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Diyabetik Anne Bebeğinde Klinik ve Laboratuar Bulguları

The Laboratory and Clinical Findings in Infants Born to Diabetic Mothers

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Abstract (2. Language): 
Objectives: The risk ratio for maternal hyperglycemia has been decreased with special care of diabetic mothers. But, the morbidity rate of infants born to diabetic mothers (DAB) is still high. The malformation ratio has been reported as 8% in infants of insulin dependent diabetic (IDDM) mothers. In this study, it was aimed to determine the clinical and laboratory findings in infants of diabetic mothers, demographic characteristics of these mothers and discuss the association of values between these groups. Materials and Methods: Total 22 infants born to mothers with diabetes mellitus were included in this study. Two (9%) of 22 mothers had been diagnosed with IDDM and twenty (92%) with gestational diabetes. Results: There was correlation between congenital malformation and duration of diabetes of mothers. No correlation were detected between HbAlc levels of mothers and respiratory distress syndrome, hypoglycemia, hypocalcaemia and polycythemia in infants. There was a positive correlation between the HbAlc levels of mothers and frequency of newborn jaundice. Hypoglycemia was detected in 34.5% of patients, hyperbilirubinemia in 50%, cardiac murmur in 32% RDS in 18%,delivery trauma in 14%, hypocalcaemia in 9%, polycythemia in 9%, thrombocytopenia in 4.5% and, hypothermia in 4.5% respectively. The malformation ratio was determined as 22% and the mortality rate 9%. Conclusion: The metabolic control of diabetic mothers should be made carefully during pregnancy. Perinatal mortality rate may be decreased with balance fetal weight gain. However, the other probable complications that not preventive. ©200008, Firat University, Medical Faculty.
Abstract (Original Language): 
Amaç: Diyabetik annelerin gebelikte dikkatli izlemi ile maternal hiperglisemi azaltılmıştır. Buna rağmen diyabetik anne bebeği (DAB)'nde morbidite önemli oranda devam etmektedir. İnsüline bağımlı diyabet (IDDM) olan annelerin bebeklerinde malformasyon oranı %8 olarak saptanmıştır. Bizde, DAB'nde görülen klinik ve laboratuar bulguları ile; annelere ait demografik özellikleri ve bunların birbirleri ile ilişkilerini belirlemek istedik. Gereç ve Yöntem: Toplam 22 DAB değerlendirildi. Annelerden 2 (%9)'si IDDM ve 20 (%92)'si gestasyonel diyabet tanısı ile takip edilmekte idi. Bulgular: Annenin diyabet süresinin artması ile konjenital malformasyonlar arası ilişki saptanmadı. Annenin HbAlc seviyesi ile respiratuar distres sendromu, hipoglisemi, hipokalsemi ve polisitemi gelişimi arasında ilişki saptanmadı. Annenin HbAlc düzeyi arttıkça yenidoğan sarılığı görülme sıklığında artma saptandı (p<0.05). Hipoglisemi %54.5, hiperbilirubinemi %50, kardiyak üfürüm %32, RDS %18, doğum travması %14, hipokalsemi %9, polisitemi %9, trombositopeni %4.5 ve hipotermi %4.5 oranında saptandı. Malformasyon %22 ve mortalite %9 oranında bulundu. Sonuç: Hamilelik süresince diyabetik annenin metabolik kontrolü dikkatli yapılmalıdır. Fetal ağırlık artışı dengelenerek perinatal ölümler azaltılabilir. Buna rağmen DAB'nde beklenen diğer bulgular önlenemeyebilir..©2008, Fırat Üniversitesi, Tıp Fakültesi

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