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Hirschprung'lu hastaların kalın barsaklarında artmış nöroendokrin hücreler

Increased Populations of Neuroendocrine Cells in the Colon of Patients with Hirschprung's Disease

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1997

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The distribution of mucosal neuroendocrine (NE) cells in the colon from 21 patients with Hirschprung's disease (HD) and from 4 controls were studied. Immunohistochemical stains were done out using antibodies against chromogranin A and neuron-specific enolase (NSE). Immunostaining with both antibodies gave similar results: immunoreactive cells significantly increased in the aganglionic bowel compared with ganglionic bowel and controls (p<0.05). The increase in NE cells was found over the entire length of the aganglionic segments. These results demonstrating the increased levels of NE cells in the mucosa of aganglionic colon suggest that the NE cells may have a role in regulating the sustained contraction of the aganglionic intestine. [Journal of Turgut Özal Medical Center 1997;4(3):270-273]
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Abstract (Original Language): 
Hirschprımglu 21 hastanın kolon materyallerinde ve 4 kontrol biyopsisinde mukozal nöroendokrin hücrelerin dağılımı Chromogranin A ve NSE'ye karşı antikorlar kullanılarak immunohistokimyasal olarak incelendi. Her iki antikorla boyamada benzer sonuçlar elde edildi ve aganglionik bölgelerde immunoreaktif hücrelerde artış bulunduğu (p<0.05) görüldü.. Nöroendokrin hücrelerdeki bu artışın tüm aganglionik kolon segmentinde bulunduğu görülmüştür. Aganglionik bölgelerde bu hücrelerdeki artış, nöroendokrin hücrelerin sürekli kontraksiyonla ilişkili olabileceklerini düşündürmektedir. [Turgut Özal Tıp Merkezi Dergisi 1997;4(3):270-273]
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  • 3
270-273
  • Turkish

REFERENCES

References: 

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