Buradasınız

Menenjiomlarda Difüzyon Ağırlıklı MRG Bulgularının Histopatolojik Sonuçlarla Karşılaştırılması

Diffusion-weighted MRI of Meningiomas: Correlation with Histopathologic Results

Journal Name:

Publication Year:

Abstract (2. Language): 
Diffusion-weighted MRI of Meningiomas: Correlation with Histopathologic Results Objective: The purpose of this study was to determinate the contribution of diffusion-weighted (DW) magnetic resonance imaging (MRI) to the differentiation of atypical and typical meningiomas and to the determination of histological subtypes of typical meningiomas. Materials and Methods: Fourteen patients (age range between 37-77) with meningiomas were included to this study. Using routine MRI sequences, meningiomas were diagnosed and DW images were performed using factor of b-0 and b-1000. Apparent diffusion coefficient (ADC) values were measured in the lesion, normal area of parenchyma and peritumoral edema. Student t-test was used for statistical analysis. P<0.05 was considered significant. Results: ADC value of atypical case was 0.27x10-3 mm2/sec. This value was lower than ADC values of typical meningiomas and normal parenchymal area. Mean ADC value of typical cases was 1.08x10-3 mm2/sec. The difference between the subtypes of typical meningiomas was insignificant. Also, the difference between ADC values of peritumoral edema and lesions was insignificant. ADC values of typical meningiomas were higher than ADC values of normal area and these values were statistically significant. Conclusion: Typical meningiomas had higher ADC values than atypical case. DW MRI may be contribute to difference between typical and atypical meningiomas
Abstract (Original Language): 
Amaç: Çalışmanın amacı atipik ve tipik menenjiomların ayrımında ve tipik menenjiomların alt tiplerinin ayrımında difüzyon ağırlıklı (DA) manyetik rezonans görüntüleme (MRG)'nin tanıya olan katkılarını saptamaktır. Gereç ve Yöntem: Yaşları 34 ile 77 yaş arasındaki değişen 14 menenjiom olgusu çalışmaya dahil edildi. Rutin MRG sekansları ile menenjiomlar tanımlandı ve b-0, b-1000 faktör değerlerinde DA MRG sekanslar elde edildi. Lezyon içerisinden, lezyon komşuluğundaki normal parankim alanından ve peritümöral ödemden aşikar difüzyon katsayısı (ADC) ölçümleri yapıldı. Student t-testi kullanılarak istatistiksel analiz yapıldı. P<0.05 anlamlı kabul edildi. Bulgular: Atipik olgunun ADC değeri 0.27x10-3 mm2/saniye olarak bulundu. Bu değer normal parankimden elde edilen ADC değerinden ve tipik menenjiomların ADC değerinden daha düşüktü. Tipik Menenjiomların ortalama ADC değerleri 1.08x10-3 mm2/saniye olarak bulundu. Tipik Menenjiomların subtipleri arasında istatistiksel olarak belirgin farklılık saptanmadı. Yine lezyon çevresindeki ödem alanı ile lezyondan ölçülen ADC değerleri arasındaki farklılık istatistiksel olarak anlamlı değildi. Ancak tipik Menenjiomların ADC değeri normal alandan yapılan ADC değerinden yüksek olup bu farklılık istatistiksel olarak anlamlıydı. Sonuç: Tipik menenjiomlar atipik menenjiomdan daha yüksek ADC değerine sahiptir. DA MRG atipik ve tipik Menenjiomların ayrımında katkıda bulunabilir.
47-51

REFERENCES

References: 

1. Mahmood A, Caccamo DV, Tomecek FJ, Malik GM. Atypical and malignant meningiomas: a clinicopathological review. Neurosurgery 1993; 33: 955-963.
2. Hakyemez B, Yildirim N, Gokalp G, Erdogan C, Parlak M. The contribution of diffusion-weighted MR imaging to distinguishing typical from atypical meningiomas. Neuroradiology 2006; 48: 513-520.
3. Verheggen R, Finkenstaedt M, Bockermann V, Markakis E. Atypical and malignant meningiomas: evaluation of different radiological criteria based on CT and MRI. Acta Neurochir
1996; 65: 66-69.
4. Carpeggiani P, Crisi G, Trevisan C. MRI of intracranial meningiomas: correlation with histology and physical consistency. Neuroradiology 1993; 35: 532-536.
5. Le Bihan D, Breton E, Lallemand D, et al. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 1988; 168: 497-505.
6. Tien RD, Felsberg GJ, Friedman H, Brown M, Mac Fall J. MR
imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences. AJR Am J Roentgenol 1994; 162: 671-677.
7. Chenevert TL, Mc Keever PE, Ross BD. Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging. Clin Cancer Res 1997; 3: 1457-1466.
8. Harting I, Hartmann M, Bonsanto MM, Sommer C, Sartor K. Characterization of necrotic meningioma using diffusion MRI, perfusion MRI, and MR spectroscopy: case report and review of the literature. Neuroradiology 2004; 46: 189-193.
9. Filippi CG, Edgar MA, Ulug AM, et al. Appearance of meningiomas on diffusion-weighted images: correlating diffusion constants with histopathologic findings. AJNR Am J
Neuroradiol 2001; 22: 65-72.
10. Ada
E
. Santral Sinir Sistemi Enfeksiyonlarında Görüntüleme Yöntemleri. Turkiye Klinikleri J Int Med Sci 2006; 2: 11-18.
11. Eis M, Els T, Hoehn-Berlage M, Hossmann KA. Quantitative diffusion MR imaging of cerebral tumor and edema. Acta Neurochir Suppl 1994; 60: 344-346.
Bozgeyik ve Ark.
12. Els T, Eis M, Hoehn-Berlage M, Hossmann KA. Diffusion-weighted MR imaging of experimental brain tumors in rats.
MAGMA 1995; 3: 13-20.
13. Sugahara T, Korogi Y, Kochi M, et al. Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging 1999; 9: 53-60.
14. Kleihues P, Cavenee WK. Pathology and genetics of tumours of the nervous system. 1st ed. Lyon: IARC Pres, 2000.
15. Montriwiwatchai P, Kasantikul V, Taecholarn C. Clinicopathological features predicting recurrence of intracranial meningiomas. J Med Assoc Thai 1997; 80: 473-478.
16.
Kur
t G, Emmez H, Öztanır N, Baykaner MK, Çeviker N. Serebral Arteriyovenöz Malformasyonlarda Gamma Knife Radyocerrahisi. Turkiye Klinikleri J Surg Med Sci 2006; 2:
93-96.
17. Lobato RD, Alday R, Gomez PA, et al. Brain edema in patients with intracranial meningioma. Correlation between clinical, radiological, and histological factors and the presence and intensity of oedema. Acta Neurochir 1996; 138: 485-493.
18. Buetow MP, Buetow PC, Smirniotopoulos JG. Typical, atypical, and misleading features in meningioma. Radiograp-hics 1991; 11: 1087-1106.
19. Vorisek I, Hâjek M, Tintera J, Nicolay K, Sykovâ E. Water ADC, extracellular space volume, and tortuosity in the rat cortex after traumatic injury. Magn Reson Med 2002; 48: 994¬1003.
20. Louis DN, Scheithauer BW, Budka H, von Deimling A, Kepes JJ. Meningiomas. In: Kleihues P, Cavenee WK, eds. World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Central Nervous System. Lyon: IARC Pres, 2000: 176-184.
21. Yamasaki F, Kurisu K, Satoh K, et al. Apparent diffusion coefficient of human brain tumors at MR imaging. Radiology
2005; 235: 985-991.

Thank you for copying data from http://www.arastirmax.com