Buradasınız

İskemik kalp hastalığı olan hastalarda glokomatöz risk faktörleri

Glaucomatous risk factors in patients with ischemic heart disease

Journal Name:

Publication Year:

Abstract (2. Language): 
It has been demonstrated that ischemia and systemic hypertension each are the risk factors for elevated intraocular pressure. In this study some of the risk factors important for glaucoma in patients with ischemic heart disease were evaluated. Otherwise healthy patients with age of >35 years and diagnosed to have ischemic heart disease by the Department of Cardiology were included in the study. Central corneal thickness measurements of the patients were made with Pacline Opticone Ultrasonic Pacimetry, and intraocular pressures were measured with Goldmann applanation tonometry. Retinal nerve fiber layer thickness measurements were made with NFA II (GDx VCC). A total of 90 eyes of 51 patients (39 male and 12 female) in the patient group and a total of 100 eyes of 50 cases (35 male and 15 female) in the control group were enrolled in the study. There were no significant differences between the control and study groups with respect to age and gender. Intraocular pressure was 16.58±2.92 mmHg in the patient group and 16.86±2.92 mmHg in the control group, and there was no statistically significant difference between the groups. Central corneal thickness was 538.97±36.23 in the patient group and 542.13±38.45 in the control group, and there was no significant difference between the groups. There were also no significant differences between the study and control groups with respect to parameters such as TSNIT, SA, IA and NFI in the measurement of retinal nerve fiber layer thickness. Intraocular pressure, central corneal thickness and retinal nerve fiber layer thickness measurements were not found as high enough to be risk factors for glaucoma in patients with ischemic heart disease.
Abstract (Original Language): 
İskemi ve sistemik hipertansiyonun yükselmiş göz içi basıncı için birer risk faktörü olduğu gösterilmiştir. Bu çalışmada iskemik kalp hastalığı olan olgularda glokom için önemli risk faktörlerinden bazıları araştırılmıştır. Kardiyoloji polikliniği tarafından iskemik kalp hastalığı tanısı konulan 35 yaş üzeri, başka herhangi bir dahili problemi olmayan hastalar çalışma kapsamına alınmıştır. Olguların santral kornea kalınlıkları Pacline Optikon Ultrasonik pakimetri cihazı, göz içi basınçları Goldman aplanasyon tonometresi ile ölçüldü. Retina sinir lifi kalınlığı ölçümü ise NFA II (GDx VCC) cihazı ile yapıldı. Hasta grubunda 39'u erkek, 12'si kadın toplam 51 hastanın 90 gözü, kontrol grubunda ise 35'i erkek, 15'i kadın toplam 50 olgunun 100 gözü çalışmaya alındı. İskemik kalp hastalığı grubu ile kontrol grubu arasında yaş ve cinsiyet yönünden istatistiksel olarak anlamlı bir farklılık yoktu. Göz içi basıncı iskemik kalp hastalığı grubunda 16.58±2.92 mmHg, kontrol grubunda 16.86±2.92 mmHg idi ve istatistiksel olarak anlamlı bir farklılık bulunmadı. Santral kornea kalınlığı iskemik kalp hastalığı grubunda 538.97±36.23, kontrol grubunda 542.13±38.45 idi ve aynı şekilde istatistiksel olarak anlamlı bir farklılık bulunmadı. Retina sinir lifi kalınlığı ölçümü açısından bakıldığında ise, TSNIT, SA, IA ve NFI gibi parametreler incelendiğinde aynı şekilde istatistiksel olarak anlamlı bir farklılık bulunmadı. İskemik kalp hastalığı olan kişilerde; göz içi basıncı, santral kornea kalınlığı ve retina sinir lifi kalınlığı ölçümleri kontrol grubu ile karşılaştırıldığında glokom için risk faktörü oluşturabilecek düzeyde tespit edilmemiştir.
96-100

REFERENCES

References: 

