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Kronik otoimmün tiroiditli çocuk ve ergenlerin klinik özellikleri

Clinical features of children and adolescents with chronic autoimmune thyroiditis

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Abstract (2. Language): 
Chronic autoimmune thyroiditis is the most common cause of thyroiditis among children and adolescents. This study was planned in order to determine the epidemiologic, clinical and laboratory characteristics of children and adolescents with chronic autoimmune thyroiditis. Ninety-seven subjects aged 5–18 years and who were followed up at our clinic from 2001 to 2007 were included in the study. Eighty-seven (89.75%) were girls and 10 (10.3%) were boys. Median age of the subjects was 12.40±2.97 years. It was seen that 86 (88.7%) subjects were diagnosed at puberty and 11 (11.3%) at childhood. Nearly half of the patients had hypothyroidism at the time of diagnosis and they were given L-thyroxine. When the subjects were tested for autoantibodies, 73.2% were anti-thyroglobulin antibody positive, 79.4% were anti-thyroperoxidase autoantibody positive. Our subjects were followed for a period of 3.41±1.24 years. At this period, the median L-thyroxine dose was 25 μgr/day (25-125 μgr/day). When the families of the subjects were tested, 20 mothers and five fathers had chronic autoimmune thyroiditis. Overall, the diagnosis of autoimmune thyroiditis can be more easily detected by detailed physical examination and laboratory studies.
Abstract (Original Language): 
Kronik otoimmün tiroidit, çocuk ve ergen yaş grubunda en sık görülen tiroidit nedenidir. Bu çalışma kliniğimizde takip edilmekte olan kronik otoimmün tiroiditli çocuk ve ergen hastaların epidemiyolojik, klinik ve laboratuvar özelliklerini belirlemek üzere planlandı. Çalışmaya 2001 ile 2007 yılları arasında kliniğimizde kronik otoimmün tiroidit nedeniyle takip edilen 5-18 yaş arası 97 olgu alındı. Olgularımızın %89.7’si kız (n=87) ve %10.3’ü erkek (n=10) olup, yaş ortalamaları 12.40±2.97 yıl olarak tespit edildi. Olguların %88.7’si ergenlik yaş grubunda (n=86) ve %11.3’ünün ise çocukluk yaş grubunda (n=11) tanı aldıkları gözlendi. Olgularımızın yaklaşık yarısının başvuru esnasında hipotiroidizmi olduğu ve L-tiroksin başlanıldığı öğrenildi. Otoantikorlar açısından incelediğimizde olgularımızın %73.2’sinde anti-T antikoru ve %79.4’ünde ise anti-TPO antikoru pozitif olarak saptandı. Hastalarımızın ortalama 3.41±1.24 yıllık izlemi esnasında ortanca L-tiroksin dozunun 25 μgr/gün (25-125 μgr/gün) olduğu tespit edildi. Kronik otoimmün tiroiditli hastalarımızın aileleri incelendiğinde 20 anne ve 5 babanın kronik otoimmün tiroiditli olduğu öğrenildi. Sonuç olarak; kronik otoimmün tiroiditin, detaylı fizik muayene ve laboratuvar incelemesi ile çocukluk yaş grubunda da tanı sıklığının artabileceği düşünüldü.

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