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Uzun etkili (kontrollü salınımlı) Salbutamol'ün klinik yararlılığı ve yan etkileri

Clinical capability and adverse effects of controlled release Salbutamol

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Abstract (2. Language): 
Twenty nine patients with asthma and chronic reversible obstructive pulmonary disease were studied. The l>atients ' ventolin inhaler tests' results were above 10 %. controlled release salbutamol tablets were given to the patients with 12-hour inten'als and no other bronchodilator agent had been added. Before and 4 and 8 weeks after the treatment the pulmonary function tests were applied. A fter 4 week improvements in f'l 'C and FE\T, were highly significant (p 0.001), and after 8 week improvements in Fl'C and FEVl, were also significant (p- 0.001). (Journal of Turgut Özal Medical Center 1(3):189-193,1994]
Abstract (Original Language): 
Araştırmamızda ventolin inhaler testi ile % 10'un üzerinde reversibilite gösteren kronik obstrukt if akciğer hastalığı (KOAIl) veya astım bronsiale tanısı almış 29 hasta tetkik edildi. Diğer bronkodilatör ilaçlar kullanılmadan, uzun etkili salbutamol (8 mg) sabah ve akşam 12 saat ara ile verildi. Tedavi öncesi ve tedaviden sonra 4 ve 8. haftalarda solunum fonksiyon testleri (SPT) ile kontrolleri yapıldı. 4. hafta sonunda l'l'C ve FEl'ı de ileri derecede düzelme ( p 0.001), 8. hafta sonunda ise Fl'C ve FEVjl de anlamlı (p 0.001) düzelme tesbit edildi. Tedaviden öncekine göre 4. ve 8. hajia EKC'lerinde kalp hızında anlamlı (p 0.05) azalma görüldü. {Turgut Özal Tıp Merkezi Dergisi 1 (3): 189-193.1994]
189-193

REFERENCES

References: 

1- Gross N. Chronic obstructive pulmonary disease. Chest 1990;97/ 2 (suppl): 19-23.
2- Palmer J. Is there a role for oral therapy in airways obstruction? Perspective on theories in Northern Europe. Meeting held at the Sedjewick Center. London 1987:6.
3- Popa V. Beta adrenergic drugs. Clinics in Chest Medicine 1986;7(3):3 13.
4- Ullman A, Hedner JB. Inhaled salmeterol improve astma symptoms without tachyplaxis. Clin Pharm 1990;28:33-5.
5- Clifford W, Zwillich J. Nocturmal astma therapy, (inhaled bitolterol versus sustained release theophylline). Am Rev RespirDis 1989;139:470-4.
6- Hall IP, Tattersfıeld AE. Beta agonists, Asthma. 3th ed. Chapman and Hall Medical London 1992.
7- Lipworth BJ, et al. Comparison of the efficacy and systemic effects of 4 mg and 8 mg formulations of salbutamol controlled release in patients with asthma. Eur J Clin Pharmacol 1990;39: 282-5.
8- Goodman GA. Catecholamines and sympathomimetic Drugs. The Paharmacological basis of therapeutics. 8th ed. MacMillan Press, New York 1990; 87-200.
9- Kayaalp O. fî adrenerjik reseptör blokerler. Tıbbi Farmakoloji, cilt 2, 2.baskı 1982:969-94.
10- Georgopoulos D, et al. Tolerance to 15 agonists in patients with COPD. Chest 1990; 97: 280-4.
11- Whelan CA, Johnson M. Salmeterol, but not salbutamol has anti-inflammatory action in guinea-pig skin. British Journal of Pharmacology 1991; 102 (proceedings suppl): 95.
12- Howarth PH, Djukanovic R, Walls A, Wilson et al. Future developments in anti-inflammatory studies. European Respiratory Review 1991; 1 (4): 276.
13- Johnson M, Vardey CJ, Whelan CJ. The therapeutic potential of long acting beta 2 adrenoceptor agonists in allergic inflammation. Clinical and experimental Allergy 1992; 22: 177.
Journal of Turgut Ö/al Medical Center 1(3): 1994
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Hasanoğlu (Arab) ve ark.
Uzun etkili (kontrollü sahnımlı) salbutamol 'ün klinik yararlılığı ve yan etkileri
14- Bernard J, Fredman M. Trial of a terbutalin aerosol in the treatment of asthma and a comparison of its effect with those of a salbutamol aerosol. Brith Jour Dis Ches 1990; 66: 222-6.
15- Piersan WE, et al. Long term, double blind comparison of controlled release albuterol versus
sustained release theophylline in adolescents and adults with asthma. Jour of All and Clin Immun 1990;85:618-26.
16- Morgan DJ. Clinic pharmacokinetics of fi-agongists. Clinical Pharmacokinetics 1990; 18 (4): 270-94.

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