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Hiperkalsemi nedeni ile başvuran bir çocukta nadir bir neden: akut lenfoblastik lösemi

An unusual diagnosis in a child presenting with hypercalcemia: acute lymphoblastic leukemia

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2010

Key Words:

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Abstract (2. Language): 
Hypercalcemia is a rare complication of acute lymphoblastic leukemia in childhood. We report a 4-year-old boy who presented with hypercalcemia and was diagnosed to have acute leukemia. The laboratory tests for main causes of hypercalcemia (Hyperparathyroidism, hypervitaminosis A and D, hyperthyroidism) were within normal limits. Hypercalcemia was treated with intravenous isotonic sodium chloride solution, furosemide and corticosteroids. In repeat laboratory tests performed on day 4 of admission, a normal complete blood cell count was found, but peripheral blood smear examination at this time revealed atypical lymphocytes. A bone marrow aspiration was performed, and 80% lymphoblasts were determined. The diagnosis of acute leukemia cannot be excluded in a patient with hypercalcemia and normal complete blood cell count and peripheral blood smear examination results. Repeat laboratory and detailed peripheral blood smear examinations are necessary to make a correct diagnosis in such cases.
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Abstract (Original Language): 
Hiperkalsemi çocukluk çağı akut lenfoblastik lösemilerinde nadir bir komplikasyondur. Bu yazıda hiperkalsemi ile başvuran ve akut lösemi tanısı konulan 4 yaşında bir erkek olgu sunulmuştur. Hiperkalseminin ana nedenlerine (hiperparatroidi, vitamin A veya D aşırı alımı, hipertiroidizm) yönelik laboratuvar testler normal bulundu. Hiperkalsemi, intravenöz izotonik sodyum klorür, furosemid ve steroidler ile tedavi edildi. İzleminin dördüncü gününde tekrarlanan laboratuvar testlerinde tam kan sayımı normal olarak bulundu, fakat periferik yayma incelemesinde atipik lenfositler tespit edildi. Yapılan kemik iliği aspirasyon incelemesinde %80 oranında lenfoblast belirlendi. Tam kan sayımı ve periferik yayma incelemesinin normal olduğu hiperkalsemili bir hastada akut lösemi tanısı ekarte edilemez. Böyle olgularda laboratuvar tetkiklerinin ve periferik yayma incelemelerinin tekrarlanması doğru tanı koyma açısından önemlidir.
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  • 1
47-48
  • English

REFERENCES

References: 

References
1. Mittal MK. Severe hypercalcemia as a harbinger of acute
lymphoblastic leukemia. Pediatr Emerg Care 2007; 23:
397-400.
2. McKay C, Furman WL. Hypercalcemia complicating
childhood malignancies. Cancer 1993; 72: 256–260.
3. Hibi S, Funaki H, Ichaiai-Kanai R, Todo S, Sawada T,
Imashuku S. Hypercalcemia in children presenting with
acute lymphoblastic leukemia. Int J Hematol 1997; 66:
353-357.
4. Turker M, Oren H, Yilmaz S, Cakmakci H, Demircioglu
F, Irken G. Unusual presentation of childhood acute
lymphoblastic leukemia: a case presenting with
hypercalcemia symptoms only. J Pediatr Hematol Oncol
2004; 26: 116-117.
5. Soni PN. Hypercalcemia and multiple osteolytic lesions
in childhood acute lymphoblastic leukemia. Postgrad
Med J 1993; 69: 483-485.
6. Ohoishi S, Koshibu T, Kazama H, Shinomiya N, Aoki T.
Common acute lymphoblastic leukemia preceded by
hypercalcemia in an infant. Acta Paediatr Jpn 1996; 38:
549-552.
7. Harguindey S, DeCastro L, Barcos M, Getaz EP,
Henderson ES, Freeman A. Hypercalcemia complicating
childhood malignancies: a report of seven cases with
some pathophysiological considerations. Cancer 1979;
44: 2280-2290.
8. Buonuomo PS, Ruggiero A, Piastra M, Riccardi R, Polidori
G, Chiaretti A. A case of acute lymphoblastic leukemia
presenting as severe hypercalcemia. Pediatr Hematol
Oncol 2004; 21: 475-479.
9. Ariyan CE, Sosa JA. Assessment and management of
patients with abnormal calcium. Crit Care Med 2004; 32:
146–154.
10. Andıran N, Alikasifoglu A, Kupeli S, Yetgin S. Use of
bisphosphonates for resistant hypercalcemia in children
with acute lymphoblastic leukemia: report of two cases
and review of the literature. Turk J Pediatr 2006; 48:
248-252.

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