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Uzun süreli antiepileptik ilaç tedavisinin beyinsapı işitsel uyarılmış potansiyelleri üzerine olan etkisi ve klinik önemi

Effects of long-term antiepileptic drug therapy on brainstem auditory evoked potentials in epileptic patients and its clinical importance

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2008

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Abstract (2. Language): 
Results of the studies investigating the effects of antiepileptic drugs on auditory evoked potentials are contradictory. We, thus in this study, aimed to investigate the effects of long-term antiepileptic drug therapy on brainstem auditory evoked potentials in children with idiopathic epilepsia and to discuss its clinical importance. Fifty one children followed-up with the diagnosis of idiopathic epilepsia and receiving either valproic acid or carbamazepine for at least 6 months were enrolled in the study. The two study groups consisted of 35 patients using valproic acid (17 male and 18 female) and 16 patients using carbamazepine (7 male and 9 female). A control group including thirty three healthy children (17 male, 16 female) with a similar age and gender distribution was constituted. The age, gender, the dose and duration of treatment of the antiepileptic drug used and results of the auditory evoked potentials in all cases were recorded. Waves I, III and V, and interpeak latencies I-III and I-V of the study groups were significantly prolonged as compared with the control group (p<0.05). However, there were no significant differences among the groups with respect to wave I and interpeak latency III-V (p>0.05). In conclusion we demonstrated in this study that long-term antiepileptic drug therapy caused prolongation of auditory evoked potentials in epileptic patients. These results show that brainstem auditory evoked potentials are a sensitive and noninvasive test that may be used in demonstrating the adverse effects of long-term antiepileptic drug therapy on central nervous system.
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Abstract (Original Language): 
Antiepileptik ilaçların beyinsapı işitsel uyarılmış potansiyelleri üzerine olan etkileri ile ilgili çalışmaların sonuçları birbirleri ile çelişmektedir. Biz de bu çalışmada idiyopatik epilepsili çocuk hastalarda uzun süreli antiepileptik ilaç tedavisinin beyinsapı işitsel uyarılmış potansiyelleri üzerine olan etkilerini ve bu etkilerin klinik önemini tartışmayı amaçladık. Çalışmaya idiyopatik epilepsi tanısıyla takip edilmekte olup en az 6 aydır karbamazepin veya valproik asid kullanmakta olan 51 çocuk hasta kabul edildi. Çalışma grupları 35'i valproik asid (17 erkek, 18 kız) ve 16'sı karbamazepin (7 erkek, 9 kız) kullanmakta olan hastalardan oluşturuldu. Kontrol grubu benzer yaş ve cinsiyetteki 33 sağlıklı çocuktan (17 erkek, 16 kız) oluşturuldu. Hastaların yaş, cinsiyet, kullandıkları antiepileptik ilaç ve dozları, tedavi süreleri ve beyinsapı işitsel uyarılmış potansiyelleri sonuçları kaydedildi. Çalışma gruplarının dalga I, III, V ve IIII, I-V interpik latans değerleri kontrol grubuna göre anlamlı düzeyde uzamış olarak saptandı (p<0.05). Ancak dalga I ve III-V interpik latans değerleri bakımından gruplar arasında anlamlı bir farklılık saptanmadı (p>0.05). Sonuç olarak bu çalışmada epileptik hastalarda uzun süreli antiepileptik ilaç tedavisinin beyinsapı işitsel uyarılmış potansiyellerinde uzamaya neden olduğunu saptadık. Bu sonuçlar göstermiştir ki beyinsapı işitsel uyarılmış potansiyelleri uzun süreli antiepileptik tedavisinin santral sinir sistemi üzerine olan yan etkilerini göstermekte kullanılabilecek, duyarlı ve invaziv olmayan bir testtir.
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