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Potential of Ficus Racemosa Bark: An immunomodulatory agent

Potential of Ficus Racemosa Bark: An immunomodulatory agent

Journal Name:

  • Indian Journal of Basic & Applied Medical Research

Publication Year:

  • 2012

Key Words:

Author Name
Abstract (2. Language): 
Introduction: Traditionally, Ficus racemosa , the plant is used for various health problems, diseases and to improve immunity. Hence, we planned to validate its use as immunomodulatory, scientifically. Materials & Methods: Petroleum ether, ethanol and aqueous extracts of bark of F. racemosa (50 and 100 mg/kg i.p.) was screened for immunomodulatory activity by delayed type hypersensitivity (DTH), neutrophil adhesion test and cyclophosphamide-induced neutropenia to assess the effect on immunity in Swiss albino mice. Preliminary phytochemical tests were done for active extract. Aqueous extract showed potentiation of DTH response in terms of significant increase in the mean difference in foot-pad thickness. Results: Aqueous extract significantly increased neutrophil adhesion to nylon fibers by 45.75%, and 44.57% at 50 and 100 mg/kg dose, respectively. Aqueous extract significantly opposed reduction in TLC and neutrophil induced by cyclophosphamide. Percentage reduction in TLC and neutrophil by aqueous extract was 33.85%, 32.23% and 15.60 %, 13.20 % at 50 and 100 mg/kg dose respectively. Petroleum ether and ethanolic extract was found to non-significant compared to aqueous extract in above tests. Conclusion: It is concluded that aqueous extract is a promising drug with immunostimulant properties. The extract was found to be most effective at low dose (50 mg/kg, i.p.), whereas, high dose (100 mg/kg, i.p.) of F. racemosa was moderately effective in modulating immune system, thus have great potential as a source for natural health products
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  • 2
120-127
  • English

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