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Laparoskopik kolesistektomi sonrası ağrı tedavisinde tramadolün devamlı infüzyon ve hasta kontrollü analjezi ile uygulanmasının karşılaştırılması

Comparison of tramadol use in continuous infusion versus patient controlled analgesia in pain management after laparoscopic cholecystectomy

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2009

Key Words:

Keywords (Original Language):

Author Name
Abstract (2. Language): 
Laparoscopic cholecystectomy is the gold standart operation in cholelithiasis. The efficacy, consumption and side effects of tramadol analgesia used either continuous infusion or patient controlled analgesia after laparoscopic cholecystectomy were compared in the present study. Thirty-five patients were recruited in each group constituted prospectively in a randomized manner. Tramadol with an intravenous loading dose of 100 mg and a subsequently continuous infusion of 12.5 mg/h for 24 hours was given in Group I. Patient controlled analgesia was used in Group II, and an intravenous loading dose of 50 mg tramadol with a basal infusion rate of 5 mg/h, a bolus dose of 20 mg, a lock-out time of 30 minute and a maximum dose of 200 mg with 4 hours limited were performed. Visual analog scale scores (0-100), peripheral oxygen saturation, respiratory rate, heart rate and noninvasive arterial blood pressure values were recorded in all patients at 0, 2, 4, 8, 12 and 24 hours. There were no significant differences between the two groups regarding age, gender, weight, ASA status and duration of the operation. There were no significant differences between the two groups on the basis of visual analog scale scores obtained at any of the time measurements. All the patients in Group I were treated with a total tramadol consumption of 400 mg whereas the patients in Group II were treated with a mean tramadol consumption of 164±52.19 (60-200) mg. Tramadol proved its efficacy and safety in the present study. There were no significant differences between the use of the drug in either route regarding efficacy.
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Abstract (Original Language): 
Kolelitiyazisin tedavisinde altın standart laparoskopik kolesistektomidir. Bu çalış- mada laparoskopik kolesistektomi sonrası devamlı infüzyon veya hasta kontrollü analjezi olarak uygulanan tramadol analjezilerinin etkinliği, tüketimi ve yan etkileri karşılaştırılmıştır. Prospektif ve randomize olarak oluşturulan her iki grupta 35’er hasta çalışmaya dahil edildi. Grup I’deki hastalarda tramadol 100 mg intravenöz olarak verildikten sonra 12.5 mg/saat hızda 24 saat devamlı infüze edildi. Grup II’deki hastalara hasta kontrollü analjezi kullanıldı ve 50 mg yükleme dozu, 5 mg/ saat bazal infüzyon, bolus doz 20 mg, kilitli kalma 30 dk, 4 saat limitli 200 mg tramadol uygulandı. Hastaların 0, 2, 4, 8, 12, 24. saatlerde vizuel analog skala skorları (0-100), periferik oksijen satürasyonu, solunum sayısı, kalp atım hızı, non-invaziv arteryal kan basıncı değerleri kaydedildi. İki grup arasında yaş, cinsiyet, kilo, ASA ve ameliyat süresi açısından anlamlı farklılıklar saptanmadı. Vizuel analog skala skoruna göre hiçbir çalışma saatinde farklılık saptanmadı. Grup I’deki hastaların hepsi 400 mg tramadol ile tedavi olurken, Grup II’deki hastalar ise 164±52.19 (60- 200) mg tramadol ile tedavi edildi. Laparoskopik kolesistektomi sonrasında ağrı tedavisinde tramadol etkin ve güvenilir bulundu. İlacın her iki yöntemle verilmesinde etkinlik açısından farklılık saptanmadı.
FULL TEXT (PDF): 
PDF icon arastirmax-laparoskopik-kolesistektomi-sonrasi-agri-tedavisinde-tramadolun-devamli-infuzyon-hasta-kontrollu-analjezi-ile-uygulanmasinin-karsilastirilmasi.pdf
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  • Turkish

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