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Sürekli Ayaktan Periton Diyalizi (SAPD) Uygulanan Hastaların Nazal Örneklerinden İzole Edilen Stafilokoklarda Slime Oluşumu, Mupirosin ve Diğer Antibiyotiklere Duyarlılığın Araştırılması

Slime Production, Mupirocin and other Antibiotics Susceptibilities in Staphylococci Isolated from Nasal Samples in Patients Receiving Continuous Ambulatory Peritoneal Dialysis (CAPD)

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 2010

Key Words:

Keywords (Original Language):

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Abstract (2. Language): 
The aim of this study was to determine the prevalence of slime producingand to determine the mupirocin and other antibiotic susceptibilities of Staphylococcus aureus (S. aureus) and Coagulase negative staphylococci (CNS) strains isolated from nasal samples of patients on CAPD. This study was conducted at the Inonu University Medical Center, Microbiology Laboratory, Malatya, Turkey, between December 2007 and April 2008. Nasal swab cultures were taken from 72 CAPD patients to establish the prevalence of nasal staphylococci carriage. Fifty-one (70.8%) nasal culture were positive for staphylococci species. Between them 45 (76.2%) strains were identified as CNS and 14 (23.7%) strains were identified as S. aureus . Nineteen cultures were slime positive. The methicillin resistance rate for CNS strains was detected as 93% and S. aureus strains was detected as 50%. Five of the staphylococci strains were resistant to mupirocin. Resistance to multiple antibiotics was detected in both the slime producing and methicillin resistant staphylococci. Detection of staphylococci nasal carriage in CAPD patients and to get all precautions may be useful to prevent the infections with these microorganisms.
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Abstract (Original Language): 
Bu çalışmanın amacı; sürekli periton diyalizi tedavisi alan hastaların nazal kültürlerinden izole edilen Staphylococcus aureus (S. aureus) ve koagulaz negatif stafilokoklarda (KNS) slime oluşumunu ve mupirosin ile diğer antibiyotiklere duyarlılıklarını araştırmaktır. Çalışma; Aralık 2007-Nisan 2008 tarihleri arasında, Malatya’da İnönü Üniversitesi Tıp Merkezi, Mikrobiyoloji Laboratuvarında yapıldı. Nazal stafilokok taşıyıcılığını belirlemek için, SAPD uygulayan 72 hastadan nazal kültürler alındı. Nazal kültür yapılan hastaların 51(%70.8)’inde stafilokok türleri üredi. Stafilokok üreyen 51 örneğin 45 (%76.2)‘i KNS, 14 (%23.7)’ü S. aureus olarak tanımlandı. Metisilin direnci KNS için %93, S. aureus için %50 olarak saptandı. Ondokuz örnekte slime pozitif bulundu. Beş izolat mupirosin’e dirençli bulundu. Hem slime pozitif hem de metisiline dirençli olan örneklerde antibiyotiklere çoklu direnç bulunduğu saptandı. Sürekli periton diyalizi yapılan hastalarda nazal stafilokok taşıyıcılığının belirlenmesi ve gerekli önlemlerin alınması, bu mikroorganizma enfeksiyonlarının önlenmesinde faydalı olacaktır.
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  • 1
33-36
  • Turkish

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