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Yoğun Bakım Ünitelerinden Izole Edilen Stafilokok'ların Farklı Antibiyotiklere Direnç Oranları

The Resistance Rates of Different Antimicrobials in Staphylococci Isolated from Intensive Care Units

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2003

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Purpose: The aim of this study is to determine the resistance ratios of staphylococci to antimicrobial agents in intensive care units that might be useful from therapeutic and epidemiological points of view. Methods: Staphylococcus spp. were isolated from different specimens and identified according to conventional methods. Antimicrobial susceptibility test was performed by disk diffusion method according to proposals of NCCLS. Results: The incidence of resistance is higher among coagulase-negative staphylococcus (CNS) than Staphylococcus aureus. The antimicrobial resistance of 58 strains of CNS isolates was 29% teicoplanin, 51% ciprofloxacin, 58% gentamicin, 63% for each of co-trimoxazole and clindamycin, 79% erythromycin, 86% oxacillin and 96% penicillin The multiple antimicrobial resistances were revealed by 96% of CNS isolates. The multiple antimicrobial resistance was also observed in S. aureus isolates but less than CNS (78%). Of 32 S. aureus isolates, 12% co-trimoxazole, 25% teicoplanin, 46% erythromycin, 50% clindamycin, 68% gentamicin, 71% ciprofloxacin, 81% oxacillin and 100% penicillin were resistant. No resistance to vancomycin was observed. Conclusion: The findings revealed an increase in incidence of resistance and multiple antimicrobial resistant strains to commonly used antimicrobials in intensive care units. Therefore, prudent policy in prescribing and using of antibiotics is indispensable.
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Abstract (Original Language): 
Amaç: Çalışmamızın amacı antimikrobiyal ajanlara karşı stafilokokların direnç oranlarını incelemektir. Bu epidemiyolojik ve tedavi açısından faydalı olabilir. Yöntem: Farklı numunelerden izole edilen Stafilokok'lar geleneksel yöntemlerle tanımlandı. Antibiyotiklere duyarlılık testi NCCLS önerilerine göre disk diffüzyon yöntemi ile yapıldı. Sonuçlar: Koagulaz negatif stafilokok'larda antibiyotiklere (KNS) direnç oranı S. aureus'dan daha yüksek bulundu. Ellisekiz koagulaz negatif stafilokok suşunun %29'u teikoplanine, %51'i siprofloksasine, %58'i gentamisine, %63'ü ko-trimaksazol ve klindamisine, %79'u eritromisine, %96'sı penisiline, %86'sı oksasiline dirençli bulundu. Bu suşların %96'sı çoğul dirence sahipti, S. aureus^ da da çoğul direnç gözlendi, ancak CNS'den daha düşüktü (%78). Otuziki S. aureus suşunun, %12'si ko-trimaksazole, %25'i teikoplanine, %46'sı eritromisine, %50'si klindamisine, %68'i gentamisine, %71'i siprofloksasine, %81'i oksasiline ve tümü penisiline dirençli saptandı. Vankomisine direnç gözlenmedi. Tartışma: Antibiyotik kullanımının yaygın olduğu yoğun bakım ünitelerinde, dirençte ve çoğul dirençte artış vardır. Bu nedenle ihtiyatlı antibiyotik kullanım politikalarının uygulanması gereklidir.
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  • 4
173-175
  • Turkish

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