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Rüptüre endometriyoma ve yüksek serum tümör belirteçleri: olgu sunumu

Ruptured endometrioma and high levels of tumor markers: a case report

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2010

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
CA 125 is a tumor-associated antigen. Its high levels are usually associated with ovarian malignancies, however increases in its levels may also be encountered in benign gynecologic conditions. Patients with endometriosis have rarely a serum CA 125 concentration exceeding 100 IU/ml. In this article a high level of CA 125 in a case of large ruptured ovarian endometrioma is reported. A 20-year-old nulligravida woman presented with an abdominal pain lasting for 8 hours. Transabdominal ultrasonography demonstrated bilaterally large endometriomas, and serum CA 125 and CA 19-9 levels were detected as 3434 U/ml and 1175 U/ml, respectively. Exploratory laparatomy was performed, and two endometrioma cysts with a diameter of 15 cm and 12 cm in the right and left overs, respectively, were excised. The diagnosis was confirmed histopathologically. The serum CA 125 and 19-9 levels tended to decrease in 8 weeks and declined to normal levels in 16 weeks. CA 125 and 19-9 are usually associated with a malignant process. However they may also increase in benign conditions such as a ruptured endometrioma. The case emphasizes that high levels of CA 125 and 19-9 may also be encountered in benign gynecologic conditions.
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Abstract (Original Language): 
CA 125 tümörlerle ilişkili bir antijendir. Genelde ovaryan malignitelerde yüksek seviyelerde tespit edilir, ancak benign jinekolojik patolojilerde de serumda artmış olarak bulunabilir. Endometriyozisli hastalarda serumdaki seviyesi nadiren 100 U/ml’yi geçer. Bu makalede rüptüre olmuş büyük endometriyomalı bir hastada yüksek seviyede tespit edilen CA 125 seviyesi rapor edilmiştir. Yirmi yaşında nulligravid bir hasta 8 saattir devam eden karın ağrısı şikayeti ile başvurdu. Transabdominal ultrasonografide bilateral büyük ovaryan endometriyoma saptandı ve serum CA 125 seviyesi 3434 U/ml ve CA 19-9 ise 1175 U/ml olarak tespit edildi. Eksploratris laparatomi yapılan hastada sağ ovaryan 15 cm, sol ovaryan 12 cm boyutunda endometriyoma kistleri eksize edildi. Histopatolojik olarak tanı doğrulandı. Sekiz hafta içerisinde serum CA 125 ve 19-9 seviyeleri azalarak, 16 hafta içerisinde normal seviyelere geriledi. CA 125 ve 19-9 genelde malign durumlarla ilişkilidir. Ancak rüptüre endometriyoma gibi benign durumlarda da yüksek seviyelerde tespit edilebilir. Bu olgu benign jinekolojik patolojilerde yüksek CA 125 ve 19-9 düzeyleri ile karşılaşabileceğimizi vurgulamaktadır.
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  • 1
49-51
  • Turkish

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