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Romatoid Artrit'te Serum Immunoglobulin Düzeyleri: IgA Aktivite Kriteri mi?

Serum immunoglobulin levels in rheumatoid arthritis: Is I«A level an activity criterion?

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1996

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
As a consequence of impaired immune regulatory mechanisms there is a hyperactivity of B lymphocytes and excessive immunoglobulin production in rheumatoid arthritis (RA). Elevated levels of IgG and IgA are shown in several studies. In this study, we measured the immunoglobulin levels of the patients with RA in both activation and remission periods, and tried to determine if the IgA levels can be used as an activity criterion. We also tried to determine the rate of the selective IgA deficiency in a large population of RA patients and correlation of these findings with other laboratory and clinical parameters. The findings from these patients with RA suggest that: 1) Polyclonal hypergamaglobulinemia, which is seen in activation periods, is not seen in remission periods. 2) Elevation IgA levels seems to be a strong and elevation of IgG is a weak indicator for activity of RA. Also, the selective IgA deficiency, that is seen in 0.025% to 0.03% of the normal population , was not present our RA patient group.
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Abstract (Original Language): 
Romatoid Artrit'te (RA), immün regülatuar mekanizmalarda bozukluk sonucu B lenfositlerde hiperaktivasyon ve aşın miktarda immunoglobulin (Ig) yapımı vardır. Özellikle IgG ve IgA serum düzeylerinde artış birçok çalışmada gösterilmiştir. Bu çalışmada biz, RA'lı hastalarda hem aktif hem de remisyon dönemlerinde immunoglobulin düzeylerini ölçerek, özellikle serum IgA konsantrasyonunun aktivite kriteri olup olamayacağını, ek olarak geniş bir RA serisinde selektif IgA yetmezliğinin oranını ve bunların diğer laboratuar ve klinik parametreleriyle korelasyonunu araştırdık. RA'lı hasta gruplarından elde ettiğimiz sonuçlarla RA'da; 1) Aktivasyon döneminde görülen poliklonal hipergamaglobulıneminin remisyon döneminde görülmediğini, 2) IgA artışının RA için güçlü, IgG artışının ise daha zayıf bir aktivite kriteri olarak kabul edilebileceğini tespit ettik. Ayrıca normal populasyonda %0.25 ile %0.03 oranında bildirilen selektif IgA eksikliği bizim RA'lı hasta grubumuzda hiçbir hastada mevcut değildi.
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REFERENCES

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