Buradasınız

Anasayfa » Content

Kronik Renal Yetmezlikli Bir Olguda Antitüberküloz Tedaviye Bağlı Serebellit Gelişimi

Cerebellitis due to Antituberculosis Therapy in a Patient with Chronic Renal Failure

Journal Name:

  • Fırat Tıp Dergisi

Publication Year:

  • 2009

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The incidence of tuberculosis in patients treated with hemodialysis for chronic renal failure is higher than in the general population. Further, those patients often experience adverse effects from therapy with anti-tuberculosis drugs. Although the ototoxicity and toxic retinopathy caused by antituberculosis drugs is well known, the cerebellar syndrome is rare. We presented a 50-year-old woman developed cerebellar ataxia who was on hemodialysis program and taking anti-tuberculosis drugs combination therapy. Brain magnetic resonance imaging showed cerebellar edema. Cerebellar signs partially reversed after discontinuation of anti-tuberculosis therapy and initiation of pyridoxine therapy. In our patient, isoniazid was probably the drug that caused cerebellar signs and symptoms. In conclusion, a diagnosis of isoniazid-induced cerebellitis should be considered when cerebellar signs develop in patients undergoing hemodialysis and treated with isoniazid.
Bookmark/Search this post with
Abstract (Original Language): 
Kronik böbrek yetmezlik nedeniyle diyalize giren olgularda tüberküloz insidansı normal popülasyona göre artmıştır. Ayrıca bu olgularda antitüberküloz ilaçların yan etkileri daha fazla görülür. Ototoksite ve toksik retinopati antitüberküloz ilaçların iyi bilinen yan etkileri olmasına rağmen, serebellar sendrom nadiren karşımıza çıkar. Biz bu sunumda, antitüberküloz tedavi sırasında serebellar ataksi gelişen ve kronik böbrek yetmezliği olan 50 yaşında kadın olgunun bulgularını tartıştık. Beyin manyetik rezonans görüntülenmesinde serebellar ödem saptandı. Antitüberküloz ilaç teda¬ visinin kesilmesi ve piridoksin tedavisinin başlamasıyla serebellar bulgularda kısmen düzelme izlendi. Bizim hastamızdaki serebellar bulgular olası¬ lıkla izoniazid toksitesine sekonder gelişti. Sonuç olarak, izoniazid tedavisi alan diyalize giren olgularda serebellar bulgular geliştiğinde, izoniazid toksitesine bağlı serebellit tanısı akılda tutulmalıdır.
FULL TEXT (PDF): 
PDF icon arastirmax-kronik-renal-yetmezlikli-bir-olguda-antituberkuloz-tedaviye-bagli-serebellit-gelisimi.pdf
  • 4
290-292
  • Turkish

REFERENCES

References: 

Siskind MS, Thienemann D, Kirlin L. Isoniazid-induced neurotoxicity in chronic dialysis patients: report of three cases and a review of the literature. Nephron 1993;64:303-306.
Quantrill SJ, Woodhead MA, Bell CE, Hardy CC, Hutchison AJ, Gokal R. Side-effects of antituberculosis drug treatment in patients with chronic renal failure. Eur Respir J 2002; 20:440¬443.
Hussein MM, Mooij JM, Roujouleh H. Tuberculosis chronic renal disease. Semin Dial 2003; 16:38-44.
and
Cheung WC, Lo CY, Lo WK, Ip M, Cheng IK. Isoniazid induced encephalopathy in dialysis patients. Tuber Lung Dis 1993; 74:136-139.
Blumberg EA, Gil RA. Cerebellar syndrome caused by isoniazid. DICP 1990;24:829-831.
Tostmann A, Boeree MJ, Aarnoutse RE, et al. Antituberculosis drug-induced hepatotoxicity: concise up-to-date review. J Gastroenterol Hepatol. 2008 ;23:192-202.
Lheureux P, Penaloza A, Gris M. Pyridoxine in clinical toxicology: a review. Eur J Emerg Med 2005;12:78-85.
De
Bruecke
r Y, Claus F, Demaerel P,et al. MRI findings in acute cerebellitis. Eur Radiol 2004; 14:1478-1483.

Thank you for copying data from http://www.arastirmax.com