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AKUT MİYOKARD İNFARKTÜSÜNDE L-KARNİTİN TEDAVİSİNİN VENTRİKÜLER GEÇ POTANSİYELLER ÜZERİNE ETKİSİ

The effects of L-carnitine administriation on ventricular late potentials in patients with acute myocardial infarction

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Abstract (2. Language): 
In this study we aimed to investigate the effects of L-carnitine administriation on ventricular late potentials in patients with acute myocardial infarction. A total of 54 patients with the diagnosis ofacut myocardial infarction were included in the study. Patients were randomly divided into two groups, L-carnitine group 27 patients (17 male, 10 female, mean age: 60+11 years), placebo group 27 patients (15 male, 12 female, mean age: 58 ±12 years). Signal averaged electrocardiogram (SOECG) recording was obtained in the first 48 hours of myocardial infarction. Measurments were repeated at the end of thrid week. L-carnitine (4gr/ day) and placebo were given to the patients randomly. Also, asetil salisilic acide, heparine infusion and if not contraindicated thrombolytic agents were given to all patients. There were no differences between two groups in the first recordings. In the second recordings while QRS duration and LAS 40 were decreased in L-carnitine group (p<0.05), it was not changed in placebo group (p>0.05). Late potential positivity was detected in 13 patients in L-carnitine group and 14 patients in placebo group in the first recordings (p>0.05). However, in the second recordings we found late potential positivity in 8 patients in L-carnitine group (p<0.05) and 12 patients in placebo group (p>0.05). It is concluded that the use of L-carnitine after acute myocardial infarction has a good effect on SOECG parameters without changing hemodynamic parameters.
Abstract (Original Language): 
Bu çalışmada akut miyokard infarktüslü olgularda L-kamitinin kullanımının, ventriküler geç potansiyeller üzerine olan etkisi araştırıldı. Çalışmaya akut miyokard infarktüsü tanısı ile kabul edilen 54 hasta alındı. Hastalar randomize olarak L-karnitin grubu 27 hasta (17 erkek, 10 kadın, yaş ort: 60±11 yıl) ve plasebo grubu 27 hasta (15 erkek, 12 kadın, yaş ort: 58±12 yıl) olarak iki gruba ayrıldı. Miyokard infarktüsünün ilk 48 saat içerisinde sinyal ortalama// elektrokardiyogrfı (SOEKG) kayıtları alındı. Ölçümler 3. hafta sonunda tekrar edildi. Hastalara randomize olarak, L-karnitin (n=27) 4x1 tb (4 gr/gün) ve plasebo verildi. Ayrıca hastaların tamamına asetil salisilik asit, heparin infüzyonu ve kontrendikasyonu olmayan vakalara trombolitik tedavi uygulandı. Birinci kayıtlarda iki grup arasında fark izlenmedi. İkinci kayıtlarda, L-karnitin grubunda QRS süresi ve LAS 40 değerlerinde düşüş izlenirken (p<0.05), plasebo grubunda ise anlamlı değişiklik olmadı (p>0.05). Geç potansiyel pozitifliği L-karnitin grubunda birinci kayıtta 13 hastada pozitif bulunurken, plasebo grubunda ise 14 hastada pozitif bulundu (p>0.05). İkinci kayıtlarda L-karnitin grubunda 8 hastada (p<0.05), plasebo grubunda 12 hastada pozitif olarak bulundu (p>0.05). Akut miyokard infaktüsünde L-karnitin kullanımının, hemodinamik veriler üzerine olumsuz bir etkisi olmadan, SOEKG parametreleri üzerine olumlu etkileri olduğu sonucuna varılmıştır.

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