1. Leske MC. The epidemiology of
open-angle glaucoma: a review.
Am J Epidemiol 1983; 118: 166-
191.
2. Grunwald JE, Piltz J, Hariprasad
SM, Dupont J, Maguire MG.
Optic nerve blood flow in glaucoma: effect of systemic hypertension. Am J Ophthalmol 1999; 127:
516-522.
3. Waldmann E, Gasser P, Dubler B,
Huber C, Flammer J. Silent
myocardial ischemia in glaucoma
and cataract patients. Graefes
Arch Clin Exp Ophthalmol 1996;
234: 595-598.
4. Kaiser HJ, Flammer J, Burckhardt
D. Silent myocardial ischemia in
glaucoma patient. Ophthalmologica 1993; 207: 6-7.
5. Perasalo R, Perasalo J, Raitta C.
Electrocardiographic changes in
institutionalized geriatric glaucoma patients. Graefes Arch Clin
Exp Ophthalmol 1992; 230: 213-
217.
6. Martial GH, Riva CE, Dorner
GT, et al. Response of choroidal
blood flow in the foveal region to
hyperoxia and hyperoxia-hypercapnia. Curr Eye Res 2000; 21:
669-676.
7. Alm A, Bill A. The oxygen supply
to the retina. II. Effects of high
intraocular pressure and of increased arterial carbon dioxide
tension on uveal and retinal blood
flow in cats. Acta Physiol Scand
1972; 84: 306-319.100 · Haziran 2007 · Gülhane TD Ergin ve ark.
8. Alm A, Bill A. Ocular and optic
nevre blood flow at normal and
increased pressure in monkeys: a
study with radioactively labeled
microspheres including flow
determinations in the brain and
some other tissues. Exp Eye Res
1973; 15: 15-29.
9. Linsenmeier RA. The role of the
choroidal circulation in retinal
oxygenation. Exp Eye Res 1998;
67: S13.
10. Bill A, Spreber GO. Control of
retinal and choroidal blood flow.
Eye 1990; 4: 319-325.
11. Haefliger IO, Flammer J, Lüscher
TF, et al. Nitric oxide and
endothelin-1 are important regulators of human ophthalmic artery. Invest ophthalmol Vis Sci
1992; 33: 2340-2343.
12. Schmetterer L, Findl O, Strenn K,
et al. Effects of endothelin-1 on
ocular hemodynamics. Curr Eye
Res 1997; 16: 687-692.
13. Strenn K, Matulla B, Wolzt M, et
al. Reversal of endothelin-1
induced ocular hemodynamics
effects by low-dose nifedipine in
humans. Clin Pharmacol Ther
1998; 63: 54-63.
14. Polak K, Luksch A, Frank B, et al.
Regulation of human retinal
blood flow by endothelin-1. Exp
Eye Res 2003; 76: 633-640.
15. Rubanyi GM, Polokoff MA.
Endothelins: molecular biology,
biochemistry,pharmacology, physiology, and pathophysiology.
Pharmacol Rev 1994; 46: 325-415.
16. Schimitz-Spanke S, Schipke JD.
Potential role of endotheline-1
and endotheline antagonists in
cardiovascular disease. Basic Res
Cardiol 2000; 95: 290-298.
17. Deng D, Evans T, Mukherjee K,
et al. Diabetes induced vascular
dysfunction in the retina: role of
endothelins. Diabetologica 1999;
42: 1228-1234.
18. Schmetterer L, Woltz M. Ocular
blood flow and associated functional deviations in diabetic
retinopathy. Diabetologica 1999;
42: 387-405.
19. Iannaccone A, Letizia C, Pazzaglia
S, et al. Plasma endotheline-1
concentrations in patients with
retinal vein occlusions. Br J
Ophthalmol 1998; 82: 498-503.
20. Rolinski B, Geier SA, Sadri I, et al.
Endotheline-1 immunoreactivity
in plasma is elevated in HIV-1
infected patients with retinal
mikroangiopathic syndrome. Clin
Invest 1994; 72: 288-293.
21. Oku H, Sugiyama T, Kojima S, et
al. experimental optic cup
enlargement caused by endothelin-1 induced chronic optic nerve
head ischemia. Surv Ophthalmol
1999; 44: S34.
22. Cioffi GA, Sullivan P. The effect
of ischemia on the primate optic
nerve. Br J Ophthalmol 1999; 9:
S34-S36.
23. Celini M, Possati GL, Profazio V,
et al. Color Doppler imaging and
plasma levels of endothelin-1 in
low-tension glaucoma. Acta Ophthalmol Scand 1997; 234: 11-13.
24. Kaiser HJ, Flammer J, Wenk M,
et al. Endothelin-1 plasma levels
in normal tension glaucoma:
abnormal response to postural
changes. Graefes Arch Clin Exp
Ophthalmol 1995; 233: 484-488.
25. Taniguchi T, Okada K, Haque
MS, et al. Effects of endothelin-1
on intraocular pressure and aqueous humor dynamics in the rabbit
eye. Curr Eye Res 1994; 13: 461-
464.
26. Wiederholt M, Bielka S, Schweig
F, et al. Regulation of outflow rate
and resistance in the perfused anterior segment of the bovine eye.
Exp Eye Res 1995; 61: 233-234.
27. Laza GA, Bencardino G, Sestito
A. Association of endothelin-1
with transient myocardial ischemia in patients with unstable
angina pectoris. Am J Cardiol
2005; 95: 492-494.
28. Borries M, Heins M, Fischer Y, et
al. Endothelin and big endothelin
in coronary heart disease and
acute coronary syndromes. Z
Cardiol 1996; 85: 761-767.
29. Mitchell P, Wang JJ, Smith W.
Association of PEX with increased
vascular risk. Am J Ophthalmol
1997; 124: 648-687.
30. Citirik M, Sacaroðlu G, Batman
C, et al. A possible link between
the PEX and coronary arter disease. Eye 2007; 21: 11-15.
31. Schultz RO, Matsuda M, Yee R,
et al. Corneal endothelial changes
in type 1 and 2 diabetes mellitus.
Am J Ophthalmol 1984; 98: 401-
410.
32. Ozdek S, Lonneville YH, Önol
M, Yekin I, Hasanreisoðlu B.
Assessment of nerve fiber layer in
diabetic patients with scanning
laser polarimetry. Eye 2002; 16:
761-765.
33. Takahashi H, Goto T, Shoji T, et
al. Diabetes associated retinal
nerve fiber damage evaluated with
scanning laser polarimetry. Am J
Ophthalmol 2006; 142: 88-94.
34. Geeraerts T, Devys JM, Berges O,
et al. Sevoflurane effects on
retrobulbar arteries blood flow in
children. Br J Anaesth 2005; 94:
636-641.

Thank you for copying data from http://www.arastirmax.com