Buradasınız

Anasayfa » Content

Kronik otoimmün tiroiditli çocuk ve ergenlerin klinik özellikleri

Clinical features of children and adolescents with chronic autoimmune thyroiditis

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2008

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Chronic autoimmune thyroiditis is the most common cause of thyroiditis among children and adolescents. This study was planned in order to determine the epidemiologic, clinical and laboratory characteristics of children and adolescents with chronic autoimmune thyroiditis. Ninety-seven subjects aged 5–18 years and who were followed up at our clinic from 2001 to 2007 were included in the study. Eighty-seven (89.75%) were girls and 10 (10.3%) were boys. Median age of the subjects was 12.40±2.97 years. It was seen that 86 (88.7%) subjects were diagnosed at puberty and 11 (11.3%) at childhood. Nearly half of the patients had hypothyroidism at the time of diagnosis and they were given L-thyroxine. When the subjects were tested for autoantibodies, 73.2% were anti-thyroglobulin antibody positive, 79.4% were anti-thyroperoxidase autoantibody positive. Our subjects were followed for a period of 3.41±1.24 years. At this period, the median L-thyroxine dose was 25 μgr/day (25-125 μgr/day). When the families of the subjects were tested, 20 mothers and five fathers had chronic autoimmune thyroiditis. Overall, the diagnosis of autoimmune thyroiditis can be more easily detected by detailed physical examination and laboratory studies.
Abstract (Original Language): 
Kronik otoimmün tiroidit, çocuk ve ergen yaş grubunda en sık görülen tiroidit nedenidir. Bu çalışma kliniğimizde takip edilmekte olan kronik otoimmün tiroiditli çocuk ve ergen hastaların epidemiyolojik, klinik ve laboratuvar özelliklerini belirlemek üzere planlandı. Çalışmaya 2001 ile 2007 yılları arasında kliniğimizde kronik otoimmün tiroidit nedeniyle takip edilen 5-18 yaş arası 97 olgu alındı. Olgularımızın %89.7’si kız (n=87) ve %10.3’ü erkek (n=10) olup, yaş ortalamaları 12.40±2.97 yıl olarak tespit edildi. Olguların %88.7’si ergenlik yaş grubunda (n=86) ve %11.3’ünün ise çocukluk yaş grubunda (n=11) tanı aldıkları gözlendi. Olgularımızın yaklaşık yarısının başvuru esnasında hipotiroidizmi olduğu ve L-tiroksin başlanıldığı öğrenildi. Otoantikorlar açısından incelediğimizde olgularımızın %73.2’sinde anti-T antikoru ve %79.4’ünde ise anti-TPO antikoru pozitif olarak saptandı. Hastalarımızın ortalama 3.41±1.24 yıllık izlemi esnasında ortanca L-tiroksin dozunun 25 μgr/gün (25-125 μgr/gün) olduğu tespit edildi. Kronik otoimmün tiroiditli hastalarımızın aileleri incelendiğinde 20 anne ve 5 babanın kronik otoimmün tiroiditli olduğu öğrenildi. Sonuç olarak; kronik otoimmün tiroiditin, detaylı fizik muayene ve laboratuvar incelemesi ile çocukluk yaş grubunda da tanı sıklığının artabileceği düşünüldü.
FULL TEXT (PDF): 
PDF icon arastirmax-kronik-otoimmun-tiroiditli-cocuk-ergenlerin-klinik-ozellikleri.pdf

REFERENCES

References: 

