:

  • 2007

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Abstract (2. Language): 
Objectives: The objective of this study was to describe the effect of successful percutaneous transluminal coronary angioplasty (PTCA) on QT dispersion and to see the changes with restenosis. In addition, we tried to research feasibility of QT and QTc dispersion as a useful noninvasive method to determine restenosis. Material and Methods: 34 patients who were decided for PTCA after coronary angiography were included in this study. Prior to PTCA, in the first 24 hour after the procedure and at 3 or 6 months interval twelve-lead electrocardiograms (ECG) of every patient at 50 mm/sec were recorded. During follow up period, coronary angiography was applied to 13 patients due to symptoms and stress test results and 9 of these had stenosis and 4 normal coronary arteries. Results: A significant reduction in QT dispersion (QTd) and corrected QT dispersion (QTcd) in the first 24 hours after PTCA was observed and during the succeeding period mean 4 months (3 to 6) these values didn't change if there is no restenosis. Developing restenosis caused an important increase in QTd and QTcd values. Conclusion Reduction in QTd after PTCA may prevent unwanted events like sudden cardiac death and malignant ventricular arrhythmias. With developing restenosis QT dispersion increases and we think that to follow up after PTCA or to determine restenosis after revascularization QT dispersion may be used as a noninvasive method. ©200007, Firat University, Medical Faculty
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Abstract (Original Language): 
Giriş: Çalışmada amaç koroner arter hastalarında başarılı perkütan transluminal koroner anjiyoplasti'nin (PTKA) QT dispersiyonu ve hıza göre düzeltilmiş QT dispersiyonu üzerine etkisini ve takipte de restenozla değişimini araştırmaktı. Bu şekilde PTKA sonrası takipte QT dispersiyonu ve düzeltilmiş QT dispersiyonu değerinin noninvaziv bir yöntem olarak kullanılabilirliği sorgulandı Gereç ve Yöntem: Çalışmaya koroner anjiyografileri yapılıp PTKA kararı alınan 34 hasta alındı. PTKA öncesi ve işlem sonrası ilk 24 saat içinde 50 mm/sn hızında birer elektrokardiyografi (EKG) kaydı alındı ve daha sonra belirti yoksa 3. ile 6.ayda kontrollere çağrıldı (ortalama 4 ay) ve bu hastalardan birer EKG kaydı daha alındı. Alınan EKG kayıtlarından ortalama QT dispersiyonu (QTd) ve düzeltilmiş QT dispersiyonu (QTcd) hesaplandı. İzlemde efor testi pozitifliği veya belirtiler nedeniyle 13 hastaya kontrol koroner anjiyografi yapıldı. Koroner anjiyografi sonucuna göre restenoz veya normal koroner arter saptanan hastaların QTd ve QTcd değerleri hesaplandı Bulgular: Yapılan ölçümlerde PTKA öncesi ve sonrası karşılaştırıldığında ilk 24 saatte QTd ve QTcd belirgin olarak azaldı. Uzun dönem takipte restenoz saptanan hastalarda hesaplanan QTd işlem öncesi değerlere yaklaşmıştı. QTcd değerinin de aynı şekilde PTKA ile azaldığı ve restenoz gelişmesiyle de arttığı görüldü. Sonuç: PTKA sonrası iskeminin giderilmesi ile QTd ve QTcd azalır; bununla birlikte restenozun gelişmesiyle QTd ve QTcd artar. Artmış QTd değerleri ani ölüm ve ventriküler taşikardiyle ilişkili bulunmuştur. PTKA sonrası takipte ve önemli bir sorun olan restenozun saptanmasında QTd değerlerinin yol gösterici noninvaziv bir yöntem olabileceğini düşünmekteyiz. ©2007, Fırat Üniversitesi, Tıp Fakültesi
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REFERENCES

References: 

