An Evaluation & Correlation of C-Reactive Protein & Malondialdehyde in Acute Myocardial Infarction
Journal Name:
- Indian Journal of Basic & Applied Medical Research
Key Words:
Abstract (2. Language):
Introduction: Acute Myocardial Infarction (AMI) is a medical emergency despite impressive advancement in
diagnosis and management. The purpose of this study was to investigate and correlate C-reactive protein
(CRP), an inflammatory marker and serum Malondialdehyde (MDA), an index of lipid peroxidation in Acute
Myocardial Infarction.
Materials and Methods: The study was conducted in 80 subjects divided in two groups, 50 patients with AMI
(35 years to 81 years) and 30 age and sex matched healthy control. Serum CRP & Serum MDA readings were
taken on day 1, 3, 5 and at the time of discharge (8±1days) from the onset of symptoms which is found
statistically significant on all the days as compared to the control.
Results: CRP and MDA has a definite pattern in AMI, CRP level stars to decline by 3rd day and MDA levels
starts to decline by 5th day. There is also a significant positive correlation between CRP and MDA on day 1.
Conclusion: These results suggest that inflammation and oxidative stress may play important role in acute
myocardial infarction; hence, monitoring of these parameters is highly recommended which may be beneficial
to improve the patient’s outcome following AMI.
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