Buradasınız

ROLE OF CYCLOOXYGENASE IN PROGNOSTIC COMPLICATIONS OF DIABETES MELLITUS SUBJECTS

ROLE OF CYCLOOXYGENASE IN PROGNOSTIC COMPLICATIONS OF DIABETES MELLITUS SUBJECTS

Journal Name:

Publication Year:

Abstract (2. Language): 
Background: Development of diabetes and its complications is associated with persistent inflammatory activity. It has been suggested that COX-mediated pathways may be involved in this inflammatory process in diabetes. For example, TXA2 and PGE2 released by platelets and monocytes due to the action of COX-1 and COX-2 respectively are important prostanoids involved in thrombosis and atherosclerosis development in diabetes. Materials: Blood sample was collected from 25 diabetic subjects and 25 age and sex matched controls. Regular routine Biochemical & Pathological parameters were analyzed in diabetes. Both COX-1 and COX-2 were analyzed in type II diabetes and diabetic animal models (Wistar rats). Results: Both COX-1 and COX-2 was increased in diabetic animal models (Wistar rats). The relationship between COX & Diabetes when studied in humans found that Type II diabetics showed slightly increased (but it is not significant) monocyte COX 2 & normal platelets COX1. Conclusion: This suggests that changes in COX levels in these inflammatory cells may be species-dependent.
259-267

REFERENCES

References: 

