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Sağlıklı genç-erişkin erkeklerde trombosit fonksiyonlarının ve epinefrine cevapsızlığın incelenmesi

Evaluation of platelet function and lack of response to epinephrine in healthy young-adult men

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2006

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Abstract (2. Language): 
The rate of a decreased response to ADP and a lack of response to epinephrine by platelets on the optical aggregometer is reported to be between 16% to 40% in studies on various populations. We aimed to evaluate the platelet functions and to determine the rate of lack of response to epinephrine in healthy young-adult men. A total of 52 healthy volunteers aged between 19 to 42 were evaluated. The subjects were classified into three groups as nonresponder, semiresponder and normal according to their response to 100 µM epinephrine on the optical aggregometer. The nonresponder rate was 7.7%, and the semiresponder rate was 5.8%. A decreased response to epinephrine was associated with both decreased maximum aggregation of ADP and collagen, and did not affect the aggregation of arachidonic asid and thrombin, and ATP release. In conclusion, impaired response to epinephrine may be seen in one in every 3-6 persons, and this impaired response may also affect the other stimulating agents. These properties may be protective against thrombosis since there is no bleeding tendency and have similarity to aspirin usage.
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Abstract (Original Language): 
Trombositlerin agregometrede epinefrine karşı cevapsızlık göstermeleri ve ADP'ye karşı da azalmış yanıt vermeleri farklı topluluklarda yapılmış çalışmalarda %16-40 sıklığında bulunmuştur. Bu çalışmada sağlıklı genç-erişkin erkeklerde trombosit fonksiyonlarının incelenmesi ve epinefrine cevapsızlığın sıklığının araştırılması amaçlandı. Ondokuz-42 yaş arası, sağlıklı 52 erkek gönüllü değerlendirildi. Denekler optik agregometrede 100 µM epinefrine karşı gösterdikleri maksimum agregasyon cevaplarına göre cevapsız, yarı cevaplı ve normal olarak üç gruba ayrıldı. Yüzde 7.7 oranında cevapsız, %5.8 oranında yarı cevaplı bulundu. Epinefrine karşı agregasyon cevabının bozulmasının hem ADP hem de kollajene karşı agregasyonu azalttığı, araşidonik asid ve trombin agregasyonları ile ATP sekresyonunu etkilemediği gözlendi. Sonuçta her 3-6 kişiden birinde epinefrine cevabın bozuk olabileceği, bu bozukluğun diğer uyarıcı ajanları da etkileyebileceği, kanama yatkınlığının gözlenmemesi ve aspirin kullanımıyla benzeşmesinden yola çıkarak tromboza karşı doğal bir koruma olabileceği düşünüldü.
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  • 3
146-150
  • Turkish

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