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STUDY OF LIPID PROFILE IN PREECLAMPSIA

STUDY OF LIPID PROFILE IN PREECLAMPSIA

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Abstract (2. Language): 
Introduction: Pre-eclampsia is common medical complication of pregnancy. The association of altered lipid profile in essential hypertension is well documented. The present study was planned to study the role of altered lipid profile in the development of preeclampsia. Method: The study comprised of 30 normal pregnant women and 30 pre-eclamptic women in their third trimester of pregnancy. Serum Total cholesterol, Triglycerides, LDL Cholesterol and HDL- Cholesterol by enzymatic colorimetric method were done. Results: There was significant rise in Serum Total cholesterol, Triglycerides, LDL Cholesterol and a significant decrease in HDL Cholesterol in pre-eclamptic group as compared to normal healthy pregnant women. Conclusion : Altered lipid profile also has a potential role in the genesis of endothelial dysfunction and expression of pre-eclampsia. Early detection of these parameters may help patient by preventing complications in pre-eclampsia and is going to aid in better management of Pre-eclampsia.
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REFERENCES

References: 

1. Kamath S. Hypertension in pregnancy. JAPL 2006; 54: 269-270
2. Dutta D.C (2001), Hypertensive disorders in pregnancy, in :Textbook of obstetrics, Ed. Konar, H.L., 5th edition,234-55
3. Packer CS. Biochemical markers and physiological parameters as indices for identifying patients at risk of developing pre-eclampsia. J Hypertens 2005;23:(1)45-6.
4. Herrera, E (2002). Lipid metabolism in pregnancy and its consequences in the fetus and newborn. Endocrine 19 43 - 55.
5. Enquobahrie DA, Williams MA, Butler CL, Frederick IO, Miller RS, Luthy DA. Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia. Am J Hypertens 2004; 17(7): 574-581.
6. Gratacos E, Casals E, Gomez O, Llurba E, Mercador I, Cararach V, Cabero L. Increased susceptibility to low density lipoprotein oxidation in women with a history of preeclampsia. Br J of Obstet Gynaecol 2003; 110(4): 400-4
7. K. Yagi, Assay for lipid peroxide level and its clinical significance, in: Lipid Peroxides in Biology and Medicine, New York. 1982; 233¬242.
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Indian Journal of Basic & Applied Medical Research; December 2012: Issue-5, Vol.-2, P. 405-409
8. Khong TY, DE Wolf, Robetson WB, Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small for gestational age infants. Br J Obstet Gynaecol 1986;93:1049-1059.
9. Broughton Pipkin F. What is the place of genetics in the pathogenesis of pre-eclampsia? Biol Neonate
1999;76:325-330.
10. Chiang,A.N.,Yang, M.L.,Hung, J.H., Chon, P., Shyn, S.K. and Ng,H.T.(1995).Alteration of serum lipid levels and their biological relevances during and after pregnancy.Life sci. 56(26),2367-75.
11. Glueck, C.J.,Fallet, R.W. and Scheel, D.(1975) Effects of oestrogenic compounds on triglyceride kinetics.Metabolism 24, 537-45.
12. Kaaja R. Insulin resistance syndrome in pre-eclampsia. Sem Reprod Endocrinol 1998; 16: 41-6.
13. Kaaja R., Tikkanen MJ. (1995) Serum lipoproteins, insulin and urinary prostanoid metabolites in normal and hypertensive pregnant women.Obstet. Gynecol 1995;85(3):253-6.
14. Patrizia B, Giancarlo T, Franca E, et al. Lipoprotein metabolism during normal pregnancy. Am J Obstet Gynecol
1999; 181(2): 430-4.
15. Rubina A, Tabassum M. Pre-eclampsia and lipid profile. Pak J Med Sci 2007; 23: 751-4
16. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999; 340: 115-26.
17. Cekmen, M.B.,Erbagci, A.B.(2003) plasma lipid and lipoprotein concentration in pregnancy induced hypertention,Clin. Biochem.36(7),575-8.
18. Pirzado ZA, Sangi SA, Malik R. High density lipoprotein cholesterol (HDL) metabolism and its role in the
ischemic heart disease. Pak J Med Res 1999; 38: 38-41.
19. Wakatsuki A, Ikenoue N, Okatani Y, Shinohara K, Fukaya T. Lipoprotein particles in preeclamsia: Sucsceptibility to oxidative modification. Obstet Gynecol 2000; 96(1): 55-5
20. Lorensten, B. and Henriksen, T.(1998)Plasma lipids and vascular dysfunction in pre-eclampsia.

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