1. Dayan CM, Daniels GH. Chronic autoimmune
thyroiditis. N Engl J Med 1996; 335: 99-107.
2. Rallison ML, Dobyns BM, Keating FR, Rall JE, Tyler FH.
Occurrence and natural history of chronic lymphocytic
thyroiditis in childhood. J Pediatr 1975; 86: 675-682.
3. Greenberg AH, Czernichow P, Hung W, Shelley W,
Winship T, Blizzard RM. Juvenile chronic lymphocytic
thyroiditis: clinical, laboratory and histological
correlations. J Clin Endocrinol Metab 1970; 30:
293-301.
4. Gönç EN, Yordam N. Çocukluk ve adölesanda tiroid
hastalıkları. In: Günöz H, Öcal G, Yordam N, Kurtoğlu
S (eds). Pediatrik Endokrinoloji. Ankara: Kalkan
Matbaacılık, 2003: 261-360.
5. Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N
Engl J Med 2003; 348: 2646-2655.
6. Kato I, Tajima K, Suchi T, et al. Chronic thyroiditis as a
risk factor of B-cell lymphoma in the thyroid gland. Jpn
J Cancer Res 1985; 76: 1085-1090.
7. Marwaha RK, Garg MK, Nijhavan VS, et al. Prevalence
of chronic lymphocytic thyroiditis in adolescent girls. J
Assoc Physicians India 1998; 46: 606-608.
8. Lipman TH, Rezvani I, DiGeorge AM. The natural
history of thyroid autoimmunity and thyroid function
in children with type 1 diabetes. J Pediatr 2007; 151:
10-12.
9. Zak T, Noczyńska A, Wasikowa R, Zaleska-Dorobisz
U, Golenko A. Chronic autoimmune thyroid disease
in children and adolescents in the years 1999-2004
in Lower Silesia, Poland. Hormones (Athens) 2005; 4:
45-48.
10. Demirbilek H, Kandemir N, Gonc EN, Ozon A,
Alikasifoglu A, Yordam N. Hashimoto’s thyroiditis
in children and adolescents: a retrospective study on
clinical, epidemiological and laboratory properties
of the disease. J Pediatr Endocrinol Metab 2007; 20:
1199-1205.
11. Lorini R, Gastaldi R, Traggiai C, Perucchin PP.
Hashimoto’s thyroiditis. Pediatr Endocrinol Rev 2003;
1: 205-211.
12. Segni M, Wood J, Pucarelli I, Toscano V, Toscano R,
Pasquino AM. Clustering of autoimmune thyroid
diseases in children and adolescents: a study of
66 families. J Pediatr Endocrinol Metab 2001; 14:
1271-1275.
13. LaFranchi S. Diagnosis and treatment of hypothyroidism
in children. Compr Ther 1987; 13: 20-30.
14. Radetti G, Gottardi E, Bona G, Corrias A, Salardi S,
Loche S; Study Group for Thyroid Diseases of the Italian
Society for Pediatric Endocrinology and Diabetes (SIEDP/
ISPED). The natural history of euthyroid Hashimoto’s
thyroiditis in children. J Pediatr 2006; 149: 827-832.
15. Wang SY, Tung YC, Tsai WY, Lee JS, Hsiao PH. Longterm outcome of hormonal status in Taiwanese children
with Hashimoto’s thyroiditis. Eur J Pediatr 2006; 165:
481-483.150 • Eylül 2008 • Gülhane Tıp Derg Yeşilkaya ve ark.
16. Caturegli P, Kimura H, Rocchi R, Rose NR. Autoimmune
thyroid diseases. Curr Opin Rheumatol 2007; 19:
44-48.
17. Friedlander J, Bauman E. Hashimoto's autoimmune
thyroiditis: eating for health applications for recovery.
h t t p : / / w w w . b a u m a n c o l l e g e . o r g / n e w s i t e / a r t i c l e s /
hashimotos-article.html (2007).
18. Lorini R, Gastaldi R, Traggiai C, Perucchin PP.
Hashimoto’s thyroiditis. Pediatr Endocrinol Rev 2003;
2: 205-211.
19. Yamauchi K, Ishihara A. Thyroid system-disrupting
chemicals: interference with thyroid hormone binding
to plasma proteins and the cellular thyroid hormone
signaling pathway. Rev Environ Health 2006; 21:
229-251.
20. Crofton KM, Craft ES, Hedge JM, et al. Thyroid-hormonedisrupting chemicals: evidence for dose-dependent
additivity or synergism. Environ Health Perspect 2005;
113: 1549-1554.

Thank you for copying data from http://www.arastirmax.com