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Malign melanoma olgularının retrospektif değerlendirilmesi

Retrospective evaluation of malign melanoma patients

Journal Name:

  • Gülhane Tıp Dergisi

Publication Year:

  • 2011

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
The number of cases of malignant melanoma is increasing in parallel with the reports published worldwide. However, studies about malign melanoma in Turkey are limited. In this study retrospective evaluation of 46 malignant melanoma cases treated at our clinics between 2001 and 2009 is presented. The most common anatomic site of malign melanoma localization was lower extremities. In all the cases the diagnosis was established with excisional biopsy, and the most common observed histopathological type was nodular malign melanoma. The treatment protocol was planned considering the lesion depth, histopathological type and other risk factors. Only wide excision was performed on 4 patients with a tumor depth of <1 mm, sentinel lymph node biopsy and therapeutic lymph node dissection, when necessary were performed on patients with a tumor depth of 1-4 mm (n=12), and wide excision and elective lymph node dissection were performed on patients with a tumor depth of >4 mm (n=30). Distant metastasis was detected in 5 patients during the postoperative follow-up. The most frequent metastatic site was lung. Sentinel lymph node biopsy for malignant melanoma has gained an increasing popularity in recent years and its use has also increased at our clinics. However larger patient series and longer follow-up periods are necessary to reveal the effectiveness of sentinel lymph node biopsy.
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Abstract (Original Language): 
Malign melanoma olgu sayısı ve buna paralel olarak bu konu ile ilgili çalışmalar tüm dünyada hızla artış göstermektedir. Buna karşın ülkemizde malign melanoma ile ilgili çalışmalar sınırlı sayıdadır. Bu çalışmada, 2001 ile 2009 yılları arasında kliniğimizde tedavi edilen 46 malign melanoma olgusunun retrospektif değerlendirilmesi sunulmuştur. Malign melanomun en sık gözlendiği anatomik lokalizasyon alt ekstremite olarak tespit edildi. Tüm hastalarda, tanı eksizyonel biyopsi ile konuldu ve en çok karşılaşılan histopatolojik tip nodüler malign melanoma olarak saptandı. Tedavi lezyon kalınlığı, histopatolojik tip ve diğer risk faktörleri dikkate alınarak planlandı. Tümör kalınlığı 1 mm altındaki 4 hastaya sadece geniş eksizyon uygulanırken, 1-4 mm arasındakilere sentinel lenf nodu biyopsisi ve gerektiğinde terapötik lenf nodu diseksiyonu (n=12), 4 mm’den kalın lezyonlarda geniş eksizyon ve elektif lenf nodu diseksiyonu (n=30) uygulandı. Postoperatif takipler esnasında 5 hastada uzak metastaz saptandı. En sık metastaz görülen bölge akciğer olarak tespit edildi. Malign melanoma ile ilgili olarak sentinel lenf nodu biyopsisi son yıllarda önem kazanmış ve kliniğimizde de uygulanmasında artış olmuştur. Ancak sentinel lenf nodu biyopsisinin güvenilirliğini ortaya koyacak geniş hasta serilerine ve daha uzun hasta takip sürelerine ihtiyaç vardır
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  • 3
177-181
  • Turkish

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