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Surveillance of Ceftaroline activity against clinical isolates of Methicillin Resistant Coagulase Negative Staphylococci (MRCoNS)

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Abstract (2. Language): 
Ceftaroline, a newer generation cephalosporin has a broad spectrum of activity against many bacterial pathogens including Methicillin resistant staphylococci. This activity is mainly attributed to its increased affinity towards altered penicillin binding proteins of Methicillin resistant isolates. In the present study a total of 50 Methicillin resistant Coagulase negative staphylococci (MRCoNS) were tested against ceftaroline by E strip methodology. All the isolates were inhibited at an MIC of ≤ 3μg/ml. The MIC 50 and the MIC 90 were 1 μg/ml and 2μg /ml respectively. To conclude, ceftaroline is a promising antibiotic for the treatment of Methicillin resistant Coagulase negative staphylococci
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