1. Yudkin JS, Stehouwer CD, Emeis JJ & Coppack SW. (1999) C-reactive protein in healthy subjects:
associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines
originating from adipose tissue? ArterioscleroThromb Vasc Biol. 19: 972-8.
2. Pasceri V, Chang J, Willerson JT & Yeh ET. (2001) Modulation of C-reactive protein-mediated monocyte
chemoattractant protein-I induction in human endothelial cells by anti-atherosclerosis drugs. Circulation.
103: 2531-4.
3. Zwaka TP, Hombach V & Torzewski J. (2001) C-reactive protein mediated low density lipoprotein uptake
by macrophages: implications for atherosclerosis. Circulation.103:1194-7.
4. DeWitt DL & Meade EA. (1993) Serum and glucocorticoid regulation of gene transcription and expression
of the prostaglandin H synthase-1 and prostaglandin H synthase-2 isozymes. Arch Biochem Biophys.
306(1):94-102
5. Garavito RM & DeWitt DL. (1999) The cyclooxygenase isoforms: structural insights into the conversion of
arachidonic acid to prostaglandins. Biochim Biophys Acta.1441(2-3):278-87
6. Khan AM, Lally KP, Larsen GL & Colasurdo GN. (2002) Enhanced release of thromboxane A(2) after
exposure of human airway epithelial cells to meconium. Pediatr Pulmonol. 33(2):111-6.
7. Raju J, Bajaj G, Chrusch J & Bird RP. (2006) Obese state leads to elevated levels of TGF-beta and COX
isoforms in platelets of Zucker rats. Mol Cell Biochem. Feb 14:1-6
8. Schafer A, Widder J, Eigenthaler M, Bischoff H, Ertl G & Bauersachs J. (2004) Increased platelet
activation in young Zucker rats with impaired glucose tolerance is improved by acarbose. Thromb
Haemost. 92(1):97-103
9. Liu J, Pestina TI, Berndt MC, Steward SA, Jackson CW & Gartner TK. (2004) The roles of ADP and TXA
in botrocetin/VWF-induced aggregation of washed platelets. J Thromb Haemost. 2(12):2213-22
10. Yu Y, Cheng Y, Fan J, Chen XS, Klein-Szanto A, Fitzgerald GA & Funk CD. (2005) Differential impact of
prostaglandin H synthase 1 knockdown on platelets and parturition. J Clin Invest. 115(4):986-95
11. Martin-Ventura JL, Blanco-Colio LM, Gomez-Hernandez A, Munoz-Garcia B, Vega M, Serrano J, Ortega
L, Hernandez G, Tunon J & Egido J. (2005) Intensive treatment with atorvastatin reduces inflammation in
mononuclear cells and human atherosclerotic lesions in one month. Stroke. 36(8):1796-800
12. Komers R, Zdychova J, Cahova M, Kazdova L, Lindsley JN & Anderson S. (2005) Renal cyclooxygenase-
2 in obese Zucker (fatty) rats. Kidney Int. 67(6):2151-8.
13. Kasiske BL, O'Donnell MP & Keane WF. (1992) The Zucker rat model of obesity, insulin resistance,
hyperlipidemia, and renal injury. Hypertension. 19(1 Suppl):I110-5
14. Eibl N, Krugluger W, Streit G, Schrattbauer K, Hopmeier P & Schernthaner G. (2004) Improved metabolic
control decreases platelet activation markers in patients with type-2 diabetes. Eur J Clin Invest. 34(3):205-9
15. Ferroni P, Basili S, Falco A & Davi G. (2004) Platelet activation in type 2 diabetes mellitus. J Thromb
Haemost. 2(8):1282-91
Indian Journal of Basic & Applied Medical Research; September 2012: Vol.-1, Issue-4, P. 259-267
266
www.ijbamr.com
16. Davi G, Chiarelli F, Santilli F, Pomilio M, Vigneri S, Falco A, Basili S, Ciabattoni G & Patrono C. (2003)
Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of
interleukin-6 and disease duration. Circulation. 107(25):3199-203
17. Belton OA, Duffy A, Toomey S & Fitzgerald DJ. (2003) Cyclooxygenase isoforms and platelet vessel wall
interactions in the apolipoprotein E knockout mouse model of atherosclerosis. Circulation. 108(24):3017-
23.
18. Di Minno G, Silver MJ, Cerbone AM, Rainone A, Postiglione A & Mancini M. (1986) Increased
fibrinogen binding to platelets from patients with familial hypercholesterolemia. Arteriosclerosis.
6:203.211
19. Lowe GDO, Wood DA, Douglas JT, Riemersma RA, Macintyre CC & Takase T. (1991) Relationships of
plasma viscosity, coagulation and fibrinolysis to coronary risk factors and angina. Thromb Haemost.
65:339.343
20. Hoffman CJ, Lawson WE, Miller RH & Hultin MB. (1994) Correlation of vitamin K.dependent clotting
factors with cholesterol and triglycerides in healthy young adults. Arterioscler Thromb. 14:1737.1740
21. Pitt B, Mancini GB, Ellis SG, Rosman HS, Park JS & McGovern ME. (1995) Pravastatin limitation of
atherosclerosis in the coronary arteries (PLAC I): reduction in atherosclerosis progression and clinical
events: PLAC I investigation. J Am Coll Cardiol. 26:1133-1139
22. Bluher M, Fasshauer M, Tonjes A, Kratzsch J, Schon MR & Paschke R. (2005) Association of interleukin-
6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity,
insulin sensitivity and glucose metabolism. Exp Clin Endocrinol Diabetes. 113(9):534-7
23. Shanmugam N, Gaw Gonzalo IT & Natarajan R. (2004) Molecular mechanisms of high glucose-induced
cyclooxygenase-2 expression in monocytes. Diabetes. 53(3):795-802
24. Cipollone F, Fazia ML, Iezzi A, Cuccurullo C, De Cesare D, Ucchino S, Spigonardo F, Marchetti A,
Buttitta F, Paloscia L, Mascellanti M, Cuccurullo F & Mezzetti A. (2005). Association between
prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in
human. Arterioscler Thromb Vasc Biol.25(9):1925-31
25. Lu Y & Wahl LM. (2005) Oxidative stress augments the production of matrix metalloproteinase-1,
cyclooxygenase-2, and prostaglandin E2 through enhancement of NF-kappa B activity in
lipopolysaccharide-activated human primary monocytes. J
Immunol. 175(8):5423-9
26. Cipollone F, Fazia ML, Iezzi A, Cuccurullo C, De Cesare D, Ucchino S, Spigonardo F, Marchetti A,
Buttitta F, Paloscia L, Mascellanti M, Cuccurullo F & Mezzetti A. (2005) Association between
prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in
human. Arterioscler Thromb Vasc Biol. 25(9):1925-31
27. King KM. (2003) A history of insulin: from discovery to modern alternatives. Br J Nurs. 12(19):1137-41.
28. N'guessan PD, Hippenstiel S, Etouem MO, Zahlten J, Beermann W, Lindner D, Opitz B, Witzenrath M,
Rosseau S, Suttorp N & Schmeck B. (2006) Streptococcus pneumoniae-induced p38 MAPK- and NFIndian
Journal of Basic & Applied Medical Research; September 2012: Vol.-1, Issue-4, P. 259-267
267
www.ijbamr.com
{kappa}B-dependent COX-2 expression in human lung epithelium. Am J Physiol Lung Cell Mol Physiol.
35(5)17-23.
29. Yokota T, Meka CS, Medina KL, Igarashi H, Comp PC, Takahashi M, Nishida M, Oritani K, Miyagawa J,
Funahashi T, Tomiyama Y, Matsuzawa Y & Kincade PW. (2002) Paracrine regulation of fat cell formation
in bone marrow cultures via adiponectin and prostaglandins. J Clin Invest. 109(10):1303-10
30. Gomez-Hernandez A, Sanchez-Galan E, Martin-Ventura JL, Vidal C, Blanco-Colio LM, Ortego M, Vega
M, Serrano J, Ortega L, Hernandez G, Tunon J & Egido J. (2006) Atorvastatin reduces the expression of
prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential
implications for plaque stabilization. J Cardiovasc Pharmacol. 47(1):60-9.

Thank you for copying data from http://www.arastirmax.com