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Akciğer kanserli hastalarda primer tümör tanısı ve evrelemede Tc-99m glutatyon sintigrafisinin rolü: ön sonuçlar

Tc-99m glutathione scintigraphy in the detection of primary tumor and staging of patients with lung cancer: a preliminary report

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2009

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Abstract (2. Language): 
The aim of this preliminary study was to investigate the potential role of Tc-99m GSH scintigraphy in the diagnosis and staging of patients with lung cancer. Twenty five patients with newly biopsy-proven primary lung cancer were included in this study. Whole body imaging was performed at the 1st and 3rd hours after the injection of 15 mCi (555 MBq) of Tc-99m GSH. Thorax SPECT imaging was also performed at the 1st hour in all patients. SPECT and whole body imaging showed increased tracer uptake in primary lesion sites in 23 and 22 of 25 patients with lung cancer, respectively. The tumor/background activity ratios in early and late images were 1.29 to 2.35 (mean 1.74) and 1.41 to 4.03 (mean 2.01), respectively. Mediastinum could not be clearly evaluated due to high blood pool activity of Tc-99m GSH. According to the results of this study, detection rate of distant metastases with Tc-99m GSH is not adequate. As a nonspecific tumor imaging agent, Tc-99m GSH scintigraphy has not enough specificity for using in a routine fashion in lung cancer. However, it could be a promising radiopharmaceutical due to having potential to visualize in vivo GSH metabolism which is important in chemo- or radio-therapy resistance.
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Abstract (Original Language): 
Bu öncü çalışmanın amacı akciğer kanserli hastalarda tanı ve evrelemede Tc-99m GSH sintigrafisinin potansiyel rolünün araştırılmasıdır. Bu çalışmaya yeni tanı konulmuş ve biyopsi ile tanısı doğrulanmış 25 akciğer kanserli hasta dahil edildi. On beş mCi (555 MBq) Tc-99m GSH enjeksiyonu sonrası 1. ve 3. saatte tüm vücut taraması ve 1. saatte toraks SPECT görüntülemesi yapılmıştır. SPECT ve tüm vücut taraması sırası ile 25 hastanın 23 ve 22’sinde primer tümöre ait artmış aktivite tutulumu saptanmıştır. Tümör/geri plan aktivitesi erken ve geç görüntülerde sırası ile 1.29-2.35 (ortalama 1.74) ve 1.41-4.03 (ortalama 2.01) olarak bulunmuştur. Tc-99m GSH’a ait yüksek kan havuzu aktivitesi nedeni ile mediyastinal lenf nodları net olarak değerlendirilememiştir. Çalışma sonuçlarımıza göre Tc-99m GSH sintigrafisinin uzak metastaz tespitindeki rolü yeterli duyarlılıkta bulunmamıştır. Tc-99m GSH sintigrafisi, non-spesifik bir tümör görüntüleme ajanı olarak akciğer kanserlerinde rutinde kullanım için yeterli özgüllüğe sahip değildir. Bununla birlikte, kemo- veya radyo-terapi direncinin değerlendirilmesinde öneme sahip olabilecek GSH metabolizmasını in vivo gösterebilme potansiyeli nedeniyle umut verici bir ajan olduğu düşünülmektedir.
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  • 4
235-238
  • English

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