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Malatya İlindeki Guatrlı Hastalarda Serum ve İdrar İyot Düzeyleri İle Tiroid Hormonlarının İlişkisi

The relationship between serum and urinary iodine levels and thyroid hormones in patients with goitre living in Malatya region

Journal Name:

  • İnönü Üniversitesi Tıp Fakültesi Dergisi

Publication Year:

  • 1998

Key Words:

Keywords (Original Language):

Author NameUniversity of AuthorFaculty of Author
Abstract (2. Language): 
The main cause of endemic goitre is iodine deficiency. The severity of iodine deficiency in any region can be evaluated from goitre prevalance, the iodine excretion in the urine, and the iodine content of drinking water. Thyroid function was evaluated in 41 patients with goitre, and compared with 15 healthy subjects (G0). The relationships between thyroid size, serum and urine iodine levels, and thyroid hormones were investigated. Patients were divided into three subgroups according to WHO's modified criteria. Serum iodine levels, 24-hour urinary iodine excretion (mg/24h), and iodine/creatinine (mgI/g) ratios of single urine samples correlated inversely with goitre size (G0; 6.37±2.35mg/dl, G1b; 5.35±1.55mg/dl, G2; 4.39±1.77mg/dl, G3; 4.13±1.87mg/dl, G0; 59.6±18.2 mg/24h, G1b; 48.5±22.7 mg/24h, G2; 30.8±12.3 mg/24h, G3; 39.4±21.4 mg/24h, G0; 83.54±38.6 mg/g, G1b; 60.82±8.91 mg/g, G2; 51.04±15.18 mg/g, G3; 44.82±21.47 mg/g, p<0.05, respectively). Serum thyroglobulin levels and the ratio of T3/T4 x100 were elevated with goitre size (p<0.05). Consequently, our patients, even our healthy subjects had low urinary excretion of iodine (<100 mg iodine/g creatinine). Evidently, Malatya is a moderately iodine deficient area of Turkey. For this reason, iodine prophylaxis programmes are urgently required. [Journal of Turgut Özal Medical Center 1998;5(1):18-23]
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Abstract (Original Language): 
Endemik guatrın esas nedeni iyot eksikliğidir. İyot eksikliğini belirlemek için guatr prevalansı, idrarla atılan iyot ve içme sularındaki iyot miktarının ölçülmesi esas alınmaktadır. Bu çalışmada, polikliniğimize başvuran ve yaşları 4.5-24 yıl arasında değişen 41 guatrlı hasta ile 15 sağlıklı kontrol grubunda (G0) guatr dereceleri ile serum ve idrardaki iyot düzeyleri ve tiroid hormonları arasındaki ilişkileri araştırmayı amaçladık Hastalar DSÖ'nün modify e kriterlerine göre, "tiroid bezi büyüklükleri dikkate alınarak, küçükten büyüğe doğru G1b (17 hasta), G2 (20 hasta) ve G3 (4 hasta) olmak üzere üç gruba ayrıldı. Serum iyotu (G0; 6.37±2.35 mg/dl, G1b; 5.35±1.55 mg/dl, G2; 4.39±1.77 mg/dl, G3; 4.13±1.87 mg/dl, p<0.05), 24 saatlik idrar iyotu (G0; 59.6±18.2 mg/gün, G1b; 48.5±22.7 mg/gün, G2; 30.8±12.3 mg/gün, G3; 39.4±21.4 mg/gün, p<0.05) ve spot idrar iyotu/ kreatinin (mg/g) oranı (G0; 83.54±38.6 mg/g, G^; 60.82±8.91 mg/g, G2; 51.04±15.18 mg/g, G3; 44.82±21.47 mg/g, p<0.05) guatr derecesi ile orantılı olarak azalma gösteriyordu. Serum tiroglobulin ile T3/T4xl00 oranı ise guatr derecesi artışına paralel olarak artma gösterdi (p<0.05). Sonuç olarak vakalarımızda hafif ve orta derecede iyot eksikliği olup, kontrol grubumuzda bile endemik guatr için önceden bildirilmiş olan sınırların olduğunu göstermektedir. Bu nedenle iyot profılaksisi için eğitici programlar başlatılmalı, iyotlu tuz ve gereğinde iyot tabletlerinin, hatta parenteral iyodun etkin bir şekilde kullanımı sağlanmalıdır. [Turgut Özal Tıp Merkezi Dergisi 1998;5(1):18-23]
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