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Behçet üveit olgularında serum nitrik oksid düzeyi ile üveit aktivitesi arasındaki ilişkinin değerlendirilmesi

Evaluation of the relationship between serum nitric oxide levels and uveitis activity in patients with Behçet uveitis

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2006

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
In this study, we aimed to detect the relationship between serum nitric oxide levels and disease activity in patients with Behçet uveitis. Twenty-five patients with active uveitis diagnosed by clinical examination and fundus fluorescein angiography, and 10 inactive Behçet patients without any attack in the last 12 months were included in the study. Nineteen age- and sex-matched healthy volunteers without any ocular or systemic pathologies were chosen as the control group. Serum nitrite levels were measured with Griess reaction. Nitric oxide levels were compared with serum C-reactive protein, α-1 antytripsin and ceruloplasmin levels. No significant differences were found among active Behçet uveitis patients, inactive Behçet patients and the control group with respect to serum nitrite levels (p=0.883), whereas serum C-reactive protein and α- 1 antytripsin levels were significantly higher in active Behçet uveitis patients (p=0.003 ve p=0.01). The differences between the ceruloplasmin levels were not statistically significant (p=0.117). There were no statistically significant differences among patients with active Behçet uveitis, inactive Behçet uveitis and healthy controls with regard to serum nitrite levels.
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Abstract (Original Language): 
Çalışmamızda Behçet üveitli hastalarda serum nitrik oksid düzeyinin üveit aktivitesiyle olan ilişkisinin ortaya konulması amaçlanmıştır. Çalışmaya klinik muayene ve fundus flöresein anjiyografi ile aktif Behçet üveit tanısı konulan 25 hasta ile, son 12 aydır atak geçirmediği tespit edilen, inaktif 10 Behçet üveit hastası dahil edildi. Yaş ve cinsiyet açısından uyumlu, herhangi bir oküler ya da sistemik patolojisi bulunmayan 19 olgu, kontrol grubu olarak alındı. Serum nitrit düzeyleri Griess reaksiyonu ile tespit edildi. Nitrik oksid düzeyleri, serum Creaktif protein, α-1 antitripsin ve seruloplazmin düzeyleri ile karşılaştırıldı. Aktif Behçet üveit, inaktif Behçet üveit ve kontrol gruplarının serum nitrit düzeyleri arasındaki farklılık istatistiksel olarak anlamlı bulunmaz iken (p=0.883), C-reaktif protein ve α-1 antitripsin düzeyleri arasındaki farklılık istatistiksel olarak anlamlı bulunmuştur (sırasıyla p=0.003 ve p=0.01). Seruloplazmin düzeyleri arasındaki farklılık ise istatistiksel olarak anlamlı değildir (p=0.117). Aktif üveitli, inaktif üveitli hastalar ile kontrol gruplarının serum nitrit düzeyleri arasında istatistiksel olarak anlamlı bir farklılık tespit edilmemiştir.
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  • 3
137-141
  • Turkish

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