Buradasınız

Anasayfa » Content

A study of pulmonary tuberculosis in diabetes mellitus and its clinicoradiological correlation

Journal Name:

  • Indian Journal of Basic & Applied Medical Research

Publication Year:

  • 2015
Author Name
Abstract (2. Language): 
Introduction: India being Diabetic Capital with largest number of tuberculosis patients. Several studies have highlighted that Diabetes as a risk factor for TB. TB in Diabetic patients tend to have more cavitatory, less sputum positive with paucity in symptoms and signs. Hence We would like to highlight the varied pulmonary manifestations through our study. Methodology: Cross sectional study conducted in BH and CGH, Davangere with 50 patients. Pulmonary TB was diagnosed through history, examination, Sputum Microscopy and Chest X ray. Results and Discussion: Out of 50,36(72%) males & 14(28%). Maximum incidence of TB was seen in >50 years with peak incidence in 51-60 & 61-70.Mean age for males was 52.8 and females was 55.6 years. Symptoms noted were cough(92%), Fever(80%), Anorexia(58%), Loss of weight(56%), Dyspnea(42%), Hemoptysis(20%), Chest pain(20%),night sweats(20%). Duration of Diabetes were <1y(22%),2-5y(42%),6-10y(32%),>10y(4%). Mean FBS was 241 mg/dl and PPBS was 316 mg/dl. Sputum positive cases <50y(16/20) and >50y(21/30) with P=0.182. Cavitatory lesions were noted in 38% followed by non homogenous opacities in 22% of patients. Conclusions: There was a linear relationship between duration of DM & TB incidence. Majority of our patients had poorly controlled sugars, suggesting that severe hyperglycemia is associated with development of pulmonary TB. Sputum positivity was more in patients aged > 50 yrs. Cavitation and non homogeneous opacity were more common in patients aged > 50 yrs. Lower lung field TB was more common in aged >50 yrs and females. Early diagnosis and properly monitored treatment regimen is the only time proven answer.
Bookmark/Search this post with
FULL TEXT (PDF): 
PDF icon arastirmax-study-pulmonary-tuberculosis-diabetes-mellitus-and-its-clinicoradiological-correlation.pdf
  • 2
30
38
  • English

REFERENCES

References: 

1. Sarah Lou Bailey and Paul Grant. The tubercular diabetic : the impact of diabetes mellitus
on tuberculosis and its threat to global tuberculosis control. 2011;11(4) : 344-7.
2. Sarah Lou Bailey and Paul Grant. World Health Organization. Global tuberculosis control
: a short update to the 2009 report Geneva : WHO, 2009.
3. Crammer and Perachon; 1700
4. Lancet Infect Dis. Tuberculosis and diabetes mellitus: convergence of two epidemics.
2009 December;9(12);737-746.
5. Barach J. Historical facts in diabetes mellitus. Ann Med Hist 1928;10:387.
6. Root H. The association of diabetes and tuberculosis. N Engl J Med 1934;210:1, 78,127.
7. Banerjee S, Banerjee M. Diabetes and tuberculosis interface. J Indian Med Assoc
2005;103:318,320,322 passim.
8. Bashar M, Alcabes P, Rom WN, Condos R. Increased incidence of multidrug-resistant
tuberculosis in diabetic patients on the Bellevue Chest Service, 1987 to 1997. Chest
2001;120:1514–9.
9. Jeon CY,Murray MB. Diabetes mellitus increases the risk of active tuberculosis: a
systematic review of 13 observational studies. PLoS Med 2008;5:e152.
10. Stevenson CR, Forouhi NG, Roglic G et al. Diabetes and tuberculosis: the impact of the
diabetes epidemic on tuberculosis incidence. BMC Public Health 2007;7:234.
11. Mugusi F, Swai AB, Alberti KG, McLarty DG. Increased prevalence of diabetes mellitus
in patients with pulmonary tuberculosis in Tanzania. Tubercle 1990;71:271–6.
12. Restrepo BI, Fisher-Hoch SP, Crespo JG et al. Type 2 diabetes and tuberculosis in a
dynamic bi-national border population. Epidemiol Infect 2007;135:483–91.
13. LindosoAA,Waldman EA, Komatsu NK et al . Profile of tuberculosis patients progressing
to death, city of Sao Paulo, Brazil, 2002. Rev SaudePubl ica 2008;42:805–12.
14. Wang CS, Yang CJ, Chen HC et al. Impact of type 2 diabetes on manifestations and
treatment outcome of pulmonary tuberculosis. Epidemiol Infect 2009;137:203–10.
15. Dooley KE, Tang T, Golub JE, Dorman SE, Cronin W. Impact of diabetes mellitus on
treatment outcomes of patients with act ive tuberculosis. Am J Trop Med Hyg
2009;80:634–9.
16. Wallace O Fenn,HermannRahn.Hand book of Physiology.3rd edn;45-48.33
17. Harrison’s Principles of Internal Medicine,18th Edition,vol-2
18. Sentochnik DE, Eliopoulos GM. Infection and diabetes. In : Kahn CR, Weir GC, editors.
Joslin’s diabetes mellitus. 13th edition. Vol. 1. New Delhi: BI Waverly Pvt. Ltd;
1996.p.868-873, 881-882.
19. Hoddinott S, Dornan J, Bear JC, Farid NR. Immunoglobulin levels, immunodeficiency
and HLA in type 1 diabetes mellitus. Diabetologia1 982;23 :326-29.
20. Vishwanath R. History of tuberculosis. In :Rao KN, Vishwanath R, 78 Deshmukh MD,
editors. Textbook of tuberculosis. 2ndedit ion Vikas publishing house; 1981.p.2-3.
Indian Journal of Basic and Applied Medical Research; March 2015: Vol.-4, Issue- 2, P. 30 -38
38
www.ijbamr.com P ISSN: 2250-284X , E ISSN : 2250-2858
21. Feza B, Ozen KB, Gursel C, Abdullah S, Mahmut A. Pulmonary tuberculosis in patients
with diabetes mellitus. Respiration 2001 ;68:595-600.
22. Morris JT, Seaworth BJ, McAllister CK. Pulmonary tuberculosis in diabetics. Chest
1992;102:539-41.
23. King H, Aubert RE, Herman WH. Global burden of diabetes 1995-2005:Prevalence,
numerical estimates and projections. Diabetes care 1 998;2 1:14I4.
24. Mona B. Increased incidence of multidrug resistant tuberculosis in diabetic patients on
the Bellevue chest service; 1987-1997: clinical invest igat ions. Chest 2001;120:1514-19
25. Tripathy SR, Kar KP, Chakraborthy DC, Majumdar AK. Diabetes mellitus and pulmonary
tuberculosis - A prospective study. Ind J Tub 1 984;3 1:122.
26. Iseman MD. Tuberculosis down through the centuries.In :Iseman MD, editor. A clinician's
guide to tuberculosis.Philadelphia : Lippincott Wi lliams and Wilkins; 2000.p.9-10.
27. Khanna BK, Khare KS. Clubbing in pulmonary tuberculosis.Ind J Tub 1986;33:11.
28. Kishan J, Garg K, ;tuberculosis and diabetes , department of tuberculosis and chest
diseases, Govt medical college, Patiala.SAARC J TUBER.LUNG DIS .HIV/AIDS 2010
VII (2) 34-38.
29. Ezung T, Devi N T, Singh T.B. Pulmonary tuberculosis and diabetes mellitus a study;
Department of Medicine, Regional Institute of Medical Sciences, Imphal. J IndianMed
Assoc.2002 Jun;100(6):376,378-9.

Thank you for copying data from http://www.arastirmax.com