1. Higham PD, Campbell RWF. QT dispersion. Br. Heart J 1994; 71:508
2. Gernlernter DW, Michael C, Higman H A. Regional myocardial dysfunction during coronary angioplasty: Evaluation by two-dimensional Echocardiography and 12 lead elecctrocardiography.
J Am Coll Cardiol 1986; 7:1245-54
3. Joseph son MA, Singh BN. Abolition of holter monitor detected after percutaneous transluminal coronary angioplasty. J Am Coll
Cardiol 1987; 10: 499-503
4. Day CP, McComb JM, Campbell RWF. QT dispersion: an
indication of arrhythmia risk in patients with long QT intervals. Br Heart J 1990; 63: 342-8
5. Higham PD, Furniss S, Campbell RWF. QT dispersion and components of the QT interval in ischemia and infarction. Br
Heart J 1995; 73:32
6. Yuan S, Blomstom-Lundquist C, Pripp C-M et al. Signed value of monophasic action potential duration difference: A useful measure in evaluation of dispersion of repolarization in patients with ventricular arrhythmias. Eur Heart 1997; 18:1329-38
7. Priori SG, Napolitano C, Dieht L, Schwartz P. Dispersion of the QT interval: A marker of therapeutic efficiency in the idiopathic long QT syndrome .Circulation 1994,89;1681-1689
8. Okishige Kaoru, Yamoshita Katsuhiro,Yashinaga Haruhiko, Azegami Kauji. Effects of ischemic preconditioning an QT dispersion during coronary angioplasty. J Am Coll Cardiol 1996;
28:70-3
9. Molnar J, Weiss J,Zhang F, et al. Evaluation of fine QT correction formulas using a software-assisted method for continuous QT measurements from 24-hour holter recordings.
Am J Cardiol 1996; 78:920-6
208
Fırat Tıp Dergisi 2007;12(3):206-209
Karadağ Kutlu
10. Franz MR. Time for yet another QT correction algorithm? Bazett
and beyond. J Am Coll Cardiol 1994;23:1554-7
11. Higham PD, Hilton Cj, Aitcheson JD, Furniss SS et al: Does QT
dispersion reflect dispersion of ventricular recovery? Circulation
1992; 86(supp): 392
12. Elming H, Holm f, Jun L, et al The prognostic value of the QT interval and QT interval dispersion in all cause and cardiac mortality and morbidity in a population of Danish citizens. Eur Heart j 1998; 19:1391-1400
13. Schouten EG, Dekker JM, Kok FJ. QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Circulation 1991; 84:1516-23
14. Lee HS, Cross SJ, Rawles J, Walton s, Jennings KP. QT
dispersion in patients with coronary artery disease - effect of exercise , dobutamine and dipyridamole myocardial stress eur
Heart J 1993;14:210
15. Dekker JM, Schouten EG, Klootwijk P. Association between QT interval and coronary heart disease in middle aged and elderly
men. Circulation 1994; 90:779-85
16. Vloka ME, Steinberg JS. QT dispersion current and future clinical role. J Invas Cardiol 1996;8:363-69
17. Doi Y, Takada K, Mihara H,et al.QT dispersion in acute myocardial infarction with special reference to left ventrikolographic findings. Jpn Heart J 1995;36:573-581
18. Barr CS, et al.QT dispersion and sudden unexpected death in chronic heart failure . Lancet 1994;343:327-29
19. Surawicz B. Electrophysiological basis of ECG and cardiac arrhythmias Malvern. William and Wilkins 1995
20. Furukawa t, Kimura S, Curveas J, et al. Role of cardiac ATP regulated potassium channels in differential responses of endocardial and epicardial cells to ischemia.Circ Res 1991; 68:1693-1702
21. Yunus A, Gillis AM,Traboulsi M, et al. Effecy of coronary angioplasty on QT dispersion. Am J Cardiol 1997;79:1339
22. Kelly FR, Parillo EJ, Hollenberg SM. Effect of coronary angioplasty on QT dispersion . AM Heart J 1994;134:399-405
23. Califf RM; Restenosis the clinical issue. In Topol E j(ed): Textbook of interventional cardiology second edition. Philadelphia, W B Saunders Company 1993,p 415
24. Serruys PW, Ljuytes HE, Beatt K J, et al. Incidence of restenosis after successful coronary angiography: A time related phenomenon: A quantitative angiographic study in 342 consecutive patients at 1,2,3 and 4 months. Circulation 1988;
77:361

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