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Parazit ile enfekte çocuklarda serum total IgE konsantrasyonları ve antiparazitik tedavinin IgE seviyelerine etkisi

Concentrations of Total Serum IgE in Parasitized Children and the Effects of the Antiparasitic Therapy on IgE Levels

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1996

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
Concentrations of total serum IgE in 90 parasitized children and 24 healthy control children between 7 and 11 years old were measured using enzyme immunoassay. Of 90 children, 46 were infected with Giardia lamblia, 26 with Enterobius vermicularis, and 18 with both of these parasites. The overall mean value of IgE in parasitized children was 170.17 ± 27.76 IU/ml, almost 24 of children had an IgE value of more than 100 IU/ml, and 5 showed a value of more than 1000 IU/ml. The mean value of IgE in control children was 39.41 ±14.68 IU/ml. IgE levels showed a significant difference between those two groups (p< 0.01). Children infected with G.lamblia were treated with metronidazole (15-20 mg/kg/day for 10 days), while those with E.vermicularis were treated with single dose mebendazole (100 mg/day), and in children having mixed G.lamblia and E.vermicularis infection, combination of metronidazole with mebendazole was used in therapy. After 15 days of the onset therapy, 73 children were reexamined for parasites and IgE levels. No parasite was found in this group. The mean value of IgE was found to be 145.12±28.19 and 76.56 ±19.63 IU/ml before and after therapy, respectively. There was significant difference in IgE concentrations between before and after therapy (p< 0.001). [Journal of Turgut Özal Medical Center 1996;3(4):332-335]
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Abstract (Original Language): 
90 parazitlenmiş çocuk ve 7 ila 11 yaşındaki 24 sağlıklı kontrol çocuklarda serum total IgE konsantrasyonlar enzim immunoassay ile ölçüldü. 90 çocuktan 46 de her iki parazit ile Giardia lamblia, Enterobius vermicularis 26, ve 18 ile enfekte edildi. Parazitlenmiş çocuklarda IgE genel ortalama değeri 170,17 ± 27,76 idi IU / ml, yaklaşık 24 çocuk fazla 100 IU / ml bir IgE değeri vardı ve 5 den fazla 1000 IU / ml değeri gösterdi. Kontrolü çocuklarda IgE ortalama değeri 39.41 ± 14.68 IU / ml idi. IgE düzeyleri bu iki grup (p <0.01) arasında anlamlı bir farklılık gösterdi. E.vermicularis olan tek bir doz mebendazol (100 mg / gün), ve G. karma çocuk sahibi olma tedavi edilen süre G.lamblia ile enfekte olan çocuklar, metronidazol (15-20 mg / gün boyunca 10 kg / gün) ile muamele edildi lamblia ve enfekte olanlara mebendazol metronidazol kombinasyon tedavisinde kullanılmıştır.Tedavi verildikten 15 gün sonra, 73 çocukta parazit ve serum IgE seviyeleri yönünden edildi. Parazit bu grupta bulunamadı. IgE ortalama değeri ± 145.12 28.19 ve 76.56 ± tedavi öncesi ve sonrası 19.63 IU / ml olarak tespit edildi. Tedavisi (p <0.001) öncesi ve sonrası arasındaki IgE konsantrasyonlarını anlamlı bir fark yoktu. [Turgut Özal Tıp Merkezi 1996 Dergisi, 3 (4) :332-335]
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  • 4
332-335
  • Turkish

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